AIDs/HIV Flashcards
What is the most common mode of exposure for AIDS
Sexual Transmission across the exposed mucosal epithelium
How does the HIV virus work?
The proliferation of infected CD4+ T lymphocytes + migration of infected macrophages = appearance of viral RNA in the bloodstream
What is the MC transmission of HIV to healthcare workers
In inadvertent needle stick.
What is the best measure of the status of the immune system and disease progression of HIV?
CD4 Cell Count- Measures the progression after person ins already infected.
What does the CD4 cell count tell you?
Demonstrates the risk of opportunistic infections.
What is used to measure the response to and efficacy of HAART therapy. gives corresponding predictive information to the CD4 count?
Viral Load Serology
What is the presentation of acute HIV infection?
Initially appears with a syndrome similar to that seen with mononucleosis
Occurs about 2-4 weeks after exposure to HIV
What are the presenting symptoms of HIV?
Just like Cancer
Fever, Night Sweats, Weight loss
When does it go from HIV to AIDs
CD4 < 200
What is the risk of HIV transmission with prolonged breast feeding?
50%
What is the postexposure prophylaxis recommended therapy?
emtricitabine, raltegravir, and tenofovir
What are the SE of the antiretroviral therapy NRTI’s
Bone marrow suppression - Check CBC
Peripheral neuropathy
Megaloblastic anemia (ZDV)
Pancreatitis (ddl)
What SE for NNRTIs (Nonnucleoside reverse transcriptase inhibitors have CNS symtpms
Efavirenz
What Protease inhibior cases cyrstal induced nephropathy>?
Indinavir
What is the link between HIV and TB?
HIV-positive patients co-infected with tuberculosis have 20-30x greater risk for development of active tuberculosis and subsequent infectious state compared with HIV-negative patients