Flashcards in Pharmacodynamics Deck (52)
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1
what the BODY does to the the DRUG
pharmacoKINETICS
2
what the DRUG does to the BODY
pharmacoDYNAMICS
3
observed effect on the body
pharmacological effect
4
functional modification
pharmacological action
5
molecular modification
mechanism of action
6
drug goes through the cell membranes
diffusional transfer
7
drug goes through intercellular pores (between cells)
bulk flow transfer
8
proportional to concentration gradient
lipid diffusion (size: 100 - 1,000 MW)
9
inversely proportional to thickness of membrane
lipid diffusion
10
drug goes through aquaporins
aqueous diffusion
11
proportional to # of aquaporins AND concentration gradient
aqueous diffusion (size: less than or equal to 200 MW)
12
MW = 2,000 - 100,000 REQUIRES ENERGY
endocytosis/exocytosis
13
amount of drug in body compared to plasma concentration
volume of distribution (Vd)
14
Vd is _____, NOT _____
CONSTANT
dose-dependent
15
Vd formula
(D x F)/Cp
16
Vd
- 3L =
- 13L =
- 42L =
- more than 42L =
- plasma
- ECF
- TBW
- tissues
17
more protein-binding drugs cross placenta ____, and will NOT _____
SLOWLY
be filtered by glomeruli
18
D x F =
Total drug inside body
19
relates RATE of elimination to plasma concentration
clearance
20
CL total =
CL(hepatic) + CL(renal) + CL(after)
21
organ CL of a drug CANNOT exceed that of
MAXIMUM blood flow to that organ
22
makes drug more POLAR
biotransformation
23
phase I
CYP450 (oxidation, reduction, hydrolyses)
24
phase II
conjugation (MC: glucuronidation; acetylation)
25
CL(renal)
(F x U(drug))/P(drug)
26
CL(renal)
- 100-150mL/min =
- more than 150mL/min
- less than 100mL/min
- filtration
- secretion
- reabsorption (or protein binding)
27
amount of time taken for the plasma concentration of a drug to fall by 1/2
t(1/2) of elimination
28
t(1/2) is NOT dependent on?
DOSE
29
T =
infusion time
30
