Adverse Drug Reactions Flashcards Preview

Pharmacology II - EXAM 2 > Adverse Drug Reactions > Flashcards

Flashcards in Adverse Drug Reactions Deck (130)
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1

What SERIOUS ADRs are associated with Triptans?

Coronary artery Vasospasm
Transient MI
MI
Ventricular Tachycardia/Fibrillation
HTN

2

What are more COMMON ADRs associated with Triptan use?

Paresthesias
Fatigue
Flushing
Chest Tightness
Swelling

3

What is St. Anthony's Fire?

What class of HA treatment medications is it associated with?

Associated with Ergotamines

Sx include......
Headache
Emesis
Diarrhea
Gangrene

4

Why is life-threatening ischemia associated with erogtamines?

When administered with CYP3A4 inhibitors (such as macrolides) it increases ergot levels leading to an increased risk of ischemia

5

What COMMON ADRs are associated with ergotamines?

Nausea
Emesis
Abdominal Pain
Weakness
Parethesias
Myalgia
Diarrhea
Chest Tightness

6

Does Butorphanol have addictive properties?

Yes

7

What COMMON ADRs are associate with Butorphanol?

(Remember: This is a partial opioid agonist)

Somnolence
Dizziness
Nausea
Emesis
Nasal Congestion
Insomnia
Respiratory Depression

8

What COMMON ADRs are associated with Fiorinal/Fioricet?

Nausea
Drowsiness
Dizziness
Abdominal Pain

9

If Fiorinal or Fioricet are overused (more than 2x weekly) what an occur?

Rebound-Headache from withdrawal

10

What ADRs are seen with IV metoclorpamide use for headache treatment?

Akathisia
Drowsiness

11

Why should you use PA-free formulations of butterbur?

Because the PA forms are associated with Hepatoxicity

12

What psychiatric warnings are associated with interferon beta?

Depression
Suicidal Ideation

13

What organotoxicity is associated with Interferon Beta?

Hepatotoxicity

14

Is CHF a potential warning of interferon beta?

Yes

15

What COMMON ADRs are seen with interferon Beta?

Flu-like Symptoms (Fever, mayalgia)
Insomina
Injection Site Reaction
Edema

16

Can you see HTN with Interferon Beta?

Yes

17

What can be given prior to injection of Interferon Beta to prevent the flu-like reaction?

Acetaminophen/Ibuprofen

30 minutes prior

18

What post-injection reactions are seen in Glutiramer Acetate?

Flushing
Chest Pain
Palpitations
Anxiety
Urticaria
Throat Constriction

19

Can a patient undergoing Glatiramer Acetate injections for MS treatment have Lipoatrophy or skin necrosis at the injection site?

Yes

20

What organotoxicity is associated with Mitoxantrone?

What should be done to monitor this?

Cardiotoxicity

Need Baseline LVeF
Repeat before each dose

21

What can be seen when Mitoxantrone is used for leukemia?

Myelosuppression

22

T/F: Secondary AML is seen with Mitoxantrone use

True

23

What are COMMON ADRs seen with Mitoxantrone?

Nausea
Alopecia
Menstrual Changes
UTI / URI

24

An MS patient presents complaining of a her urine now appearing a "blue-green" color.....

What medication is likely the culprit?

Mitoxantrone

25

Progressive Multifocal Leukoencephalopathy is associated with what MS medication?

Natalizumab

26

Would you expect to see leukopenia or leukocytosis with Dimethyl Fumarate?

Leukopenia

27

What ADRs are associated with Dimethyl Fumarate?

Flushing, Redness (Due to it's metabolite)
Rash
N/V/D
Abdominal Pain

28

What organotoxicity is NEWLY associated with Dimethyl Fumarate?

Hepatotoxicity

Normalizes after stopping medication

29

First-dose bradycardia is associated with what MS medication?

Fingolimod

EKG prior to dosing and monitor 6 hours after dose

30

Varicella Zoster is associated with what MS medication?

Fingolimod