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AED RX Flashcards

1
Q

What is imbalance btwn excite and inhib current in brain, which use NA, CL, K, and Ca ions across neuronal membranes?

A

Seizures- Focal and Generalized

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2
Q

What are the excitartory ions?

A

NA and CA

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3
Q

What are the inhibitory ions?

A

K+ hyperpolorize

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4
Q

What are the ligand gated particles that also excite or inhib membranes?

A

Glutamate-EXCITE, GABA-INHIB

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5
Q

Can you cure seizures?

A

NO. AEDs do not reverse or prevent or modifyGoals- DEC frequency 2. Find triggers 3. DEC injury 4. Improve QOL

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6
Q

When to start therapy?

A

First event on high risk 2. All with SECOND episode

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7
Q

What should be considered with all RX?

A

Gender, age, comorbities, preg, other meds, avail, cost

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8
Q

What are step if no change in seizure frequency?

A
  1. MaX DOSE-titrate 2. ADD Switch but taper down original and titrate other
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9
Q

What is EBM for children with partial/focal onset seizures?

A

OXC

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10
Q

What is EBM for Adults with partial onset seizures?

A

CBZ, LEV, PHT, ZNS

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11
Q

What is EBM for Elderly with partial onset seizures?

A

GBP, LTG

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12
Q

What is EBM for Children and Adults with General/2+ onset that is tonic-clonic seizures?

A

A grade- NONE poor evidence

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13
Q

What is EBM for Children with General/2+ onset absence seizures?

A

ESM, VPA. NONE For juveniles

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14
Q

what is MC used For partial/focal onset, 2/2 generalized, ?

A

CBZ, LTG, LEV, OXC, TMP, ZNS

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15
Q

What is MC used for PRIMARY GENERAL?

A

ESM- ABSENCE ONLY, LTG, LEV, TMP, VPA, ZNS

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16
Q

Use this drug for elderly epileptic focal?

A

LTG, LEV

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17
Q

Which drugs are ok for women of childbearing age?

A

LTG, LEV, ZNS- AVOID VALPO

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18
Q

What drug are AVOIDED for PRIMARY GEN seizure

A

GBP PReGBP, TGB, VGB

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19
Q

Which AED MOA is blocking Na channels?

A

PHY, CBZ, VPA

20
Q

Which AED MOA is blocking Ca channel?

21
Q

What other MOA of AED?

A

INC outward positiv of K or INC inhibtory GABA, DEC excitory Glutamate

22
Q

What is inital dose pf Phenytoin?

A

15-20 mg 3 didvided every 2-4hrs, MAX 2000

23
Q

CAN ER and DR divalproex be used interchangably?

A

NO, DR BID vs ER QD

24
Q

Which Meds need Hepatic Dose ADJ?

A

Phenobartial, PHY-monitor free unbound levels, Valporate

25
What AED need caution in Hepatie and Renal?
ESM-ethosuximide
26
SJS Diplopia, hyponatremia, and blood disorders is realted to...
CBZ
27
Mr. Victor's is have concerns with wt. gain, alopecia. His lab reveal INC bilirubin, INC ALT, and thrombocytopenia? What drug is he on?
Valporate
28
Aunt brenda has been more aggressive, Bipolar, not sleeping well lately. What could she be on?
ESM.- LABS- leukpenia, and Eosinophilla
29
What should you tell pts if on AED ADE?
All cause drowsy, caution driving
30
Whan do you moinitor drug level for PHY for partial seizures?
2 wks after new dose. IDEAL levels is 10-20. 1-2 for FREE UNBOUND
31
Name MC used new AEDs?
Gabapentin, Lamotrigne, Pregablin (lyrica
32
Lamotrigine and Topimated both work and treat which seizure?
Seizures- partial, gen tonic clonic, absenc myclonic. Blk NA channel. TOPA- adjuctive
33
What other new AED are adjuctive for Partial seizures?
PGBP and GBP
34
Which New AED DOES NOT cause drowsyness?
Lacosamide- avoid sever liver dz. Felbamate
35
If you Pt has h/o IBS which new AED is ideal?
PGBP and GBP, Clonazepam- no GI effects
36
Mr. Victor's has lab reveal INC bilirubin, INC ALT? What drug is ok for him d/t lack of hepatic dose ADJ?
GBP, LEV, PGBP, Tigabine- slow and low
37
What new AED required RENAL adj?
ALL- LTG, GBP, TPM, LEV, OXC, PGB, ZNS
38
What are the MC rare SE for new AEDs?
ADE sigificant LTG- steven johnson rash, GBP- wt gain, TPM-mental, glaucoma, wt loss, LEV-mood, OXC-Hyponatremis, blood d/o, PGB-vision, thromobcypeni, ZNS- confusion, parastheisa, rash
39
WHat drug enhances GABA, which will do what?
Clonazepam klonpin- Inhiitory for GAD. Also, STC adjuctn tonic and myoclonic sezures
40
WHich is only AED the open potassium channels?
Ezogabine
41
These AED hav serious side effects such as?
Tiga-SJS, seizure, Viga- irreversilby vision loss
42
Which med has no GI effect but has severe ARDS and dependence?
Clonazepam klonopin
43
Which new AED DOES NOT require RENAL adj?
Clobazam, Clonazepam, Tigabine, Phenyltoin, Valporate
44
What is a seizure lasting >5-30min w/ or w/o convuslsives? How is it Tx?
Status Epilepticus- supportive, O2, venilator. Children- Lorazepam IV, rectal gel. Maintencne PHY/ PB pheonbarb
45
What RX is MOA unkonw, Hihg CYP interactison, treated for Lennox Gasstaut Dravet?
Epidiolex- Cannabidiol. NO effect on cannabidol receptor

SUMPHARM (26 decks)

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