adverse effects Flashcards by Rebecca Lea

“glutides”

exenatide

(liraglutide, dulaglutide, abiglutide, lixisenatide)

acute pancreatitis

How well did you know this?

Not at all

Perfectly

estradiol

estrone

estriol

dose dependent:

thromoboembolism

increased blood clotting

gall bladder dz

migraines

HTN

How well did you know this?

Not at all

Perfectly

sudden ovarian enlargement

increased vascular permeability

rapid accumulation of fluids (peritoneal, pleural, pericardial)

hypovolemia

fever

shock

ovarian hyperstimulation syndrome

adverse effect of ART

How well did you know this?

Not at all

Perfectly

oxytocin

water intoxication at high concentration

uterine rupture in large dose

sinus bradycardia of the fetus

anaphylaxis

How well did you know this?

Not at all

Perfectly

acarbose, miglitol

(alpha glucosidase inhibitors)

flatulence

How well did you know this?

Not at all

Perfectly

clomiphene

(anti-estrogen)

multiple pregnancies

How well did you know this?

Not at all

Perfectly

danazol

(antiprogestin)

“very unpleasant”

weight gain, edema, acne, oily skin, HA

How well did you know this?

Not at all

Perfectly

nifedipine

hypotension

don’t combo with mag sulfate

How well did you know this?

Not at all

Perfectly

insulin

hypoglycemia

weight gain

cough/ bronchospasm (inhaled)

How well did you know this?

Not at all

Perfectly

exemestane

anastrozole

letrozole

(aromatase inhibitors)

menopausal sxs

(hot flashes)

How well did you know this?

Not at all

Perfectly

tamoxifen

(anti-estrogen)

increased risk of uterine CA

How well did you know this?

Not at all

Perfectly

“gliptins”

(sitagliptin, saxagliptin, linagliptin, alogliptin)

acute pancreatitis

How well did you know this?

Not at all

Perfectly

levothyroxine sodium

liothyronine sodium

hyperthyroidism

(tx by decreasing dose or take a day off)

How well did you know this?

Not at all

Perfectly

drugs that have interactions with thyroid hormones

WEST

warfarin

estrogen

steroids

tamoxifen

not mentioned but bolded in HO:

CRAP SIA

carbemazepine, rifampin, antacids, phenytoin, salicylates, iodine, anti-DM drugs

How well did you know this?

Not at all

Perfectly

carbost tromethamine

dinoprostone

(prostaglandins)

vomiting

diarrhea

How well did you know this?

Not at all

Perfectly

combo oral contraceptives drug interactions

3 antis + hypoglycemic + warfarin

antibiotics

warfarin

anticonvulsants

tricyclic antidepressants

oral hypoglycemic agents

How well did you know this?

Not at all

Perfectly

finasteride

dutasteride

(5 alpha reductase inhibitors)

Study These Flashcards

gynecomastia

“glitazones”

(pioglitazone, rosiglitazone)

Study These Flashcards

edema –> increased risk of HF

hypoglycemia

weight gain

bone fractures

fulvestrant

Study These Flashcards

hot flashes

GI sxs

anti DM drugs with the biggest hypoglycemia risk

Study These Flashcards

sulfonylureas

meglitinides

fertility tx

Study These Flashcards

*** ovarian hyperstimulation syndrome ***

multiple births

gynecomastia

Hormone Replacement Therapy

Study These Flashcards

endometrial/ uterine/ breast CA

hyperplasia

gallbladder dz

thromboembolism

the only DM drugs that are not oral and are SC instead

Study These Flashcards

GLP-1 agonists (glutides, exenatide)

pramlintide

sulfonylureas with the worst hypoglycemia

Study These Flashcards

glyburide

then first gens

repaglinide nateglinide

(same as sulfonylureas but no sulfa allergy) low hypoglycemia effects

**tolbutamide, chlorpropamide, tolazamide**

**hypoglycemia-** highest risk of any noninsulin tx weight gain sulfa allergy

**"gliflozin"** (canagliflozin, dapagliflozin, empagliflozin)

vag infections (fungal, UTI) polyuria AKI increased LDL

norethindrone/ norgestrel/ levonorgestrel ---- estradiol/ mestranol

**thromboembolic and blood clotting disorders** weight gain nausea edema depression HTN migraine MI

sulfonylurea with the least hypoglycemic effects

glipizide

propylthiouracil

Black Box Warning: liver injury acute liver failure

mag sulfate

hypotension don't combo with nifedipine

metformin

lactic acidosis diarrhea B12 deficiency

ergonovine maleate methylergonovine maleate (ergots)

fetal hypoxia DO NOT GIVE TO INDUCE LABOR

alendronate risendronate ibandronate zolendronate

**upper GI irritation** (why you need to be upright for 30 mins after taking orally) **osteonecrosis of the jaw** abdominal pain renal toxicity (IV)

indomethacin

closure of fetal ductus arteriosus

hydrocortisone, cortisone, prednisone, prednisolone, dexamethasone, fluticasone

**iatrogenic adrenal insufficiency** infection susceptibility peptic ulcers hyperglycemia eye effects (cataracts, increased IOP, glaucoma) CNS (restlessness, insomnia) osteoporosis muscle wasting and weakness

GnRH agonists (leuprolide, goserelin) GnRH antagonists (cetrorelix, ganirelix)

menopausal sxs (hot flashes, amenorrhea, decreased bone density) testicular atrophy

corticosteroids

ulcers **hyperglycemia** osteoporosis **chronic tx (more than 1-2 weeks) depresses HPA axis so you CANNOT DC abruptly, taper off**

raloxifene | (anti-estrogen)

hot flashes DVT

testosterone methyltestosterone

decrease testosterone (in men) masculinization (in women) pseudohermatphroditism (in fetus) both: oily skin decreased HDL psych changes

ketoconazole

gynecomastia libido decrease impotence

glyburide, glipizide, glimepiride

hypoglycemia- highest risk of any noninsulin tx weight gain sulfa allergy

adverse effects Flashcards

(42 cards)