Advanced Thyroid Cancer And Oncology Endocrinology Flashcards
Cancer number ___ in the US.
8
Cancer number ____ in US women.
5
Cancer number ____ for cancer-related cause of medical bankruptcy.
2
Which gene mutation predisposes to medullary thyroid cancer?
RET gene
Thyroid cancer incidence has increase ___ times in the last decade.
3
Thyroid cancer deaths have increased by ____ % in the last decade on a population-adjusted basis, rising faster than for any other cancer in the US.
~ 30%
The vast majority of differentiated thyroid cancer patients will never need therapy beyond surgery and radioactive iodine ablation.
Percentage?
> 95%
What two things can tell you if the disease is really RAI non-avid?
- Urine iodine concentration appropriately low
- TSH increment optimal for RAI administration
What is the target TSH suppression for metastatic disease?
If metastatic disease (thyroid cancer) is primarily confined to the bone then what two options should be considered?
- Focal radiotherapy
- Initiation of zoledronic acid or denosumab
Are VEGF-targeted kinase inhibitors (TKIs) orally bioavailable?
Yes
Most TKIs are ATP mimetic and bind to the ATP binding sites of kinases.
True or false?
True
Name 7 VEGF-targeted TKIs.
US FDA approved agents
- Sunitinib
- Sorafenib
- Pazopanib
- Axitinib
- Vandetanib
- Cabozantinib
- Lenvatinib
Are TKIs curative?
No
Name 7 common adverse effects of TKI - Pazopanib.
- Fatigue
- Skin hypopigmentation
- Nausea
- Diarrhea
- Anorexia
- Taste alterations
- Hypertension
