Agsa Pharma 2nd SEM FINALS Flashcards
(92 cards)
What is the primary physiological role of vasopressin?
a. Regulation of blood glucose levels
b. Stimulation of uterine contractions during labor
c. Control of blood pressure and water balance
d. Promotion of bone growth
c. Control of blood pressure and water balance
In this phase of clinical trial, the drug is studied in patients with the target disease to determine its efficacy (“proof of concept”), and the doses to be used in any follow-on trials. A modest number of patients (100–200) are studied in detail.
a. Phase 1
b. Phase 2
c. Phase 3
d. Phase 4
b. Phase 2
Sam had been taking prednisone for his ulcerative colitis but failed to take it for the last week. He suddenly had symptoms of lightheadedness or dizziness, weakness, sweating, abdominal pain, nausea and vomiting suggestive of adrenal insufficiency. This drug should be given
a. Prednisone
b. Fludrocortisone
c. Mifepristone
d. Spironolactone
b. Fludrocortisone
A 14-year-old boy who has diabetes and is insulin dependent is brought to the emergency department after collapsing at a baseball game. His blood sugar is 463 mg/dL by finger stick. Which of the following routes of administration would be most efficacious for medications to bring the blood sugar down?
a. Intramuscular
b. Intravenous
c. Oral
d. Subcutaneous
b. Intravenous
Antifungal of choice for the treatment of cryptococcal meningitis?
a. Voriconazole
b. Nitroimidazole
c. Fluconazole
d. Itraconazole
c. Fluconazole
Poisoning from this organic compound is now very rare, in large part because of the worldwide phase-out as antiknock additives in gasoline. This heavy metal is readily absorbed through the skin and lungs and the primary signs of intoxication include hallucinations, headache, irritability, convulsions and coma. Treatment consists of decontamination and seizure control.
a. Lead
b. Arsenic
c. Mercury
d. Iron
a. Lead
The following statements are TRUE regarding bactericidal antibiotics EXCEPT:
a. MBC > MIC
b. It is effective in infections when host defenses are poor
c. It requires host defense mechanism
d. It causes bacterial death
c. It requires host defense mechanism
Osmotic laxatives, such as lactulose exert their therapeutic effects by:
a. Stimulating peristalsis in the gastrointestinal tract
b. Softening stool consistency
c. Increasing water content in the stool
d. Inhibiting water absorption in the colon
c. Increasing water content in the stool
The triad of cinchonism, hypoglycemia and hypotension are adverse effects attributed to?
a. Quinine
b. Mefloquine
c. Chloroquine
d. Primaquine
a. Quinine
Which of the following drug classes act on cell microtubules?
a. Platinum analogs
b. Alkylating agents
c. Taxanes
d. Anthracyclines
c. Taxanes
Which of the following drugs may cause hemolytic-uremic syndrome as its adverse effect?
a. Mitomycin and Gemcitabine
b. Doxorubicin and Paclitaxel
c. Sunitinib and Dacarbazine
d. Cytarabine and 5-fluorouracil
a. Mitomycin and Gemcitabine
Which antithyroid drug has a black box warning of causing severe hepatitis sometimes even resulting to death?
a. Propylthiouracil (PTU)
b. Methimazole
c. Radioactive iodine
d. Levothyroxine
a. Propylthiouracil (PTU)
Which of the following laxatives works by increasing bulk and water content in the stool, thereby promoting bowel movements?
a. Bisacodyl
b. Docusate sodium
c. Polyethylene glycol
d. Psyllium
d. Psyllium
This environmental pollutant has been widely used in manufacturing and building. All forms have been shown to cause progressive fibrotic lung disease, lung cancer, and mesothelioma.
a. Asbestos
b. Dioxins
c. Polychlorinated Biphenyls
d. Manganese
a. Asbestos
Which of the following drugs is NOT typically included in the four-drug regimen for the eradication of H. pylori infection?
a. Tetracycline
b. Bismuth subsalicylate
c. Metronidazole
d. Famotidine
d. Famotidine
Inflammatory bowel disease (IBD) encompasses two main disorders, namely:
a. Crohn’s disease and ulcerative colitis
b. Peptic ulcer disease and diverticulitis
c. Gastroesophageal reflux disease (GERD) and irritable bowel syndrome (IBS)
d. Gastroparesis and celiac disease
a. Crohn’s disease and ulcerative colitis
Luke has elevated blood pressure of 160/100 for the past 3 weeks. Which of the following when elevated contributes to his blood pressure
a. Aldosterone
b. Prednisone
c. Dexamethasone
d. Fludrocortisone
a. Aldosterone
Short bowel syndrome (SBS) is characterized by:
a. Excessive length of the small intestine
b. Insufficient length of the small intestine
c. Malformation of the large intestine
d. Inflammation of the colon
b. Insufficient length of the small intestine
Which of the following is NOT a mechanism of action of proton pump inhibitors (PPIs)?
a. Inhibition of gastric acid secretion by blocking H2 receptors
b. Inhibition of the H+/K+ ATPase pump in gastric parietal cells
c. Suppression of basal and stimulated acid secretion
d. Irreversible inhibition of the final step of acid secretion
a. Inhibition of gastric acid secretion by blocking H2 receptors
Which of the following is a potential adverse effect of thionamide antithyroid drugs?
a. Hypothyroidism
b. Hyperkalemia
c. Hepatotoxicity
d. Hypokalemia
c. Hepatotoxicity
P.K. a 60-year-old immunocompromised male is diagnosed and confirmed with Clostridium difficile colitis. Which of these drugs would best treat his condition?
a. IV Fidaxomycin
b. Oral Rifaximin
c. Oral Metronidazole
d. IV Vancomycin
c. Oral Metronidazole
Which antithyroid drug is preferred during the first trimester of pregnancy due to its lower risk of causing fetal hypothyroidism?
a. Propylthiouracil (PTU)
b. Methimazole
c. Radioactive iodine
d. Levothyroxine
a. Propylthiouracil (PTU)
Sam is 32 year old smoker, sp kidney transplant and heart failure on oral contraceptives, prednisone and aldosterone . After a long flight from the United States she suddenly had difficulty of breathing. She was rushed to the emergency room. Spo2 was 88%, HR 122, normal cardiac exam, clear breath sounds. Her condition was likely due to
a. Aldosterone
b. Oral contraceptives
c. Prednisone
d. Spironolactone
b. Oral contraceptives
Which of the following medications should be avoided in patients with a history of peptic ulcer disease?
a. Nonsteroidal anti-inflammatory drugs (NSAIDs)
b. Proton pump inhibitors (PPIs)
c. Antacids
d. H2-receptor antagonists
a. Nonsteroidal anti-inflammatory drugs (NSAIDs)