Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Unit 2 Pharm Drugs > Cholinergic Receptor Inhibitors > Flashcards

Cholinergic Receptor Inhibitors Flashcards

(39 cards)

Start Studying
1
Q

Cholinergic Receptor MOA

A

Drugs that bind to cholinergic receptors, but do not trigger usual receptor mediated response

Types:

  1. Muscarinic receptor antagonists
  2. Ganglionic antagonists
  3. Neuromuscular blockers
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Muscarinic Receptor Antagonist MOA

A
  1. Inhibits muscarinic functions
  2. Primarily affects the parasympathetic NS
    excp. salivary and sweat glands
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Ganglionic Blockers MOA

A

Block nicotinic receptors for both the sympathetic and parasympathetic ganglia. Rarely used clinically bc response is wide and unpredictable

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Neuromuscular Junction Blockers MOA

A
  1. Block cholinergic transmission between motor nerve endings and nicotinic receptors on the neuromuscular end plate of skeletal muscle
  2. May be an agonist or antagonist
  3. Clinically useful during surgery as a muscle relaxant
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Common Side Effects of Muscarinic Receptor Antagonists

A
  1. Blurred vision
  2. Confusion
  3. Constipation
  4. Urinary Retention
  5. Mydriasis
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Atropine MOA

A

Muscarinic receptor antagonist via competitive inhibition

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Atropine Clinical Indications

A
  1. Bradycardia
  2. AV Block
  3. IBS
  4. Antisecretory agent
  5. Ocular inflammation
  6. Antidote for AChesterase inhibitor poisoning
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Atropine Effects on the Eye

A
  1. Eye exam relaxant
  2. Blocks all cholinergic activity in the eye
  3. Results in mydriasis, unresponsiveness to light and cycloplegia (inability to focus near vision)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Atropine Effects on the GI System

A
  1. Used as an antispasmodic to reduce activity of GI tract (relax GI)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Atropine Effects on the Urinary System

A
  1. Reduces hypermotility states of the bladder (relaxes bladder)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Atropine Effects on the Cardiovascular System

A
  1. Increase heart rate and conduction velocity

2. Causes smooth muscle relaxation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Atropine Effects on Secretory Activity

A
  1. Blocks salivary glands, decreasing secretion (used to dry secretions in upper and lower respiratory tracts prior to surgery)
  2. Produces xerostomia: dryness of mucous membranes
  3. Decreases activity of sweat and lacrimal glands
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Atropine Overdose Mnemonic

A
  1. Dry as a bone: decreased secretions, sweat, and tears
  2. Blind as a bat: blockade of pupillary accommodation, and excessive dilation
  3. Red as a beet: Dilation of cutaneous vessels in upper body
  4. Mad as a Hatter: Inhibition of CNS muscarinic receptors with confusion and hallucinations
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Benzetropine (Cogentin) MOA

A

Muscarinic receptor antagonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Benzetropine (Cogentin) Treatments

A
  1. Parkinson’s Disease: blockage of muscarinic receptors may restore neurotransmitter balance in basal ganglia
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Benzetropine (Cogentin) Side Effects

Study These Flashcards
A
  1. Mood Changes
  2. Xerostomia: dryness of mucous membranes
  3. Visual problems
17
Q

Scopalamine MOA

Study These Flashcards
A

Muscarinic receptor antagonist

18
Q

Scopalamine Treatments

Study These Flashcards
A

Motion sickness prophylaxis. Blocks short term memory

19
Q

Ipatropium (Atrovent) MOA

Study These Flashcards
A

Muscarinic receptor antagonist, causes bronchodilation and dries respiratory secretions

20
Q

Ipatropium (Atrovent) Treatments

Study These Flashcards
A

Asthma and COPD: Causes bronchodilation and dries respiratory secretions

21
Q

Titropium (Spiriva) MOA

Study These Flashcards
A

Muscarinic receptor antagonist, causes bronchodilation and dries respiratory secretions

22
Q

Titropium (Spiriva) Treatments

Study These Flashcards
A

Asthma and COPD: Causes bronchodilation and dries respiratory secretions

23
Q

Dicyclomine (Bentyl) MOA

Study These Flashcards
A

Muscarinic Receptor Antagonist

Blocks parasympathetic stimulation of enteric nervous system

24
Q

Dicyclomine Treatments

Study These Flashcards
A
  1. IBS. Reduces GI motility and tone, and relaxes smooth muscle
25
Tolterodine (Detrol)
Muscarinic Receptor Antagonist
26
Tolterodine (Detrol) Treatments
1. Transient cystitis 2. Post-operative bladder spasms 3. Incontinence
27
Tropicamide (Mydriacyl) MOA
Muscarinis Receptor Antagonist
28
Tropicamide (Mydriacyl) Treatments
1. Eye exam relaxant 2. Blocks all cholinergic activity in the eye 3. Results in mydriasis, unresponsiveness to light and cycloplegia (inability to focus near vision)
29
Tubocarine (Curare) MOA
Non-depolarizing Neuromuscular (Nicotinic) antagonist. Competitive inhibitor
30
Tubocarine (Curare) Treatments
1. Paralytic agent that lasts for 30-60 minutes | 2. Used as a surgical muscle relaxant w/o deep anesthesia
31
Succinylcholine (Anectine) MOA
1. Super-agonist: Overstimulation of nicotinic receptor, leading to desensitization of muscle unit to further ACh stimulation
32
Succinylcholine (Anectine) Treatments
1. Paralytic agent that lasts for 5-10 minutes | 2. Used as muscle relaxant for short procedures such as trachial intubation
33
Mivacurium (Mivacron) MOA
Non-depolarizing Neuromuscular (Nicotinic) antagonist. Competitive inhibitor
34
Mivacurium (Mivacron) Treatments
1. Used as a surgical muscle relaxant w/o deep anesthesia
35
Botulism Toxin A MOA
1. Blocks release of ACh at the synapse by inhibiting/degrading SNAP 25. SNAP 25 mediates the fusion of the synaptic vesicle with the presynaptic membrane
36
Botulism Toxin A Treatments
1. Can affect both voluntary and involuntary muscles 2. Cosmetic surgery: reduce frown lines and wrinkles 3. Reduce misalignment of eyes in strabismus 4. Achalasia: Improve esophageal contractions 5. Oromandibular dystonia (spasms of face, jaw, and neck)
37
Tolterodine (Detrol) MOA
Blocks muscarinic receptors
38
Tolterodine (Detrol) Therapeutics
1. Transient Cystitis | 2. Postoperative bladder spasms and incontinence
39
Tolterodine (Detrol) SE
General block of muscarinic functions

Unit 2 Pharm Drugs (9 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions