Agents and their Indications Flashcards
(38 cards)
used for many oral toxins
Activated charcoal with sorbitol
sweetener, can act as a laxative and helps eliminate the poisons in the body
Sorbitol
MOA of Activated Charcoal
Adsorption
What type of antidote is AC?
Mechanical antidote
organophosphate and carbamate insecticides, some mushrooms toxicity
Atropine
Should be given within 24 hours. If not given immediately, the toxic effect of organophosphate will be irreversible.
Atropine
theophylline toxicity
beta blockers
Serotonin antagonist used for serotonin syndrome
Cyproheptadine
Used for CCB toxicity and black widow spider bites
Calcium chloride
Used for hydrofluoric acid toxicity
Calcium gluconate
Hydrofluoric acid can cause
painless burns
Hydrogen fluoride can cause
damage to lungs and cornea of the eyes
For heavy metal poisoning
chelators
Examples of chelators
EDTA, dimercaprol (BAL), penicillamine, 2,3 -dimercaptosuccinic acid (DMSA, succimer)
For cyanide poisoning
Amyl nitrite, sodium nitrite, or thiosulfate
For Iron poisoning
Deferoxamine mesylate
For digoxin poisoning
Digoxin Immune Fab antibody (Digibind and Digifab)
For extrapyramidal reactions associated with antipsychotic and antiparkinsons
Diphenhydramine HCl (antihistamine) & Benztropine (anticholinergic)
For ethylene glycol poisoning and
methanol poisoning
Ethanol or fomepizole
For benzodiazepine poisoning
Flumazenil
What type of antagonism does Flumazenil exhibits?
Competitive antagonism
for beta-blocker poisoning and calcium channel blocker poisoning
Glucagon
Carbon monoxide poisoning and cyanide poisoning
100% oxygen or hyperbaric oxygen therapy (HBOT)
For methotrexate and trimethoprim poisoning
Leucovorin