epinephrine works on which receptors?
a1, a2, B1, B2
norepinephrine works on which receptors?
a1, a2, B1
ephedrine works on which receptors?
a1, a2, B1, B2
dopamine works on which receptors?
- low dose
- intermediate dose
- high dose
- D1 = D2
- D1 = D2 + B1
- D1 = D2 + B1 + a1
tyramine (found in wine and cheese)
mixed
ADE of tyramine
5-HT syndrome if on MAOI
ADE of norepinephrine
reflex bradycardia
isoproterenol works on which receptors?
B1, B2 ONLY
dobutamine works on which receptors?
B1 ONLY
increases contractions WITHOUT increasing HR
albuterol/salmeterol work on which receptors?
B2
terbutaline works on which receptors?
B2
ritodrine works on which receptors?
B2
ADE of albuterol/salmeterol
palpitations, tachycardia, hyperglycemia
clonidine works on which receptors?
a2 AGONIST
clonidine MOA
decreases presynaptic Ca++ levels in a2 R’s of brainstem, inhibiting NE release
apraclonidine works on which receptors?
a2 AGONIST
a-methyldopa works on which receptors?
a2 AGONIST
ADE of clonidine
sexual dysfunction
ADE of a-methyldopa
hemolytic anemia (+ Coombs test)
phenylephrine works on which receptors?
a1 AGONIST
ADE of phenylephrine
rebound congestion, HTN
cocaine works on which receptors?
a1, a2
what is a unique characteristic of cocaine?
it is the ONLY inherent vasoCONSTRICTOR
MOA of amphetamines
- stimulates monoamines (NE, dopamine, and 5-HT)
- blocks catecholamine reuptake