Flashcards in ALL and AML Deck (6)
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1
ALL is?
Malignancy of B or T Lymphocytes causing proliferation of immature blast cells which cause marrow failure and tissue infiltration
genetic + environmental triggers
associated with Downs syndrome
Most common childhood cancer, very rare in adults
2
Signs and symptoms of ALL
MARROW FAILURE
= anaemia
= thrombocytopenia (bleeding)
= leukopenia (infection )
= hepatosplenomegaly (infiltration)
= lymphadenopathy
= CNS symptoms (meningism and nerver palsies)
3
Investigations for ALL
Blood film = blast cells
bone marrow = blast cells
FBC = raised WBC, low Hb and low Plt
CXR and CT = looking for lymphadenopathy
4
Management of ALL and Prognisis
Blood/platelet transfusion
allopurinol = prevents tumour lysis syndrome
febrile neutropenia = IV Abx
Chemotherapy
allogenic bone graft
Prognosis:
up to 90% cure rates in children (40% adults)
5
AML is?
Acute myeloid leukaemia is a rapidly progressive proliferation of myeloid cells - commonest leukaemia in adults and can be as a result of chemo and radiation
6