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Pharmacology II - EXAM 2 > Mechanism of Actions > Flashcards

Flashcards in Mechanism of Actions Deck (53)
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1

What is the MOA of Pyridostigmine?

Prevents the destruction of acetylcholine by acetylcholinesterase allowing nerve impulses to travel across the neuromuscular junction

2

Although the MOA of ________ is mostly unknown it is thought to inhibit gluatamate release and inactivate voltage-gated Na+ channels in ALS patients.

Riluzole

3

What Parkinson's drug's MOA is listed below......

Restores synaptic concentrations of dopamine
Activates post-synaptic D2 (and some D1) receptors

Levodopa

4

T/F: Levodopa is not a pro-drug

False

It is the immediate precursor to dopamine

5

What is the MOA of Carbidopa?

Inhibits dopa-decarboxylase which metabolizes levodopa to dopamine.

This increases the bioavailability levodopa

6

Are the Ergot Dopamine Receptor Agonists (Bromocriptine, Cabergoline) selective or non-selective D2 receptor agonists?

Selective D2 receptor agonists

7

Pramipexole has a primary affinity for what dopamine receptor?

D3 (but also D2/4)

8

T/F: Ropinirole is a D2 receptor agonist

True

9

Which dopamine receptors does Amorphine act as an agonist at?

D1
D2

10

What is the MOA of Selegiline and Rasagiline?

Selective and irreversible inhibitors of MAO-B (which metabolizes dopamine)

11

What class of medication's MOA is described below......

Inhibit Catechol-O-Methyltranferase which typically metabolizes levodopa top 3-OMD in the brain and periphery

COMT Inhibitors

Talcapone
Entacapone

12

What Parkinson's medication's MOA is described below.....(hint: its an antivrial)

Potentiates dopaminergic function by modifying synthesis, release, or reuptake of dopamine

Amantadine

13

How do anticholinergics (Trihexyphenidyl, Benzotropine) work in Parkinson's treatment?

They block the excitatory cholinergic system that presents in dopamine deficiency which helps to alleviate motor dysfunction

14

What is the MOA of Pimavanserin?

Selective serotonin inverse agonist

High affinity at 5-HT2a

15

What ALZ medication's MOA is listed below.....

Reversible inhibition of cholinesterase to prevent acetylcholinesterase hydrolysis

Cholinesterase Inhibitors

Donepezil
Rivastigmine
Galantamine

16

Which ALZ medication is an uncompetitive NMDA receptor antagonist that works to increase glutamate release in the CNS?

Memantine

17

The MOA of _________ is mostly unknown, but its immunomodulatory and antiviral effects work to bind to a cell's surface receptors leading to expression of gene products and markers.

This is used in MS treatment

Interferon Beta

18

What is the MOA of Mitoxantrone?

Intercalate in DNA causing crosslinks and strand breaks
Topoisomerase Inhibitor (like fluoroquinolones)
Inhibits T-cells, B-Cells, and Cytokines

19

Which MS medication's MOS is described below....

Binds to leukocytes and inhibits adhesion which prevents movement across the BBB

Natalizumab

20

This MS medication is a Sphingosine 1-phosphate receptor modulator which keeps WBCs in the lymph nodes so they do not cross the BBB

Fingolimod

21

Which MS medication is a pyrimidine synthesis inhibitor which inhibits immune cells decreasing the number of lymphocytes in the CNS?

Teriflunomide

22

Dalfampridine is a _____-channel blocker, which _______ (increases/decreases) conduction through demyelinated axons

Potassium-Channel Blocker

Increases Conduction

23

How does Nudexta (Dextromethorphan/Quinidine) work?

Dexxtro: NMDA receptor antagonist

Quinidine: CYP2D6 Inhibitor, increases bioavailability of dextromethorphan, allowing it to cross the BBB

24

What class of headache medication's MOA is listed below.....

Serotonin receptor agonists (5-HT1 receptors)
Mediate vasoconstriction

Triptans

25

Are ergotamines selective or non-selective 5HT1 receptor agonists?

Do they act as vasodilators or vasoconstrictors?

Non-selective

Vasoconstrictors

26

Which receptors does DHE bind to?

5HT
NE
DA

27

Which second line medication for headache treatment is a partial opioid agonist?

Butorphanol

28

Which pain medication's MOA is described below.....

Mostly not well understood, but may block cytokines and prostagland release in the CNS

Acetaminophen (Tylenol)

29

What medication is a glutathione precursor used to metabolize MAPQI?

N-acetylcysteine

30

What class of pain medications inhibit COX 1 and 2 as well as prostaglandin synthase enzymes

Non-Steroidal Anti-inflammatory Drug (NSAIDs)