Sympathetic NS drugs

Question 1

alpha- methyl-p-tyrosine

Answer 1

inhibitor targets tyrosine hydroxylase, less NA reducing BP in patients for catecholamine tumors

Question 2

carbidopa

Answer 2

inhibitor of Dopa decarboxylase, used for parkinsons disease as reduces L-DOPA peripheral effects

L-DOPA outside of brain can be converted into NA which would increase HR in patients

Question 3

Methyldopa

Answer 3

inhibits dopa carboxylase

a prodrug that is also metabolised to methyl-NA which competes with NA at alpha 2 receptors
(presynaptic causing inhibition of CAMP reducing Ca2+ so less NA released)

treatment for High BP

Question 4

Guanethidine

Answer 4

targets neural epinephrine transporter on presynaptic then competes for vesicle by transport to vesicular monoamine transporter (less NA in vesicle more degraded)

reducing BP

Question 5

Reserpine

Answer 5

inhibits vesicular epinephrine transporter

used as an anti-hypertensive

Question 6

adverse effects of Guanthidine and reserpine

Answer 6

sexual dysfunction, bradycardia and hypotension