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AU 15- Periodontology Exam 2 > Aggressive Periodontitis > Flashcards

Flashcards in Aggressive Periodontitis Deck (35):
1

What are four important features of aggressive periodontitis?

-Patient is otherwise HEALTHY clinically
-Characteristic RAPID bone and attachment loss
-INCONSISTENCY with plaque and calculus
-FAMILIAL aggregation

2

What are the two sub-classifications of Aggressive Periodontitis?

Localized Aggressive
Generalized Aggressive

3

LAP most frequently occurs in patients between _____ and _____ years old.

puberty-->20 years old

4

GAP affects patients under the age of _______ but may occur in older patients also.

30

5

In localized aggressive periodontitis, at least ______ _____ must be affected and no more than two teeth other than _____ and _____.

at least one first molar
no more than 2 other teeth besides molars/incisors

6

In GAP, there must be at least _____ permanent teeth other than ______ and ______ that are affected.

at least 3 teeth other than first molars and incisors

7

Which form of aggressive periodontitis (LAP or GAP) is characterized by a robust serum antibody response?

LAP = serum antibody response

8

True or False: GAP has a moderate serum antibody response.

False...POOR serum antibody response

9

Which form of aggressive periodontitis is characterized by intense gingival inflammation and which has relatively less gingival inflammation?

Intense inflammation: GAP ("inflammation causes gaps")
Less inflammation: LAP

10

True or False: Localized Aggressive Periodontitis is characterized by episodic destruction of attachment and bone.

False, GAP has episodic nature

11

How do you determine rate of bone loss?

Comparison of serial radiographs (aggressive is 3-4 times faster than chronic)

12

True or False: Prevalence of Aggressive Periodontitis in the primary dentition is 0.9% to 4.5%

True

13

True or False: Prevalence of Aggressive Periodontitis in the United States is 5%

False, below 1% in the U.S.

14

True or False: Both types of Aggressive Periodontitis are more prevalent among African Americans (2.6%)

True

15

There is a direct link between ______ ______ microbes and localized aggressive periodontitis.

A.a

16

A.a and, more particularly, the _____ clone or serotype ____ is highly associated with LAP.

JP2 clone (high in African American populations)
serotype B

17

True or False: A.a is motile.

False

18

True or False: A.a in anaerobic.

False, it's a facultative anaerobe

19

What are the 4 virulence factors associated with A.a?

1. Leukotoxins
2. LPS
3. Collagenase
4. Immunosuppressive Factors

20

A.a will translocate across the _____ and invade the _____.

junctional epithelium
connective tissue

21

What is the action of leukotoxin?

kills PMNs and macrophages

22

Which two host responses are suppressed by A.a's immunosuppressive factors?

Lymphocytes
Chemotaxis

23

P.gingivalis is a gram___ microbe that is ______ and _______. P.gingivalis is associated with _____ aggressive periodontitis.

negative
anaerobic
nonmotile
generalized

24

What are the three virulence factors associated with P.gingivalis?

1. Proteinase (gingipains and collagenase)
2. LPS (activates PGs, TNFalpha, and IL-1beta)
3. Inhibition of IL-8 (decreases chemotaxis of PMNs)

=inhibition of host responses

25

True or False: LAP is most likely a genetic polymorphism.

True

26

What is the proposed inheritance mode for LAP?

autosomal dominant

27

There are significantly higher levels of _______ in gingival crevicular fluid in patients with LAP

prostaglandin E2

28

True or False: There are high titers and high avidity of IgA in localized aggressive periodontitis.

False, high titers of IgG2

29

True or False: GAP patients have high levels of antibodies against P.gingivalis.

False, LOW levels of antibodies against P.g

30

LAP is associated with impaired ______ function.

neutrophil

31

Diagnosing AP: If there is high A.a? If there is high P.g?

A.a = LAP
P.g = GAP

32

Diagnosing AP: High crevicular PGE2 levels? High titers of IgG? Low levels of P.g antibody?

high PGE2 = LAP
high IgG2 = LAP
low P.g Ab = GAP

33

Levels of antibody against A.a are higher in ______ than in blood.

sulcular fluid > peripheral blood

34

What are the two antibiotic cocktails that are prescribed for aggressive periodontitis?

Amoxicillin + Metranidazole (500mg 3x per day)
Ciprofloxacin + Metranidazole

35

Metranidazole is effective against ______ but not _____ when used on its own.

*P.g
(not) A.a