Adrenergic Receptor Antagonists Flashcards
(30 cards)
Phentolamine (Regitine) MOA
Alpha 1 and 2 receptor antagonist
Phentolamine (Regitine) Therapeutics
- Pheochromocytoma
- Raynaud’s
- Frostbite
Phentolamine (Regitine) SE
- Postural hypotension
2. Inhibit ejaculation
Prazosin (Minipress) MOA
Alpha 1 receptor antagonist
Prazosin (Minipress) Therapeutics
- Primary HTN
2. BPH
Prazosin (Minipress) SE
- Postural hypotension (usually first dose)
Terazosin (Hytrin) MOA
Alpha 1 antagonist
Terazosin (Hytrin) Therapeutics
- Primary HTN
2. BPH
Terazosin (Hytrin) SE
- Postural hypotension (usualy first dose)
Alpha receptor antagonist MOA
Reduces sympathetics tone of blood vessels leading to decrease peripheral resistance: decreases bp and reduces smooth muscle tone in bladder, neck, and prostate
Common suffix of alpha receptor antagonists
-zosin
Clinical indications of Alpha blockers
- HTN
2. BPH
First dose effect of alpha blockers
First dose may produce an exaggerated hypotensive response that results in syncope. May be minimized by slowly titrating dose or give dose at bedtime
Common suffix of beta receptor antagonists
-lol
Beta receptor antagonists MOA
Competitive inhibition
Clinical indications for use of beta blockers
- HTN
- Arrhythmias
- Angina
- Glaucoma
- Migraine prophylaxis
- Stage fright
- Chronic CHF (Use only 2nd or 3rd generation)
Major SE of Beta blockers
- Cardiac depression
2. Bronchoconstriction
Propanolol (Inderal) MOA
Beta 1 and 2 receptor antagonist. (Nonselective, first generation)
Propanolol (Inderal) Therapeutics
- Angina
- HTN
- Arrhythmias
Propanolol (Inderal) SE
- Bradycardia
- Bronchoconstriction
- Sexual dysfunction
Metoprolol (Lopressor) MOA
Beta 1 receptor antagonist. Second generation antagonist
Metoprolol (Lopressor) Therapeutics
- HTN
- Angina
- Arrhythmias
- CHF
Metoprolol (Lopressor) SE
- Bradycardia
- Bronchoconstriction
- Sexual dysfunction
Atenolol (Tenomin) MOA
Beta 1 receptor antagonist. Second generation
