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Unit 2 Pharm Drugs > Adrenergic Receptor Agonists > Flashcards

Adrenergic Receptor Agonists Flashcards

(55 cards)

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1
Q

Physiologic Effect at Alpha 1 Receptors

A
  1. Vasoconstriction (most smooth muscle responds to alpha 1 stimulation by constriction)
  2. Increased peripheral resistance
  3. Increased blood pressure
  4. Affects arterioles in skin, mucosa, viscera, kidneys, veins, uterus, and spleen
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2
Q

Physiologic Effect at Alpha 2 Receptors

A
  1. Inhibition of NE release and ACh release
  2. Inhibition of insulin release
  3. Affects presynaptic nerve endings and postsynaptic nerves in CNS
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3
Q

Physiologic Effect at Beta 1 Receptors

A
  1. Primarily affects the heart and kidneys
  2. Tachycardia
  3. Increased lipolysis
  4. Increased myocardial contractility
  5. Increased renin release
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4
Q

Physiologic Effect at Beta 2 Receptors

A
  1. Affects arterioles/arteries, bronchial muscle, pregnant uterus
  2. Vasodilation
  3. Slightly decreased peripheral resistance
  4. Bronchodilation
  5. Increased muscle and liver glycogenolysis
  6. Increased release of glucagon
  7. Relax uterine smooth muscle
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5
Q

Physiologic Effect at Dopamine 1 Receptors

A
  1. Dilates renal, splanchnic, and cerebral arterioles and increases blood flow to kidneys and other viscera
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6
Q

Norepinephrine (Levophed) Class

A

Non-selective agonist

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7
Q

Norepinephrine MOA

A

Agonist: α1, α2, β1

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8
Q

Norepinephrine Effects

A

Alpha 1: vasoconstriction and increased bp

Beta 1: Increased hr, conduction, and contractility

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9
Q

Norepinephrine Indications

A

Restore bp in acute hypotension or during cardiac arrest

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10
Q

Alpha Agonist Uses

A
  1. Control hemorrhage
  2. Contain local anesthetic
  3. Nasal decongestant
  4. Allergic (anaphylactic) shock
  5. Glaucoma
  6. Hypotension
  7. Shock
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11
Q

Norepinephrine Side Effects

A
  1. Hypertension
  2. Arrhythmias
  3. Headache
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12
Q

Epinephrine Class

A

Non-selective agonist

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13
Q

Epinephrine MOA

A

Agonist: α1, (α2), β1, β2

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14
Q

Epinephrine Indications

A
  1. Control hemorrhage
  2. Hypotension
  3. Shock
  4. Allergic reaction
  5. Cardiac Arrest
  6. AV Block
  7. Glaucoma
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15
Q

Epinephrine Effects

A
  1. Alpha 1: vasoconstriction and increased bp
  2. Beta 1: Increased heart rate and contractivilty
  3. Beta 2: vasodilation, decreased diastolic pressure, bronchodilation
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16
Q

Epinephrine Side Effects

A
  1. Palpitations
  2. Arrhythmias
  3. Headache
  4. Tremors
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17
Q

Amphetamine and Dextroamphetamine Class

A

Indirect Acting Agonist, CNS Stimulant

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18
Q

Amphetamine and Dextroamphetamine MOA

A

Increase amount of catecholamines in synaptic cleft by releasing intracellular stores of NE, dopamine, and seratonin

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19
Q

Amphetamine and Dextroamphetamine Effects

A
  1. Increased alertness
  2. Decreased fatigue
  3. Decreased appetite
  4. Insomnia
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20
Q

Amphetamine and Dextroamphetamine Side Effects

A

Though to be the result of adrenergic activity

  1. Vertigo
  2. HTN
  3. Confusion
  4. Nausea
  5. Diarrhea
  6. Insomnia
  7. Anxiety
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21
Q

Amphetamine and Dextroamphetamine Indications

A 
Amphetamine
1. Narcolepsy
2. Recreation
Dextroamphetamine
1. ADHD
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22
Q

Phenylephrine (Neo-synephrine) Class

A

α1-selective α agonist

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23
Q

Phenylephrine (Neo-synephrine) MOA

24
Q

Phenylephrine (Neo-synephrine) Indications

Study These Flashcards
A
  1. Nasal and ocular decongestant
  2. Treatment of drug induced hypotension
  3. Diet aids
25
Phenylephrine Side Effects
1. HTN | 2. Reflex bradycardia
26
Clonidine (Catapres) Class
α2-selective α agonist
27
Clonidine (Catapres) MOA
Agonist: CNS α2, decreases sympathetic outflow from vasomotor center
28
Clonidine (Catapres) Indications
1. HTN 2. Prevents withdrawal syndrome from opioids and alcohol 3. Shock
29
Clonidine (Catapres) Side Effects
1. Sedation | 2. Retention of salt and water
30
α-methyldopa (Aldomet) Class
α2-selective α agonist
31
α-methyldopa (Aldomet) MOA
Metabolite (a-methylnorepinephrine) activates CNS a2 receptors
32
α-methyldopa (Aldomet) Indications
1. Hypertension
33
α-methyldopa (Aldomet) Side Effects
1. Sedation
34
Isoproteranol (Isuprel) Class
Non-selective β agonist
35
Isoproteranol (Isuprel) MOA
Agonist: β1, β2 Beta 1: Increased heart rate, conduction, and contractility Beta 2: vasodilation and dec diastolic BP, bronchodilation
36
Isoproteranol (Isuprel) Indications
1. Cardiac Arrest 2. AV Block 3. Shock
37
Isoproteranol (Isuprel) Side Effects
1. Palpitations 2. Arrhythmias 3. Headache 4. Tremor
38
Dobutamine (Dobutrex) Class
β1-selective β agonist
39
Dobutamine (Dobutrex) MOA
Agonist: β1 | Increases cardiac contractility, cardiac output, and heart rate
40
Dobutamine (Dobutrex) Indications
1. Cardiogenic shock 2. Acute CHF 3. Heart Block
41
Albuterol (Proventil, Ventolin) Class
β2-selective β agonist
42
Albuterol (Proventil, Ventolin) MOA
Agonist: β2 | Relaxes bronchial, uterine, and vascular smooth muscle
43
Albuterol (Proventil, Ventolin) Indications
1. Prevent or treat bronchospasm 2. Mild exercise-induced asthma 3. COPD
44
Albuterol (Proventil, Ventolin) Side Effects
1. Tachycardia 2. Tremors 3. May mask progressively more severe inflammation
45
Terbutaline (Breathine) MOA
Adrenergic receptor agonist
46
Terbutaline (Breathine) Therapeutics
Prevent or reverse exercise induced bronchospasm, mild asthma, COPD, early labor
47
Terbutaline (Breathine) SE
1. Can mask progressively severe inflammation | 2. Tachycardia, muscle tremor
48
Terbutaline (Breathine) Misc
10-15 minutes to take action, 6-12 hours (max) of duration; nebulizer delivers more, but greater side effects; oral is least effective (requires more dose --> side effects); can be used night symptoms, but not ideal
49
Fenoldopam (Corlopam) MOA
Agonist, D1 receptor only
50
Fenoldopam (Carlopam) Therapeutics
Increase blood flow at renal, mesenteric, and cerebral arteries
51
Fenoldopam (Carlopam) Misc
~ 10 minute half life
52
Dopamine MOA
Agonist at D1, alpha 1, and Beta 1 receptors
53
Dopamine Therapeutics
Shock, renal failure, hypotension
54
Dopamine SE
Vasoconstriction at high doses
55
Dopamine Misc
Low dose = Direct @ D1 Receptors Medium dose = Direct @ Beta 1, some Indirect High dose = Direct @ Alpha 1, some Indirect

Unit 2 Pharm Drugs (9 decks)

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