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Long Case - Haematology > ALL and AML > Flashcards

Flashcards in ALL and AML Deck (6)
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1

ALL is?

Malignancy of B or T Lymphocytes causing proliferation of immature blast cells which cause marrow failure and tissue infiltration

genetic + environmental triggers
associated with Downs syndrome
Most common childhood cancer, very rare in adults

2

Signs and symptoms of ALL

MARROW FAILURE
= anaemia
= thrombocytopenia (bleeding)
= leukopenia (infection )
= hepatosplenomegaly (infiltration)
= lymphadenopathy
= CNS symptoms (meningism and nerver palsies)

3

Investigations for ALL

Blood film = blast cells
bone marrow = blast cells
FBC = raised WBC, low Hb and low Plt
CXR and CT = looking for lymphadenopathy

4

Management of ALL and Prognisis

Blood/platelet transfusion
allopurinol = prevents tumour lysis syndrome
febrile neutropenia = IV Abx
Chemotherapy
allogenic bone graft

Prognosis:
up to 90% cure rates in children (40% adults)

5

AML is?

Acute myeloid leukaemia is a rapidly progressive proliferation of myeloid cells - commonest leukaemia in adults and can be as a result of chemo and radiation

6

AML is the same as ___?

ALL

- same Signs, same Ix, same management