Adrenoreceptors drugs Flashcards
(21 cards)
isoprenaline
selective beta adrenoreceptor agonist for the CVS for arrhythmias
phenylphrine
nasal decongestive acting as a direct a1 agonist in blood vessels and iris (causing dilation)
increases BP
clonidine
binds to a2 receptors on the presynaptic post-ganglia fiber reducing NA release
used for ADHD and Anxiety
lowers BP
adrenaline
act on all beta types for cardiac arrest and anaphylactic shock
dobutamine
act on b1 increasing contractability for heart failure, arrhythmias (tachy)
salbutamol
act on b2 relax lung smooth muscle for asthma
mirabegron
act on b3 in overactive bladder
Amphetamine
indirect agonist, reverse neural epinephrine transporter (NET) so more NA in synapse and removed from vesicles via VMAT
for ADHD and obesity
increase BP
Cocaine
indirect agonist, inhibits neural epinephrine transporter
Phenoxybenzamine
covalently bonds to a1 receptor
what effect does a1 antagonists have
hypotension which increases cardiac output causing tachycardia
Labetalol
antagonist of beta and a1 receptors for severe hypertension in pregnancy
Carvedilol
antagonist of beta and a1 receptors for heart failure
prazosin and doxazosin
anti-hypertensive causing vasodilation by acting as an a1 receptor antagonist
tamsulosin
urinary retentive
Yohimbine
vasodilator by acting as an a2 antagonist
propranolol
first generation beta blocker that is non-selective used for migraine treatment
what is the adverse effect of 1st gen beta blockers?
can lead to bronchoconstriction by binding to b2 in lungs bad for asthma, copd
atenolol
second generation b1 selective beta blocker for vasodilation
what do third generation beta blockers do
labetalol and carvedilol are b1 and b2 selective
what is wrong with beta blockers
reduces cardiac output by reducing constriction leading to less o2 around the body, leading to fatigue during exercise when O2 demand is high
- cardiac failure
- bradycardia
