Adverse drug reactions

Question 1

Drugs which impair glucose tolerance

Answer 1

Thiazides
Steroids
Tacrolimus/Ciclosporin
IFN-a
Nicotinic acid
Antipsychotics

Question 2

Which drugs can cause a ‘SLIGHT’ impairment of glucose tolerance

Answer 2

Beta-blockers - use with caution in diabetics

Question 3

Drug induced urinary retention: causative drugs

Answer 3

TCAs - Amitryptiline
Anticholinergics - Anti-psychotics, antihistamines
Opioids
NSAIDS
Disopyramide

Question 4

Drugs causing pulmonary fibrosis:

Answer 4

AMIODARONE
Cytotoxics: busulphan, bleomycin
Methotrexate, sulfasalazine
Nitrofurantoin
Ergot-derived dopamine rececptor agonists (bromocriptine, cabergoline)

Question 5

Anti-rheumatoid drugs causing pulmonary fibrosis (2)

Answer 5

Methotrexate
Sulfasalazine

Question 6

TB drugs: Rifampicin side-effects

Answer 6

Red secretions
Liver enzyme inducer
Hepatitis
Flu-like symptoms

Question 7

TB drugs: Isoniazid side-effects

Answer 7

PERIPHERAL NEUROPATHY: prevent with pyridoxine
Hepatitis
AGRANULOCYTOSIS
Liver enzyme inducer

Question 8

TB drugs: Pyrazinamide side-effects

Answer 8

HYPERURICAEMIA - GOUT
Arthralgia
Myalgia
Hepatitis

Question 9

TB drugs: Ethambutol side effects

Answer 9

OPTIC NEURITIS - check visual acuity before and during treatment

Question 10

Dose of Ethambutol needs adjusted in patients with:

Answer 10

Renal failure