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Flashcards in AIDS Deck (19)
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1

what are stages of HIV infection?

- stage 1 = acute HIV infection
- stage 2 = clinical latency (HIV inactivity or dormancy)
- stage 3 = AIDS (aquired immunodeficiency syndrome)

2

indicator diseases of AIDS

- PJP
- pulmonary TB
- KS
- extra-pulmonary cryptococcosis
- HIV encephalopathy
- NHL
- CMV
- HSV
coccidiodomycosis
- toxoplasmosis
- candidiasis
- non-typhoid salmonella bacteremia

3

definition of AIDS

- CD4+ < 200 cells/mm3
- CD4+ < 14% of all lymphocytes
- 1 or more AIDS defining illness

4

commonest reason for HIV-infected pts to be admitted to ICU

respiratory failure 2/2 PJP

5

PJP PNA presentation

- prolonged prodromal illness
- fever
- dry cough
- pleuritic, retrosternal pain

6

PJP PNA presentation in more advanced cases

- DOE
- lethargy
- weight loss

7

cxr findings for PJP PNA

either normal or if severe than faint b/l interstitial infiltrates similar to ARDS

8

definitive dx of PJP PNA

organism identified in one of the following
- induced sputum
- BAL
- transbronchial lung bx
- open lung biopsy

9

lab value that can be elevated in PJP PNA

LDH

10

complication of PJP PNA

PTX

11

mortality of PJP a/w PTX

10%

12

tx of PJP PNA

iv smx/tmp or pentamidine

13

main problem w/ PJP tx

high incidience of adverse effects, > 50%

14

adverse effects from smx/tmp

- nausea/vomiting
- diarrhea
- rashes
- glossitis
- erythema multiforme
- toxic epidermal necrosis
- pancreatitis
- blood dyscrasias
- pseudomembranous colitis
- jaundice
- hepatic necrosis

15

adverse effects from pentamidine

- hypoglycemia/hyperglycemia
- pancreatitis
- arrhythmias
- AKI
- hypocalcemia
- blood dyscrasias
- rashes
- bronchoconstriction
- orthostatic hypotension

16

how long does it take for PJP PNA pts to get better once they start tx?

end of first week

17

do some pts initially get worse when PJP tx is started?

yes (maybe from increased lung capillary permeability and edema)

18

tx shown to reduce risk of respiratory failure and death in pts w/ AIDS

glucocorticoids

- need to be given w/i 24-72 hours

19

when are glucocorticoids indicated in PJP PNA?

-