Adrenergic Drugs Flashcards by Mina Sourial

Q

epinephrine works on which receptors?

A

a1, a2, B1, B2

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Q

norepinephrine works on which receptors?

A

a1, a2, B1

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Q

ephedrine works on which receptors?

A

a1, a2, B1, B2

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Q

dopamine works on which receptors?

low dose
intermediate dose
high dose

A

D1 = D2
D1 = D2 + B1
D1 = D2 + B1 + a1

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Q

tyramine (found in wine and cheese)

A

mixed

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Q

ADE of tyramine

A

5-HT syndrome if on MAOI

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Q

ADE of norepinephrine

A

reflex bradycardia

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Q

isoproterenol works on which receptors?

A

B1, B2 ONLY

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Q

dobutamine works on which receptors?

A

B1 ONLY

increases contractions WITHOUT increasing HR

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Q

albuterol/salmeterol work on which receptors?

A

B2

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Q

terbutaline works on which receptors?

A

B2

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Q

ritodrine works on which receptors?

A

B2

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Q

ADE of albuterol/salmeterol

A

palpitations, tachycardia, hyperglycemia

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Q

clonidine works on which receptors?

A

a2 AGONIST

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Q

clonidine MOA

A

decreases presynaptic Ca++ levels in a2 R’s of brainstem, inhibiting NE release

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Q

apraclonidine works on which receptors?

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A

a2 AGONIST

Q

a-methyldopa works on which receptors?

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A

a2 AGONIST

Q

ADE of clonidine

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A

sexual dysfunction

Q

ADE of a-methyldopa

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A

hemolytic anemia (+ Coombs test)

Q

phenylephrine works on which receptors?

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A

a1 AGONIST

Q

ADE of phenylephrine

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A

rebound congestion, HTN

Q

cocaine works on which receptors?

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A

a1, a2

Q

what is a unique characteristic of cocaine?

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A

it is the ONLY inherent vasoCONSTRICTOR

Q

MOA of amphetamines

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A

stimulates monoamines (NE, dopamine, and 5-HT)

- blocks catecholamine reuptake