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Flashcards in Pharmacodynamics Deck (52)
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1

what the BODY does to the the DRUG

pharmacoKINETICS

2

what the DRUG does to the BODY

pharmacoDYNAMICS

3

observed effect on the body

pharmacological effect

4

functional modification

pharmacological action

5

molecular modification

mechanism of action

6

drug goes through the cell membranes

diffusional transfer

7

drug goes through intercellular pores (between cells)

bulk flow transfer

8

proportional to concentration gradient

lipid diffusion (size: 100 - 1,000 MW)

9

inversely proportional to thickness of membrane

lipid diffusion

10

drug goes through aquaporins

aqueous diffusion

11

proportional to # of aquaporins AND concentration gradient

aqueous diffusion (size: less than or equal to 200 MW)

12

MW = 2,000 - 100,000 REQUIRES ENERGY

endocytosis/exocytosis

13

amount of drug in body compared to plasma concentration

volume of distribution (Vd)

14

Vd is _____, NOT _____

CONSTANT

dose-dependent

15

Vd formula

(D x F)/Cp

16

Vd

- 3L =
- 13L =
- 42L =
- more than 42L =

- plasma
- ECF
- TBW
- tissues

17

more protein-binding drugs cross placenta ____, and will NOT _____

SLOWLY

be filtered by glomeruli

18

D x F =

Total drug inside body

19

relates RATE of elimination to plasma concentration

clearance

20

CL total =

CL(hepatic) + CL(renal) + CL(after)

21

organ CL of a drug CANNOT exceed that of

MAXIMUM blood flow to that organ

22

makes drug more POLAR

biotransformation

23

phase I

CYP450 (oxidation, reduction, hydrolyses)

24

phase II

conjugation (MC: glucuronidation; acetylation)

25

CL(renal)

(F x U(drug))/P(drug)

26

CL(renal)

- 100-150mL/min =
- more than 150mL/min
- less than 100mL/min

- filtration
- secretion
- reabsorption (or protein binding)

27

amount of time taken for the plasma concentration of a drug to fall by 1/2

t(1/2) of elimination

28

t(1/2) is NOT dependent on?

DOSE

29

T =

infusion time

30

C(ss) is proportional to

D