Alimentary Canals Flashcards

(175 cards)

1
Q

What are the predominant type of diseases vary among different species?

A

-Dogs and cats develop alimentary neoplasia more often than

farm animals.

  • Ruminants and pigs develop a wide range of infectious diseases often poorly controlled by vaccination.
  • Horses are prone to intestinal displacementscolic
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2
Q

Portals of Entry of pathogenic agents

A

 Ingestion (most common)
 Coughed up by the lungs and swallowed  Systemic hematogenous route
 Migration through the body (parasites)

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3
Q

Defense Mechanisms

A

 Saliva
 Resident flora and fauna
 Gastric pH
 Secreted immunoglobulins
 Vomiting
 Intestinal proteolytic enzymes
 Phagocytes and other effector cells within the mucosa/ submucosa  High rate of epithelial turnover
 Increased peristalsis resulting in diarrhea

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4
Q

Name and what the complication is

A

In palatoschisis there is a central
defect in the midline fusion of the palatine shelves resulting in communication between the oral and nasal cavity.

Caused by Veratrum californicum

Complication- aspiration pneumonia

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5
Q
A

Cheiloschisis (“harelip”) - calf

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6
Q

What is a consequence of this and what is it called?

A

Prehension, prone to infection

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7
Q

Malocclussions

A

Failure to the upper and lower incisors to interdigitate properly

 May result in difficulties in the prehension and mastication of food.

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8
Q
A

Short lower jaw (brachygnathia)

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9
Q
A

Foal, prognathia is protrusion of the lower jaw.

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10
Q
A

Dental attrition (loss of tooth structure caused by mastication).

The degree of tooth wear depends on the tooth, the animal species and the types of food. Abnormal wearing is most common in herbivores results in “step mouth”.

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11
Q
A

 Periodontal disease

 Resident bacterial films and the acid and enzymes they produce lead to enamel, gingival and periodontal ligament damage.

 Dental plaque

 Dental calculus (tartar mineralized dental plaque)

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12
Q

primary diseases of the oral cavity

A

Primary diseases are rare; the exception is Actinobacillosis (Actinobacillus lignieresii) or pyogranulatmous glossitis chronic stomatitis – the tongue is often involved:

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13
Q
A

Actinobacillosis (Actinobacillus lignieresii)

Pyogranulatous glossitis

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14
Q
A

Radiating clubs of amorphous eosinophilic material: Splendore-Hoeppli phenomenum

A. Lignieresii is a Gram-negative rod

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15
Q
A

Thrush (Candidiasis)

 Candidaspp.(eg.C.albicans)

 Often is observed young animals treated with antibiotics for long periods of time, or animals with underlying debilitating diseases

AFFECTS THE KERATIN(SILVER STAIN)- RESULTS IN HYPERKERTAIN

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16
Q
A

Lingual lesions are often a manifestation of systemic disease like renal disease (uremic glossitis), BVD or other viral infections like FMD (discussed later).

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17
Q
A

Lymphoplasmacytic gingivitis, stomatitis –cat Many cats are FeLV or FIV positive.

IMMUNE MEDIATED

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18
Q
A

Feline chronic gingivo-stomatitis (FCGS). Cinical signs: oral pain, dysphagia, ptyalism and weight loss.
Etiology: unclear. Dental plaque, FCV, and immune-mediated mechanisms appear to be involved. FCGS is also common in FIV positive cats.

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19
Q
A

Chronic ulcerative (lympho-plasmacytic) paradental stomatitis – Most common in older dogs

Thickening of the gingivia

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20
Q

Vesicular stomatitides

A

Vesicle: a raised lesion (up to 1 cm in the largest dimension) filled with clear (serous) fluid located within the epithelium or between the epithelium and lamina propria). A larger lesion is referred as bulla.

If observed in the oral cavity of dogs & cats:

Rule out immune-mediated diseases

In cats they are often the result of calicivirus infection

If observed in food/ large animals:

• Rule out major viral diseases which are usually non-fatal but result in huge economic loss.

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21
Q
A

Viral vesicular stomatitides

Pathogenesis: viral-induced epithelial damage intracellular edema in keratinocytes (ballooning degeneration)vesiclesbullaerupture leads to erosion and ulceration.

Targets epithelial cells

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22
Q
A

Vesicular glossitis – Cat, calicivirus infection.

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23
Q

Vesicular Diseases

A
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24
Q
A

FMD

 Exotic (Foreign) Animal Disease. Highly contagious with high morbidity and low mortality.

 Virus ingestion/ inhalation

pharynx  viremia  Oral mucosa & epidermal siteslesions

develop in areas subjected to mechanical injury

 Clinical signs: drooling saliva (ptyalism), lameness

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25
FMD
26
What is a lesion with FMD that can be seen in young animals?
Young animals: “tiger heart” multiple stripes, FMD Myocardial necrosis
27
Severe lameness, pig - FMD
28
Vesicular exanthema (calicivirus) Only in pigs DDx: FMD
29
What two disesases cause erosive-ulcerative stomatidies
BVD (Pestivirus) Multi-focal of mucousal ulceration MCF- Herpes; targets endothelium
30
Bovine papular stomatitis. Etiology: Parapoxvirus Epithelial hyperplasia “Coin-shaped papules and ulcers”, The virus is closely related to pseudocowpox virus that causes “milker’s nodules in humans (hands).  Papules on the nares, muzzle, oral cavity. Usually in immunosuppressed individuals
31
Bovine papular stomatitis. Etiology: Parapoxvirus
32
Contagious Ecthyma, also known as Contagious viral pustular dermatitis, Orf, or “sore mouth” Worldwide distribution. The cause is a parapoxvirus. Results in loss of condition since affected animals “neither suckle nor graze”. High morbidity and low mortality. Mainly in lambs and goat kids 3 to 6 months of age. ZOONOTIC; SHEEP AND GOATS; get from mom's teat
33
Contagious Ecthyma. AVC. Lesions usually develop in sites of trauma (corners of the mouth, mammary gland, coronary bands, etc.). It is a zoonotic disease.
34
Calf, Pathology Museum, FVSc, University of Liverpool Oral Necrobacillosis, Fusobacterium necrophorum filamentous anerobic bacteria; bacterial toxins are responsible for the severe lesions
35
Oral necrobacillosis- necrotizing!, Calf, AVC. ``Calf Diphtheria`` Fusobacterium PAS, filamentous bacteria.
36
Feline eosinophilic granuloma – complex (includes eosinophilic granuloma, labial and rodent ulcer).
37
cat, eosinophilic ulcer, palate.
38
Feline eosinophilic granulomas. Young UCVM cats (VSRS).
39
Feline eosinophilic granulomas. Young UCVM cats.
40
Gingival hyperplasia
41
Fibromatous epulis, dog Epulis: Tumors of the periodontal ligament – type stroma (whether or no they are true neoplasms is still controversial)
42
Canine oral papillomatosis Papovavirus-induced papilliform or cauliflower-type lesions (“warts”) in the lips and oral mucosa. It is transmissible and usually affects animals younger than 1 year-old. Lesions regress spontaneously and immunity is long-lasting. Immunosupression; transmisble to young animals
43
Oral papilloma: Verrucous lesion composed of thick keratinized stratified squamous epithelium covering a pedunculate connective tissue core.
44
Oral melanomas. Most common in dogs. Around 90% of oral melanomas in dogs are malignant. Smaller breed and oral pigmentation are predisposing factors. Hematogenous and lymphatic routes
45
Amelanotic melanoma, dog no melanin pigment; more invasive b/c cells are less differentiated
46
Oral melanoma, dog
47
Melanoma, dog – pulmonary metastases,
48
Squamous cell carcinoma, tongue, dog
49
Fibrosarcoma – palate and maxilla QH gelding, AVC
50
Congenital megaesophagus –persistent right aortic arch (vascular ring) - puppy consequences: - aspiration pneumonia - vomiting without any digestion
51
Megaesophagus can also be acquired – most common in dogs. idopathic or myasthenia gravis 􏰃􏰄􏰀􏰅􏰆􏰇􏰀􏰈􏰉􏰀􏰊􏰋􏰊􏰌􏰍􏰆􏰄􏰎􏰊􏰅􏰀􏰌􏰏􏰀􏰆􏰀􏰐􏰆􏰇􏰊􏰑􏰉􏰒􏰄􏰆􏰄􏰊􏰌􏰇􏰀􏰌􏰑􏰀􏰐􏰓􏰆􏰒􏰄􏰎􏰉􏰇􏰊􏰆􏰀􏰔􏰏􏰆􏰕􏰊􏰒􏰀 􏰃􏰄􏰀􏰅􏰆􏰇􏰀􏰈􏰉􏰀􏰊􏰋􏰊􏰌􏰍􏰆􏰄􏰎􏰊􏰅􏰀􏰌􏰏􏰀􏰆􏰀􏰐􏰆􏰇􏰊􏰑􏰉􏰒􏰄􏰆􏰄􏰊􏰌􏰇􏰀􏰌􏰑􏰀􏰐􏰓􏰆􏰒􏰄􏰎􏰉􏰇􏰊􏰆􏰀􏰔􏰏􏰆􏰕􏰊􏰒􏰀 􏰃􏰄􏰀􏰅􏰆􏰇􏰀􏰈􏰉􏰀􏰊􏰋􏰊􏰌􏰍􏰆􏰄􏰎􏰊􏰅􏰀􏰌􏰏􏰀􏰆􏰀􏰐􏰆􏰇􏰊􏰑􏰉􏰒􏰄􏰆􏰄􏰊􏰌􏰇􏰀􏰌􏰑􏰀􏰐􏰓􏰆􏰒􏰄􏰎􏰉􏰇􏰊􏰆􏰀􏰔􏰏􏰆􏰕􏰊􏰒
52
Choke, foreign body stuck when removed you will see the esophagus necrosis and degeneration
53
Reflux-esophagitis, horse whitish color- keratin to protect against refluxed gastric acid -hyperkeratosis primary with secondary erosins
54
Erosive-ulcerative esophagitis, BVD or necrotizing
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􏰖􏰉􏰒􏰗􏰘􏰄􏰒􏰀􏰊􏰇􏰀􏰅􏰎􏰏􏰌􏰇􏰊􏰅􏰀􏰙􏰔􏰏􏰆􏰇􏰗􏰘􏰌􏰐􏰆􏰄􏰌􏰗􏰒􏰚􏰀􏰉􏰒􏰌􏰍􏰎􏰆􏰔􏰊􏰄􏰊􏰒􏰀􏰙􏰛􏰚􏰀􏰜􏰎􏰊􏰅􏰎􏰀􏰌􏰅􏰅􏰆􏰒􏰊􏰌􏰇􏰆􏰘􏰘􏰓􏰀􏰘􏰉􏰆􏰋􏰀􏰄􏰌􏰀􏰇􏰉􏰌􏰍􏰘􏰆􏰒􏰄􏰊􏰅􏰀 􏰄􏰏􏰆􏰇􏰒􏰑􏰌􏰏􏰐􏰆􏰄􏰊􏰌􏰇􏰝􏰀􏰀􏰑􏰌􏰏􏰐􏰆􏰄􏰊􏰌􏰇􏰀􏰌􏰑􏰀􏰒􏰆􏰏􏰅􏰌􏰐􏰆􏰄􏰌􏰗􏰒􏰀􏰘􏰉􏰒􏰊􏰌􏰇􏰒􏰀􏰙􏰐􏰆􏰊􏰇􏰘􏰓􏰀􏰌􏰒􏰄􏰉􏰌􏰒􏰆􏰏􏰅􏰌􏰐􏰆􏰒􏰀􏰆􏰇􏰋􏰀􏰑􏰊􏰈􏰏􏰌􏰒􏰆􏰏􏰅􏰌􏰐􏰆􏰒􏰚􏰞􏰀􏰀 􏰖􏰉􏰒􏰗􏰘􏰄􏰒􏰀􏰊􏰇􏰀􏰅􏰎􏰏􏰌􏰇􏰊􏰅􏰀􏰙􏰔􏰏􏰆􏰇􏰗􏰘􏰌􏰐􏰆􏰄􏰌􏰗􏰒􏰚􏰀􏰉􏰒􏰌􏰍􏰎􏰆􏰔􏰊􏰄􏰊􏰒􏰀􏰙􏰛􏰚􏰀􏰜􏰎􏰊􏰅􏰎􏰀􏰌􏰅􏰅􏰆􏰒􏰊􏰌􏰇􏰆􏰘􏰘􏰓􏰀􏰘􏰉􏰆􏰋􏰀􏰄􏰌􏰀􏰇􏰉􏰌􏰍􏰘􏰆􏰒􏰄􏰊􏰅􏰀 􏰄􏰏􏰆􏰇􏰒􏰑􏰌􏰏􏰐􏰆􏰄􏰊􏰌􏰇􏰝􏰀􏰀􏰑􏰌􏰏􏰐􏰆􏰄􏰊􏰌􏰇􏰀􏰌􏰑􏰀􏰒􏰆􏰏􏰅􏰌􏰐􏰆􏰄􏰌􏰗􏰒􏰀􏰘􏰉􏰒􏰊􏰌􏰇􏰒􏰀􏰙􏰐􏰆􏰊􏰇􏰘􏰓􏰀􏰌􏰒􏰄􏰉􏰌􏰒􏰆􏰏􏰅􏰌􏰐􏰆􏰒􏰀􏰆􏰇􏰋􏰀􏰑􏰊􏰈􏰏􏰌􏰒􏰆􏰏􏰅􏰌􏰐􏰆􏰒􏰚􏰞􏰀􏰀 􏰖􏰉􏰒􏰗􏰘􏰄􏰒􏰀􏰊􏰇􏰀􏰅􏰎􏰏􏰌􏰇􏰊􏰅􏰀􏰙􏰔􏰏􏰆􏰇􏰗􏰘􏰌􏰐􏰆􏰄􏰌􏰗􏰒􏰚􏰀􏰉􏰒􏰌􏰍􏰎􏰆􏰔􏰊􏰄􏰊􏰒􏰀􏰙􏰛􏰚􏰀􏰜􏰎􏰊􏰅􏰎􏰀􏰌􏰅􏰅􏰆􏰒􏰊􏰌􏰇􏰆􏰘􏰘􏰓􏰀􏰘􏰉􏰆􏰋􏰀􏰄􏰌􏰀􏰇􏰉􏰌􏰍􏰘􏰆􏰒􏰄􏰊􏰅􏰀 􏰄􏰏􏰆􏰇􏰒􏰑􏰌􏰏􏰐􏰆􏰄􏰊􏰌􏰇􏰝􏰀􏰀􏰑􏰌􏰏􏰐􏰆􏰄􏰊􏰌􏰇􏰀􏰌􏰑􏰀􏰒􏰆􏰏􏰅􏰌􏰐􏰆􏰄􏰌􏰗􏰒􏰀􏰘􏰉􏰒􏰊􏰌􏰇􏰒􏰀􏰙􏰐􏰆􏰊􏰇􏰘􏰓􏰀􏰌􏰒􏰄􏰉􏰌􏰒􏰆􏰏􏰅􏰌􏰐􏰆􏰒􏰀􏰆􏰇􏰋􏰀􏰑􏰊􏰈􏰏􏰌􏰒􏰆􏰏􏰅􏰌􏰐􏰆􏰒􏰚􏰞􏰀􏰀 : Spirocerca lupi in dogs 􏰖􏰉􏰒􏰗􏰘􏰄􏰒􏰀􏰊􏰇􏰀􏰅􏰎􏰏􏰌􏰇􏰊􏰅􏰀􏰙􏰔􏰏􏰆􏰇􏰗􏰘􏰌􏰐􏰆􏰄􏰌􏰗􏰒􏰚􏰀􏰉􏰒􏰌􏰍􏰎􏰆􏰔􏰊􏰄􏰊􏰒􏰀􏰙􏰛􏰚􏰀􏰜􏰎􏰊􏰅􏰎􏰀􏰌􏰅􏰅􏰆􏰒􏰊􏰌􏰇􏰆􏰘􏰘􏰓􏰀􏰘􏰉􏰆􏰋􏰀􏰄􏰌􏰀􏰇􏰉􏰌􏰍􏰘􏰆􏰒􏰄􏰊􏰅􏰀 􏰄􏰏􏰆􏰇􏰒􏰑􏰌􏰏􏰐􏰆􏰄􏰊􏰌􏰇􏰝􏰀􏰀􏰑􏰌􏰏􏰐􏰆􏰄􏰊􏰌􏰇􏰀􏰌􏰑􏰀􏰒􏰆􏰏􏰅􏰌􏰐􏰆􏰄􏰌􏰗􏰒􏰀􏰘􏰉􏰒􏰊􏰌􏰇􏰒􏰀􏰙􏰐􏰆􏰊􏰇􏰘􏰓􏰀􏰌􏰒􏰄􏰉􏰌􏰒􏰆􏰏􏰅􏰌􏰐􏰆􏰒􏰀􏰆􏰇􏰋􏰀􏰑􏰊􏰈􏰏􏰌􏰒􏰆􏰏􏰅􏰌􏰐􏰆􏰒􏰚􏰞􏰀􏰀
56
Esophageal Osteosarcoma- 􏰩􏰒􏰌􏰍􏰎􏰆􏰔􏰉􏰆􏰘􏰀􏰪􏰒􏰄􏰉􏰌􏰒􏰆􏰏􏰅􏰌􏰐􏰆􏰀􏰨􏰀S. lupi
57
􏰖􏰗􏰐􏰊􏰇􏰆􏰘􏰀􏰄􏰓􏰐􏰍􏰆􏰇􏰓􏰀􏰌􏰏􏰀􏰈􏰘􏰌􏰆􏰄􏰝􏰀􏰬􏰪􏰕􏰉􏰏􏰭 􏰋􏰊􏰒􏰄􏰉􏰇􏰄􏰊􏰌􏰇􏰀􏰌􏰑􏰀􏰄􏰎􏰉􏰀􏰏􏰗􏰐􏰉􏰇􏰀􏰆􏰇􏰋􏰀􏰏􏰉􏰄􏰊􏰅􏰗􏰘􏰗􏰐􏰀 􏰈􏰓􏰀􏰔􏰆􏰒􏰉􏰒􏰀􏰍􏰏􏰌􏰋􏰗􏰅􏰉􏰋􏰀􏰋􏰗􏰏􏰊􏰇􏰔􏰀 􏰑􏰉􏰏􏰐􏰉􏰇􏰄􏰆􏰄􏰊􏰌􏰇􏰮􏰯􏰆􏰗􏰒􏰉􏰋􏰀􏰈􏰓􏰀􏰍􏰎􏰓􏰒􏰊􏰅􏰆􏰘􏰀􏰌􏰏􏰀 􏰑􏰗􏰇􏰅􏰄􏰊􏰌􏰇􏰆􏰘􏰀􏰌􏰈􏰒􏰄􏰏􏰗􏰅􏰄􏰊􏰌􏰇􏰀􏰌􏰑􏰀􏰄􏰎􏰉􏰀􏰉􏰒􏰌􏰍􏰎􏰆􏰔􏰗􏰒􏰀 􏰏􏰉􏰒􏰗􏰘􏰄􏰊􏰇􏰔􏰀􏰊􏰇􏰀􏰑􏰆􏰊􏰘􏰗􏰏􏰉􏰀􏰄􏰌􏰀􏰉􏰏􏰗􏰅􏰄􏰆􏰄􏰉􏰀􏰙􏰉􏰞􏰔􏰞􏰝􏰀􏰕􏰆􏰔􏰗􏰒􏰀 􏰊􏰇􏰋􏰊􏰔􏰉􏰒􏰄􏰊􏰌􏰇􏰣􏰀􏰉􏰒􏰌􏰍􏰎􏰆􏰔􏰉􏰆􏰘􏰀􏰍􏰆􏰍􏰊􏰘􏰘􏰌􏰐􏰆􏰒􏰣􏰀 􏰘􏰓􏰐􏰍􏰎􏰌􏰒􏰆􏰏􏰅􏰌􏰐􏰆􏰀Ruminal tympany or bloat- over distention of the rumen and reticulum by gases produced by fermentation A. primary- often associated with new diets that promote the formation of stable foam B. Secondary- caused by physical or functional obstruction of the esophagus resulting in failure to eructate
58
Bloat, cow-AVC
59
“Bloat line” – the most reliable post-mortem indicator of ante-mortem bloat -, cow, Atlantic Veterinary College, AVC. blue=blood congestion
60
Foreign bodies Traumatic reticulitis -cattle
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􏰯􏰎􏰏􏰌􏰇􏰊􏰅􏰀􏰍􏰉􏰏􏰊􏰅􏰆􏰏􏰋􏰊􏰄􏰊􏰒􏰀􏰆􏰇􏰋􏰀􏰉􏰍􏰊􏰅􏰆􏰏􏰋􏰊􏰄􏰊􏰒􏰀􏰊􏰒􏰀􏰇􏰌􏰄􏰀􏰆􏰇􏰀􏰗􏰇􏰗􏰒􏰗􏰆􏰘􏰀􏰅􏰌􏰐􏰍􏰘􏰊􏰅􏰆􏰄􏰊􏰌􏰇􏰵􏰀 􏰯􏰎􏰏􏰌􏰇􏰊􏰅􏰀􏰍􏰉􏰏􏰊􏰅􏰆􏰏􏰋􏰊􏰄􏰊􏰒􏰀􏰆􏰇􏰋􏰀􏰉􏰍􏰊􏰅􏰆􏰏􏰋􏰊􏰄􏰊􏰒􏰀􏰊􏰒􏰀􏰇􏰌􏰄􏰀􏰆􏰇􏰀􏰗􏰇􏰗􏰒􏰗􏰆􏰘􏰀􏰅􏰌􏰐􏰍􏰘􏰊􏰅􏰆􏰄􏰊􏰌􏰇􏰵chronic pericarditis and epicarditis is not an unsual complication; go through diaphram and into the heart
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chemical rumenitis (lactic acidosis, grain overload) cattle
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“stellate ulcers” (ruminal scars) healing by fibrosis tissue from inflammation; from lactic acidosis
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6-month-old heifer, history of grain overload. AVC-1998
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Gastric dilation-volvulus (life-threatening condition)
􏰃􏰇􏰀􏰒􏰌􏰜􏰒􏰀􏰔􏰆􏰒􏰄􏰏􏰊􏰅􏰀􏰕􏰌􏰘􏰕􏰗􏰘􏰗􏰒􏰀􏰊􏰒􏰀􏰗􏰒􏰗􏰆􏰘􏰘􏰓􏰀􏰀 􏰒􏰉􏰉􏰇􏰀􏰆􏰑􏰄􏰉􏰏􏰀􏰬􏰉􏰶􏰅􏰉􏰒􏰒􏰊􏰕􏰉􏰀􏰊􏰇􏰄􏰆􏰷􏰉􏰀􏰌􏰑􏰀􏰀 􏰑􏰌􏰌􏰋􏰀􏰆􏰇􏰋􏰀􏰜􏰆􏰄􏰉􏰏􏰀􏰑􏰌􏰘􏰘􏰌􏰜􏰉􏰋􏰀􏰈􏰓􏰀􏰍􏰎􏰓􏰒􏰊􏰅􏰆􏰘􏰀􏰀 􏰆􏰅􏰄􏰊􏰕􏰊􏰄􏰓􏰀􏰊􏰇􏰀􏰆􏰀􏰅􏰌􏰐􏰍􏰉􏰄􏰊􏰄􏰊􏰕􏰉􏰀􏰔􏰏􏰌􏰗􏰍􏰀􏰀 􏰒􏰊􏰄􏰗􏰆􏰄􏰊􏰌􏰇􏰮􏰀 Most common in large, deep-chested breeds of dogs; also in sows
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Gastric dilatation-volvulus, dog
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Dog, gastric dilatation, volvulus –Intraluminal hemorrhage, Rhodesian ridgeback dog, AVC-97
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Abomasal displacement
􏰁 Occurs most often in post-parturient dairy cows and calves 􏰁 Left-sided is most common: generally non-fatal 􏰸 partial obstruction of abomasal flow 􏰁 Right-sided: Represent ~15% of the abomasal displacement. 20% of these result in abomasal volvulus. 􏰁 Abomasal displacements (left-sided or right-sided) lead to abdominal pain, elevated heart rate, anorexia, dehydration, depressed peristalsis with lack of feces and abomasal tympany (high-pitch ping elicited by percussion).
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Gastric rupture􏰣􏰀􏰎􏰌􏰏􏰒􏰉􏰀􏰨􏰀􏰯􏰌􏰏􏰇􏰉􏰘􏰘􏰀􏰑􏰊􏰘􏰉􏰒􏰀 􏰢􏰌􏰒􏰄􏰀􏰅􏰆􏰒􏰉􏰒􏰀􏰌􏰑􏰀􏰔􏰆􏰒􏰄􏰏􏰊􏰅􏰀􏰏􏰗􏰍􏰄􏰗􏰏􏰉􏰀􏰊􏰇􏰀􏰎􏰌􏰏􏰒􏰉􏰒􏰀􏰆􏰏􏰉􏰀􏰋􏰗􏰉􏰀􏰄􏰌􏰀􏰊􏰇􏰄􏰉􏰒􏰄􏰊􏰇􏰆􏰘􏰀􏰌􏰈􏰒􏰄􏰏􏰗􏰅􏰄􏰊􏰌􏰇􏰒􏰀 􏰙􏰊􏰘􏰉􏰗􏰒􏰚􏰀􏰸􏰀􏰆􏰋􏰓􏰇􏰆􏰐􏰊􏰅􏰀􏰙􏰍􏰆􏰏􏰆􏰘􏰓􏰄􏰊􏰅􏰚􏰀􏰌􏰏􏰀􏰐􏰉􏰅􏰎􏰆􏰇􏰊􏰅􏰆􏰘􏰀􏰊􏰘􏰉􏰗􏰒􏰞􏰀􏰛􏰋􏰓􏰇􏰆􏰐􏰊􏰅􏰀􏰊􏰘􏰉􏰗􏰒􏰀􏰏􏰉􏰒􏰗􏰘􏰄􏰒􏰀 􏰑􏰏􏰌􏰐􏰀􏰊􏰇􏰎􏰊􏰈􏰊􏰄􏰊􏰌􏰇􏰀􏰌􏰑􏰀􏰈􏰌􏰜􏰉􏰘􏰀􏰐􏰌􏰄􏰊􏰘􏰊􏰄􏰓􏰀􏰐􏰌􏰏􏰉􏰀􏰅􏰌􏰐􏰐􏰌􏰇􏰘􏰓􏰀􏰅􏰆􏰗􏰒􏰉􏰋􏰀􏰈􏰓􏰀􏰍􏰉􏰏􏰊􏰄􏰌􏰇􏰊􏰄 􏰢􏰌􏰒􏰄􏰀􏰅􏰆􏰒􏰉􏰒􏰀􏰌􏰑􏰀􏰔􏰆􏰒􏰄􏰏􏰊􏰅􏰀􏰏􏰗􏰍􏰄􏰗􏰏􏰉􏰀􏰊􏰇􏰀􏰎􏰌􏰏􏰒􏰉􏰒􏰀􏰆􏰏􏰉􏰀􏰋􏰗􏰉􏰀􏰄􏰌􏰀􏰊􏰇􏰄􏰉􏰒􏰄􏰊􏰇􏰆􏰘􏰀􏰌􏰈􏰒􏰄􏰏􏰗􏰅􏰄􏰊􏰌􏰇􏰒􏰀 􏰙􏰊􏰘􏰉􏰗􏰒􏰚􏰀􏰸􏰀􏰆􏰋􏰓􏰇􏰆􏰐􏰊􏰅􏰀􏰙􏰍􏰆􏰏􏰆􏰘􏰓􏰄􏰊􏰅􏰚􏰀􏰌􏰏􏰀􏰐􏰉􏰅􏰎􏰆􏰇􏰊􏰅􏰆􏰘􏰀􏰊􏰘􏰉􏰗􏰒􏰞􏰀􏰛􏰋􏰓􏰇􏰆􏰐􏰊􏰅􏰀􏰊􏰘􏰉􏰗􏰒􏰀􏰏􏰉􏰒􏰗􏰘􏰄􏰒􏰀 􏰑􏰏􏰌􏰐􏰀􏰊􏰇􏰎􏰊􏰈􏰊􏰄􏰊􏰌􏰇􏰀􏰌􏰑􏰀􏰈􏰌􏰜􏰉􏰘􏰀􏰐􏰌􏰄􏰊􏰘􏰊􏰄􏰓􏰀􏰐􏰌􏰏􏰉􏰀􏰅􏰌􏰐􏰐􏰌􏰇􏰘􏰓􏰀􏰅􏰆􏰗􏰒􏰉􏰋􏰀􏰈􏰓􏰀􏰍􏰉􏰏􏰊􏰄􏰌􏰇􏰊􏰄􏰊Most cases of gastric rupture in horeses are due to intestinal obstructions ileus; adynamic or mechincal ileus. Adynamic ileus results from inhibition of bowl motility more commonly caused by perinonitis Since horses can't vomit they get gastric ruptures secondary to gastric obstructions
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Horse, chronic diaphragmatic hernia leading to gastric rupture and Death. UCVM-2008.
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What is common to cause gastric impaction/rupture in horses?
Persimmons
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Gastric ulcer, pig 􏰠􏰉􏰉􏰇􏰀􏰊􏰇􏰀􏰍􏰊􏰔􏰒􏰀􏰑􏰉􏰋􏰀􏰑􏰊􏰇􏰉􏰘􏰓􏰀􏰔􏰏􏰌􏰗􏰇􏰋􏰀􏰏􏰆􏰄􏰊􏰌􏰇􏰒􏰞􏰀􏰻􏰊􏰔􏰎􏰀 􏰜􏰎􏰉􏰆􏰄􏰀􏰅􏰌􏰐􏰍􏰌􏰇􏰉􏰇􏰄􏰀􏰊􏰇􏰀􏰄􏰎􏰉􏰀􏰑􏰉􏰉􏰋􏰀􏰆􏰘􏰒􏰌􏰀􏰍􏰘􏰆􏰓􏰒􏰀􏰆􏰀 􏰏􏰌􏰘􏰉􏰞Seen in pigs fed finely ground rations- melana gastric bleeding
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What are possible causes?
Pig, gastric ulcer Possible causes- finely ground feed, high copper, high starch and low protein diets, unsaturated fatty acids, hisatmine, stress Pigs and horses- main complication- perferating ulcers
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MDx and cause
MDx: multi-focal necrotizing ulcerative gastritis Cause- NSAIDS squamous is the esphagus white=keratin
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gastric ulceration; NSAIDS, horse Causes ischemic necrosis NSAID in equines- stomach and meduallary papilla of kidney
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􏰢􏰌􏰒􏰄􏰀􏰔􏰆􏰒􏰄􏰏􏰊􏰅􏰀􏰗􏰘􏰅􏰉􏰏􏰒􏰀􏰊􏰇􏰀􏰅􏰆􏰄􏰒􏰀􏰆􏰇􏰋􏰀􏰀gastric ulcers in cats and dogs are idiopathic. Cutanous mast-cell tumors in dogs may lead to gastric ulceration. Gastric ulcers: 1. increased NSAID or seteriodal 2. increased histamine levels ass with mast cell tumors or mastocytosis 3. gastrin-secreting pancreatic islet cell tumors or gastrinomas 􏰋􏰌􏰔􏰒􏰀􏰆􏰏􏰉􏰀􏰊􏰋􏰊􏰌􏰍􏰆􏰄􏰎􏰊􏰅􏰞􏰀
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Right: Perforated gastro- duodenal ulcer in a dog with a mast cell tumor. Noah’s Arkives, UGA. May occur in dogs with solitary cutaneous mast cell tumors.
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Stomach, pig –thrombosis & hemorrhage (gastric venous infarction) secondary to endotoxemia or bacterial sepsis. Occasionally seen in ruminants and horses Et: e. coli or salmonella in pigs- e. rushtophatie, glasser's disease
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Uremic gastropathy (uremic gastritis, cat).
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􏰟􏰏􏰉􏰐􏰊􏰅􏰀􏰔􏰆􏰒􏰄􏰏􏰊􏰄􏰊􏰒􏰣􏰀􏰤􏰀􏰓􏰉􏰆􏰏􏰭􏰌􏰘􏰋􏰀􏰀 􏰠􏰎􏰊􏰭􏰲􏰼􏰗􏰀􏰋􏰌􏰔􏰀􏰜􏰊􏰄􏰎􏰀􏰑􏰆􏰐􏰊􏰘􏰊􏰆􏰘􏰀􏰏􏰉􏰇􏰆􏰘􏰀 􏰋􏰊􏰒􏰉􏰆􏰒􏰉􏰣􏰀􏰛􏰡􏰯􏰞􏰀􏰖􏰊􏰔􏰎􏰄􏰝􏰀􏰡􏰌􏰇􏰭􏰀􏰽􏰌􏰒􏰒􏰆􏰀 􏰒􏰄􏰆􏰊􏰇􏰀􏰋􏰉􏰐􏰌􏰇􏰒􏰄􏰏􏰆􏰄􏰊􏰇􏰔􏰀􏰜􏰊􏰋􏰉􏰒􏰍􏰏􏰉􏰆􏰋􏰀 􏰔􏰆􏰒􏰄􏰏􏰊􏰅􏰀􏰐􏰊􏰇􏰉􏰏􏰆􏰘􏰊􏰼􏰆􏰄􏰊􏰌􏰇􏰞􏰀 Uremic gastritis; 2 year old shi-tzu with familiar renal disease; Von-Kossa stain CHF causes other locations- uremic gastritis, stomattis, left ventricular mural myocarditis, pneumonitis, thrombosis
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Abomasitis lamb, brazy, 􏰛􏰈􏰌􏰐􏰆􏰒􏰊􏰄􏰊􏰒􏰣􏰀􏰘􏰆􏰐􏰈􏰀􏰨􏰀􏰰􏰏􏰆􏰶􏰓􏰀􏰙􏰈􏰏􏰆􏰋􏰒􏰌􏰄􏰚􏰣􏰀Clostridium septicum􏰣􏰀􏰀 􏰯􏰌􏰏􏰇􏰉􏰘􏰘􏰀􏰑􏰊􏰘􏰉􏰒􏰞􏰀􏰀 causes of death is endotoxemia
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􏰛Abomastitis, necro-hemorrhagic with submucosal emphysema, Braxy 􏰈􏰌􏰐􏰆􏰒􏰊􏰄􏰊􏰒􏰣􏰀􏰇􏰉􏰅􏰏􏰌􏰭􏰎􏰉􏰐􏰌􏰏􏰏􏰎􏰆􏰔􏰊􏰅􏰀􏰜􏰊􏰄􏰎􏰀􏰒􏰗􏰈􏰐􏰗􏰅􏰌􏰒􏰆􏰘􏰀􏰉􏰐􏰍􏰎􏰓􏰒􏰉􏰐􏰆􏰣􏰀􏰘􏰆􏰐􏰈􏰣􏰀􏰀 􏰰􏰏􏰆􏰶􏰓􏰀􏰙􏰈􏰏􏰆􏰋􏰒􏰌􏰄􏰚􏰣􏰀Clostridium septicum􏰣􏰀􏰯􏰌􏰏􏰇􏰉􏰘􏰘􏰀􏰑􏰊􏰘􏰉􏰒􏰞􏰀􏰃􏰄􏰀􏰐􏰆􏰓􏰀􏰆􏰘􏰒􏰌􏰀􏰆􏰑􏰑􏰉􏰅􏰄􏰀
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Mycotic abomasitis- often a sequel of long-term antibiotic therapy which destroys resident bacterial flora and promotes the growth of angio-invasive fungi such as􏰀􏰔􏰌􏰆􏰄􏰭􏰀􏰯􏰌􏰏􏰇􏰉􏰘􏰘􏰀􏰑􏰊􏰘􏰉􏰒􏰞􏰀 􏰢􏰓􏰅􏰌􏰄􏰊􏰅􏰀􏰆􏰈􏰌􏰐􏰆􏰒􏰊􏰄􏰊􏰒􏰀􏰊􏰒􏰀􏰌􏰑􏰄􏰉􏰇􏰀􏰆􏰀􏰒􏰉􏰾􏰗􏰉􏰘􏰀􏰌􏰑􏰀􏰘􏰌􏰇􏰔􏰭􏰄􏰉􏰏􏰐􏰀􏰆􏰇􏰄􏰊􏰈􏰊􏰌􏰄􏰊􏰅􏰀􏰄􏰎􏰉􏰏􏰆􏰍􏰓􏰀􏰜􏰎􏰊􏰅􏰎􏰀􏰋􏰉􏰒􏰄􏰏􏰌􏰓􏰒􏰀􏰏􏰉􏰒􏰊􏰋􏰉􏰇􏰄􏰀 􏰈􏰆􏰅􏰄􏰉􏰏􏰊􏰆􏰘􏰀􏰑􏰘􏰌􏰏􏰆􏰀􏰆􏰇􏰋􏰀􏰍􏰏􏰌􏰐􏰌􏰄􏰉􏰒􏰀􏰄􏰎􏰉􏰀􏰔􏰏􏰌􏰜􏰄􏰎􏰀􏰌􏰑􏰀􏰆􏰇􏰔􏰊􏰌􏰭􏰊􏰇􏰕􏰆􏰒􏰊􏰕􏰉􏰀􏰑􏰗􏰇􏰔􏰊􏰀􏰒􏰗􏰅􏰎􏰀􏰆􏰒􏰀Aspergillus, Absidia, Rhizopus, Mucor spp. 􏰉􏰄􏰅􏰞􏰀􏰠􏰉􏰍􏰒􏰊􏰒􏰀􏰆􏰇􏰋􏰀􏰌􏰄􏰎􏰉􏰏􏰀􏰋􏰉􏰈􏰊􏰘􏰊􏰄􏰆􏰄􏰊􏰇􏰔􏰀􏰅􏰌􏰇􏰋􏰊􏰄􏰊􏰌􏰇􏰒􏰀􏰆􏰏􏰉􏰀􏰆􏰘􏰒􏰌􏰀􏰍􏰏􏰉􏰋􏰊􏰒􏰍􏰌􏰒􏰊􏰇􏰔􏰀􏰑􏰆􏰅􏰄􏰌􏰏􏰒􏰞􏰀 . sepsis and other debilitating conditions are also predisposing factors MDX: necro-hemorragic abomastits
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Mycotic abomasitis, calf-
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􏰢􏰓􏰅􏰌􏰄􏰊􏰅􏰀􏰕􏰆􏰒􏰅􏰗􏰘􏰊􏰄􏰊􏰒􏰺􏰀􏰍􏰉􏰏􏰊􏰕􏰆􏰒􏰅􏰗􏰘􏰊􏰄􏰊􏰒􏰣􏰀􏰋􏰌􏰔 Mycotic vasculitis/perivascultis dogs with silver stain
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Gasterophilus nasalis and intestinalis, horse
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Erosive-ulcerative lesions caused by Gasterophilus intestinalis, horse
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Abomasal folds. Proliferative (hyperplastic) abomasitis due to Ostertagia spp. “Moroccan leather” appearance of the affected abomasal mucosa.
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Draschia megastoma (spirurid nematode) -brood pouch close to the margo plicatus (mucosal/submucosal nodule). Granulomatous gastritis, horse.
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Haemonchus contortus􏰀􏰊􏰒􏰀􏰆􏰀􏰄􏰏􏰊􏰅􏰎􏰌􏰒􏰄􏰏􏰌􏰇􏰔􏰓􏰘􏰊􏰋􏰀􏰇􏰉􏰐􏰆􏰄􏰌􏰋􏰉􏰀􏰍􏰆􏰏􏰆􏰒􏰊􏰄􏰉􏰀􏰄􏰎􏰆􏰄􏰀􏰅􏰆􏰗􏰒􏰉􏰒􏰀 􏰋􏰊􏰒􏰉􏰆􏰒􏰉􏰀􏰍􏰏􏰊􏰐􏰆􏰏􏰊􏰘􏰓􏰀􏰊􏰇􏰀􏰒􏰎􏰉􏰉􏰍􏰀􏰆􏰇􏰋􏰀􏰔􏰌􏰆􏰄􏰒􏰞􏰀􏱀􏰆􏰏􏰆􏰒􏰊􏰄􏰊􏰅􏰀􏰆􏰈􏰌􏰐􏰆􏰒􏰊􏰄􏰊􏰒􏰀􏰘􏰉􏰆􏰋􏰒􏰀􏰄􏰌􏰀􏰈􏰘􏰌􏰌􏰋􏰣􏰀 􏰘􏰌􏰒􏰒􏰣􏰀􏰆􏰇􏰉􏰐􏰊􏰆􏰀􏰆􏰇􏰋􏰀􏰎􏰓􏰍􏰌􏰍􏰏􏰌􏰄􏰉􏰊􏰇􏰉􏰐􏰊􏰆􏰞 is a tristrongylid nematode parasite that causes disease primarily in sheep and goats. Parasitic abomastitis leasds to blood loss, anemia, and hypoproteinemia.
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􏱀􏰆􏰏􏰆􏰒􏰊􏰄􏰊􏰅􏰀􏰆􏰈􏰌􏰐􏰆􏰒􏰊􏰄􏰊􏰒􏰣􏰀􏰒􏰎􏰉􏰉􏰍􏰀􏰸􏰀􏰰􏰘􏰌􏰌􏰋􏰭􏰒􏰗􏰅􏰷􏰊􏰇􏰔􏰀􏰄􏰏􏰊􏰅􏰎􏰌􏰒􏰄􏰏􏰌􏰇􏰔􏰓􏰘􏰊􏰋􏰀􏰍􏰆􏰏􏰆􏰒􏰊􏰄􏰉􏰀􏰭􏱁􏰀􏰅􏰆􏰇􏰀􏰀 􏰆􏰘􏰒􏰌􏰀􏰆􏰑􏰑􏰉􏰅􏰄􏰀􏰔􏰌􏰆􏰄􏰒􏰀􏰆􏰇􏰋􏰀􏰅􏰆􏰄􏰄􏰘􏰉􏰞􏰀 Parasitic abomastitis, sheep- blood-suckign trichostronglyid parasite, can also affect goats and cattle Lesion itself- superficial erosive gastritis EDx: parsitic gastritis "barber pole worm"
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􏰹􏰆􏰒􏰄􏰏􏰊􏰅􏰀􏰒􏰾􏰗􏰆􏰐􏰌􏰗􏰒􏰀􏰅􏰉􏰘􏰘􏰀􏰅􏰆􏰏􏰅􏰊􏰇􏰌􏰐􏰆􏰣􏰀􏰎􏰌􏰏􏰒􏰉􏰀 SCC
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Horse, gastric squamous cell carcinoma most common in horses; mechanical obstruction- can't eat
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Peritoneal carcinomatosis. Horse, Gastric Squamous Cell Carcinoma, Noah’sArkives
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Gastric lymphosarcoma, horse
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􏱂􏰠􏰛􏰣􏰀􏰆􏰈􏰌􏰐􏰆􏰒􏰗􏰐􏰀􏰨􏰅􏰌􏰜􏰣􏰀􏰛􏰡􏰯􏰞􏰀 LSA abomasum, cow
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􏰢􏰗􏰘􏰄􏰊􏰅􏰉􏰇􏰄􏰏􏰊􏰅􏰀􏰘􏰓􏰐􏰍􏰎􏰌􏰒􏰆􏰏􏰅􏰌􏰐􏰆􏰣􏰀􏰆􏰈􏰌􏰐􏰆􏰒􏰆􏰘􏰀􏰊􏰇􏰕􏰌􏰘􏰕􏰉􏰐􏰉􏰇􏰄􏰀􏰜􏰊􏰄􏰎􏰀􏰗􏰘􏰅􏰉􏰏􏰆􏰄􏰊􏰌􏰇􏰀􏰀 􏰪􏰑􏰀􏰆􏰈􏰌􏰐􏰆􏰒􏰆􏰘􏰀􏰑􏰌􏰘􏰋􏰒􏰣􏰀􏰅􏰌􏰜􏰣􏰀􏰟􏰯􏰡􏰢􏰣􏰀􏰰􏰦􏰴􏰭􏰤􏰥􏰦􏰥􏰀 Multi-centric Lymphoma
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What is the most common segmental anomaly of the intestine?
Atresisa coli
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Segmental anomalies in the intestine are relatively common and can range from stenosis (incomplete occlusion of the intestinal lumen) to atresia (complete occlusion/ obliteration of the intestinal lumen). Ischemia of a segment of gut during fetal development? It may be an autosomal recessive trait in Holstein calves.
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Diagnosis: Atresia ani (imperforate anus) with concomitant recto-vaginal fistula – Right: Note prominent megacolon
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Lethal white syndrome in foals
(congenital colonic aganglionosis – an autosomal recessive genetic disorder) Most prevalent in the American Paint Horse. Usually (but not all) horses with a white-spotting pattern are carriers of this trait (heterozygus).
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Microscopically there is absence of myenteric and submucosal parasympathetic ganglia in the wall of the ileum, cecum and colon leading to intestinal immotility and colic (colonic or ileocolonic aganglionosis). Lethal white syndrom in foals
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Enterolith, horse - Composed of concentric lamellae of magnesium, ammonium phosphate (struvite) deposit around a “nucleus” foreign body such as a nail, wire etc. Vary in size, some may weight up to 10 kg. Acquired obstructions
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Trichobezoars
(hairballs) – cattle, Pathology Museum, Faculty ofVeterinary Science, University of Liverpool. Are not as heavy as enteroliths (located in the forestomach and abomasum) . Also found in dogs and cats.
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Phytobezoars
Phytobezoars or phytotrichobezoarscomposed mainly of plant material impregnated with Some phosphate salts may be found in the colon of horses.
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Ascarids impaction, foal more of a mechanical problem than a damage problem
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Rectal stricture – Pig, chronic salmonellosis, (Salmonella typhimurium) Noah’s Arkives Penetrating wounds (foreign bodies etc..) can also lead to stricture and stenosis within the GI tract.
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Hernia:
The protrusion of an organ or part of an organ/tissue through an abnormal opening
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Internal vs external hernia
 Internal hernia: Displacement of intestine through a normal or abnormal foramina within the abdominal cavity (rare). Examples: incarceration (entrapment) of loops of the intestine within the slit-like epiploic foramen, or a rent (tear) in the omentum or mesentery.  External hernia VERY COMMON: Displacement of loops of intestine, omentum and occasionally other viscera (hernial contents) outside the abdominal cavity. Displaced contents are inside of a pouch (hernial sac, formed by the peritoneum and the skin) which protrudes through the hernial ring - an opening in the abdominal wall which could be acquired or natural (e.g.: vaginal ring of the inguinal canal).  If the displaced abdominal contents are not covered by parietal peritoneum or skin the lesion is referred to as “eventration”.
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Mare. Eventration of the cecum secondary to trauma,
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Mare. Eventration of the cecum secondary to trauma
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Cat, diaphragmatic hernia due to trauma. It can also be congenital. Herniation of the liver and loops of the small intestine are more common. Intestine in the thoraic cavity- happens after trauma i.e. HBC
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Scrotal (inguinal) hernia - pig
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Scrotal hernia, pig,
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Incarceration of a piece of small intestinelead to venous infarction, sepsis, and death. Scrotal hernia, pig,
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Umbilical hernia, pig, AVC
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Strangulated loop of small intestine – umbilical hernia, pig, AVC
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Torsion of the left colon -horse
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Colonic torsion-horse
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Intestinal volvulus - horse
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Herniation of small intestine through the epiploic foramen (internal hernia) – horse, Cornell files
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Intestinal strangulation by pedunculated lipomas.
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Pedunculated lipomas
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Intussusception
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Intestinal intussusception, foal, Texas A&M, JEdwards.
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Intestinal intussusception
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Horse presented with severe colic unresponsive to palliative treatment to control the pain. Euthanized. Atlantic Veterinary College
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Horse,cecocolonicintussusception,AVC
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Viral Enteritis BVD: Pestivirus, bison. Most cattle develop a relative mild or subclinical Form of the disease. MDx: ulcerative colitis The most severe form of the disease (Mucosal disease – low morbidity but high mortality) occurs most commonly in persistently infected animals which subsequently become infected with a closely related CP strain; or when the persistent virus develops specific mutations.Affected cattle are usually 6 months to 2 years of age.
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MCF Gamma herpesvirus (genus rhadinovirus)  Affects a variety of ruminants, including bison and cervids.  In America we have tHe “sheep-Associated MCF” observed in bovids and deer in contact with sheep. Fibrino-necrotizing vasculitis, with prominent lymphocytic perivascular infiltrates can be Found in several organs and tissues. NO CLINICAL SIGNS IN SHEEP
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Enteric coronaviral infections Common cause of neonatal diarrhoea in calves; alone or in combination with other agents like rotavirus or Cryptosporidium A&B: Transmissible gastro-enteritis (TGE) in piglets: Severe villous atrophy (blunting) and fusion. High mortality in young piglets. LYMPHOCYTES AND PLASMA CELLS - FIP in cats
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TGEV-Positive immunohistochemistry. Small intestine, piglet. Note severe villus blunting (villus attenuation/ atrophy). can see through intestine Cytokeratin- epithelial cells
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Enteric rotaviral infections
Enteric rotaviral infections  Rotavirus can cause diarrhoea in young animals of any species  also causes damage to surface enterocytes resulting in variable degrees of villous atrophy.  Subclinical infections are common in piglets.
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Parvovirus enteritis , puppy, Noah`s Arkives – CPV-2. In cats the disease is caused by feline panleucopenia virus –bone marrow lesions dominate the clinical picture CPV-2 Neuro-enterigic enterisits.
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Panleukopenia, cat, TAMU. Segmental fibrino-hemorrhagic enteritis.
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Parvovirus enteritis, puppy In older cats a similar necrotizing enteritis can be caused by FeLV infection.
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FIP
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Bacterial Enteritis E. coli
Important cause of enteritis in neonatal animals 􏱃 Bacterial strains have different virulence factors which result in different clinical syndromes 􏱃 Virulence factors promote colonization or adhesion, metabolic dysfunction or death of enterocytes, affect the local or systemic vasculature, or promote invasion and septicemia.
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Edema disease (enterotoxemic colibacillosis) in pigs. Most common in pigs a few weeks after weaning. Bacterial enterotoxin (verotoxin) that causes endothelial cell injury in arterioles resulting in fluid loss and edema. Affected animals may exhibit focal bilaterally symmetric encephalomalacia (``Cerebrospinal angiopathy of swine``).
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Cholstridial enterotoxemia
Caused by Clostridium perfringens group (type) A to E. Type D is most common. 􏱃 Affects the best nourished animals in the group. 􏱃 Animals may be found dead or may exhibit bloody diarrhea. 􏱃 C. perfringens type D produces an angiotoxin (epsilon toxin) which in addition to intestinal lesions causes focal symmetrical encephalomalacia (FSE) in sheep. You have to prove that the toxin is there, since the bacteria is normal in feces
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``` Clostridial enteritis (Necrotic enteritis) in a chicken, AVC. Necrotic villi are lined by Gram positive bacilli Clostridium perfringens type A. ```
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Tyzzer`s disease
Tyzzer`s disease (Clostridium piliforme) – Occurs in multiple species. The main target is the liver but lesions also occur in the intestine (port of entry) and the heart.
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Colitis X
Colitis X Typhlocolitis of horses: Probably the result of dysbacteriosis (often associated to antibiotic therapy or dietary changes) leading to proliferation of toxigenic clostridia, specially Clostridium perfringens type A and Clostridium difficile.
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Salmonellosis
􏱃 All Salmonella species are pathogenic 􏱃 Clinical disease ranges from a localized enterocolitis to septicemia 􏱃 Stress factors are important in the onset of clinical disease 􏱃 Zoonotic and nosocomial infection 􏱃 Acute enteric lesions are those of an ulcerative and fibrino- necrotizing enterocolitis. 􏱃 Intestinal contents are malodorous and contain mucus, fibrin and occasionally blood (feces: “septic tank odor”).
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Horse, colon: edema and hemorrhage: Salmonellosis, Cornell
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Fibrino-necrotizing entero-colitis, Horse, Salmonella, Cornell
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Horse, Embolic mycotic pneumonia – Sequel of Salmonellosis, Cornell
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Horse, Embolic mycotic pneumonia – Sequel of Salmonellosis, Cornell
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Pig, chronic salmonellosis, button ulcers, Cornell files fibrin rectal strictures- are other manifestations of chronic salmonellosis; lead to fecal retention, megacolon, etc
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Proliferative ileitis: Lawsonia intracellularis, Pig, Cornell files The disease, currently named as ``Porcine Proliferative Enteropathy`` (PPE), causes different syndromes.
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Necrotic enteritis: Lawsonia intracellularis, Pig. Cornell files
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Proliferative hemorrhagic enteropathy, L. intracellularis, pig, AVC. excessive crypts
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Proliferative ileitis, Lawsonia intracellularis , pig, W**arthin-Starry silver stain, AVC**
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Swine dysentery (spirochetal colitis ), caused by Brachyspira hyodysenteriae. The disease affects mainly pigs 8-14 weeks old and is characterized by large bowel diarrhea with mucous and blood in the feces.
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Swine dysentery, Brachyspira hyodysenteriae
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Rhodococcus equi
􏱃 Causes an enterocolitis in young horses 􏱃 Virulent factors allow the bacteria to survive within the cytoplasm of macrophages and cause chronic disease 􏱃 Typically R. Equi is associated with suppurative pyogranulomatous pneumonia in foals. 􏱃 The enteric lesions are ulcerative and pyogranulomatous and are associated with prominent regional lymphadenitis.
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Foal, pyogranulomatous colitis, Rhodococcus equi, Noah’s Arkives
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McGavin. Pyogranulomatous colic lymphadenitis, Rhodococcus equi
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Pyogranulomatous lymphadenitis, R. equi, foal. Noah’s
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Foal, 6-week-old, Rhodoccocus equi pneumonia, Cornell
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Mycobacterium avium, ssp. paratuberculosis Johne`s disease (paratuberculosis) – Chronic disease of ruminants. Clinical disease, characterized by diarrhea, emaciation and hypoproteinemia, usually occurs in animals older than 19 months.
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Granulomatous enteritis, Noah’s Archives
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Granulomatous enteritis, Noah’s Archives F03702, UGA, Bovine, Jejunum 􏰸 Lesions can be found in the ileum, cecum and proximal colon. Ileocecal valve is usually affected. lots of macrophages ileal/cecal junction
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Johne's disease
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Granulomatous lymphangitis with lymphangiectasia(when lymphnodess are grossly visible), Goat – Johne’s disease,
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Granulomatous Colitis in Boxer dogs (Histiocytic Ulcerative Colitis) F09903 –F09904 –WSU. 􏱅 The disease in Boxers appears to be associated with selective intramucosal colonization by specific strains of E. coli. 􏱅Similar findings have been reported in people with inflammatory bowel disease, particularly with Crohn’s disease.
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Calf, Cryptosporidiosis, HE, Noah’s Archives Diagnosis is made by the finding of numerous protozoal organisms attached to the apical surface of enterocytes.
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Coccidial enteritis A-D: Proliferative enteritis, goat kid, AVC.
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Top: Proliferative, hemorrhagic & necrotizing enteritis, Coccidiosis, calf. Noah’s Arkive
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Hookworms 􏱃 Dogs: Ancylostoma caninum & Uncinaria stenocephala 􏱃 Blood sucking parasites that may cause significant anemia and hypoproteinemia in puppies. 􏱃 Larvae may be found in the colostrum.
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Anaplocephala perfolita- hookworms in horses
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Trichuris (Whipworm) 􏱆 Trichuris spp. Parasitize the cecum and colon of domestic animals. 􏱆 Most infections are subclinical 􏱆 Severe infections may lead to bloody diarrhea, weight loss, dehydration and anemia.
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Left: Ascaris suum infection, Pig, AVC “Milk spotted liver”, pig, UCVM
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Lymphosarcoma (LSA) in a pig. The tumor ruptured and led to fatal peritonitis. AVC
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Neoplastic Diseases of the Intestine
􏱃 Intestinal tumors are most common in dogs and cats. 􏱃 Most primary tumors are carcinomas 􏱃 Lymphosarcomas may arise in the intestine but in most cases they are a manifestation of multicentric lymposarcoma. The exception may be the cat 􏱃 LSA is the most common neoplasm in cats and the “alimentary form” of lymphosarcoma has the highest incidence in this species.