Altered Thought Processes Flashcards

1
Q

what is psychosis

A

A syndrome of neurocognitive symptoms that impairs cognitive capacity,
leading to deficits of perception, functioning, and social relatedness

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2
Q

what are the 5 symptomatic domains of psychosis

A

Delusions
 Hallucinations
 Disorganized thought
 Disorganized or abnormal motor behavior
 Negative symptoms

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3
Q

what is primary psychosis

A

 A psychiatric cause, i.e. schizophrenia, schizoaffective DO
 Psychobiological origin (genetic & neural pathways) makes future episodes
more likely to occur

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4
Q

what is secondary psychosis

A

 Contributing cause, i.e. substance intoxication, delirium, or dementia
 Have a greater chance to recover

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5
Q

what can psychosis do

A

Unregulated neural circuits release inflammatory markers that degrade
the circuit
can cause dementia

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6
Q

is there a genetic link btwn scizophrenia

A

yes

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7
Q

neurobio of scizo

A

Dopamine hypothesis (associated
with positive symptoms)
* Increased dopamine production
* Increased release of dopamine
* Increased receptor sensitivity
* Increased dopamine receptors

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8
Q

other nts involved in scizo

A

norepinephrine, serotonin, acetylcholine, GABA, and glutamate, loss of grey matter, ventricular enlargement

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9
Q

excess or not enough serotonin in scizo

A

excess

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10
Q

what do glutamate levels do

A

Increase during stress
 First episode of psychosis
precipitated by stress
 Hippocampus becomes
hypermetabolic then atrophies
 Common finding in schizophrenia –
research to identify new biomarkers
to signal early illness, prevention, &
treatment

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11
Q

positive symptopns of scizo

A

overt symptoms that should not be present
hallucinations
delusions
disorganized thoughts

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12
Q

negative symtpoms of scizo

A

does not refer to attitude, but instead a lack of characteristics that should be present
reduced speech
lack of emotional and facial expression
diminished abiligt to begin and sustain activities
decreased ability to find pleasure in everyday
social w/draw

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13
Q

cognitive deficits

A

difficilties w/ following aspects of cognition can make it hard to live a normal life or earn a living
memory
attention
planning
decision making

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14
Q

what are delusions

A

Fixed false personal belief that does not
change when confronted with conflicting evidence

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15
Q

what are persecutory delusions

A

paranoid

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16
Q

what are grandiose delusions

A

exaggerated feeling of importance

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17
Q

somatic delusions

A

body function

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18
Q

erotomanic delusions

A

in love with him or her

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19
Q

jealous delusions

A

irrational w/out cause

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20
Q

reference delusions

A

Events in environment refer to him
or her, i.e. radio is talking to them

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21
Q

what is paranoia

A

Extreme suspiciousness of others

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22
Q

what is magical thinking

A

Ideas that one’s thoughts or
behaviors have control over specific situations

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23
Q

wha is loose associaion

A

Shift of ideas from one unrelated topic to another

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24
Q

what are neologisms

A

Made-up words that have meaning only to the person who invents them

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25
Q

what is concrete thinking

A

Literal interpretations of the environment

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26
Q

what are clang associations

A

Choice of words is governed by sound (often rhyming)

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27
Q

what is word salad`

A

Group of words put together in a random fashion

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28
Q

what is circumstantiality

A

Delay in reaching the point of a communication because of unnecessary
and tedious details

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29
Q

what is tangentiality

A

Inability to get to the point of communication due to introduction of many new
topics

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30
Q

what is perseveration

A

Persistent repetition of the same word or idea in response to different
questions

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31
Q

what hallucination is most common in scizo

A

auditory

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32
Q

what are illusions

A

misperceptions of real external stimuli

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33
Q

what is echolalia

A

repeating words that are heard

34
Q

what is echopraxia

A

repeating movements that are observed

35
Q

what is apathy

A

disinterest in the enviornment

36
Q

what is avolition

A

Impairment in the ability to
initiate goal-directed activity

37
Q

what is emotional ambivalence

A

Coexistence of
opposite emotions toward same
object, person, or situation

38
Q

what is associality

A

Impaired interpersonal functioning and relationship external world

39
Q

what is anergia

A

deficiency of energy

40
Q

what is anosognosia

A

Impairment of a person’s ability to
understand and perceive their illness

41
Q

what is waxy flexibilty

A

Passive yielding of all movable parts of the body to any effort
made at placing them in certain positions

42
Q

what is posturing

A

voluntary assumption of inappropriate or bizarre postures

43
Q

what is catatonia

A

Significant motor disturbance that may range from stupor (no motor
activity) to excessive motor activity and agitation

44
Q

FGA/Typical antipsychotics moa

A

block postsynaptic dopamine receptors in the basal ganglia, hypothalamus, limbic system, brainstem, and medulla
address positive symptoms

45
Q

loxapine

A

fga/typical antipsychotics

46
Q

haloperidol

A

fga/typical antipsychotics

47
Q

PIMOZIDINE

A

fga/typical antipsychotics

48
Q

cholpromazine

A

fga/typical antipsychotics

49
Q

fluphenazine

A

fga/typical antipsychotics

50
Q

mesoridazine

A

fga/typical antipsychotics

51
Q

perphenazine

A

fga/typical antipsychotics

52
Q

prochlorperazine

A

fga/typical antipsychotics

53
Q

sg2/atypical antipsychoitcs moa

A

weaker dopamine receptor antagonists than FGAs
but are more potent antagonists of the serotonin 5HT2A receptors

54
Q

clozapine

A

SGA/Atypical antipsychotics

55
Q

risperodone

A

SGA/Atypical antipsychotics

56
Q

paliperidone

A

SGA/Atypical antipsychotics

57
Q

olanzapine

A

SGA/Atypical antipsychotics

58
Q

quetiapine

A

SGA/Atypical antipsychotics

59
Q

ziprasidone

A

SGA/Atypical antipsychotics

60
Q

aripiprazole

A

SGA/Atypical antipsychotics

61
Q

clozapine

A

SGA/Atypical antipsychotics
risk for infection

62
Q

lais

A

Historically used for treating clients with schizophrenia who relapse due to nonadherence.
 Now clients may be treated with LAI if it is their preference without demonstrating a history
of nonadherence
 Injections administered every 2 or 4 weeks

63
Q

antipsychotic side effects

A

Metabolic Syndrome
* Extrapyramidal symptoms (EPS)
dyskinesia
* Neuroleptic malignant syndrome
* Agranulocytosis (clozapine):
* Anticholinergic effects
* Hormonal effects (prolactin)
* EKG changes (QT prolongation)
* Sedation
* Orthostatic hypotension
* Nausea; gastrointestinal upset
* Skin rash
* Photosensitivity
* Increased risk of mortality in elderly clients with dementia

64
Q

symptoms of neroleptic malignant syndrome

A

fever, confusion, muscle rigidity, diaphoresis, and tachycardia. Life threatening

65
Q

monitoring for agranilocytosis

A

monitor CBC with Diff/ANC (absolute neutrophil count)

66
Q

what labs to look at with metabolic syndrome

A

↑weight, ↑cholesterol/lipids, ↑BG, ↑BP, ↑waist circumference

67
Q

extrapyramidal symptoms

A

akathisia, pseudoparkonsonism, dystonia, tardive

68
Q

what is dystonia

A

uncontrolled muscular spasm

69
Q

s+s of eps

A

dystonia
pseudoparkinsonism
akathisia
tardive dyskinesia

70
Q

what is pseudoparkinsonism

A

tremor/bradykinesia

71
Q

what is akathisia

A

restlessness

72
Q

what is tardive dyskinesia

A

abnormal involuntary movements

73
Q

treatment for dystonic reaction

A

im/iv diphenhydramine

74
Q

most dystonic reactions occur where

A

neck and above

75
Q

which drugs mostly cause eps

A

1st gen antipsychoics

76
Q

what is used to treat eps

A

benzotropine and diphenhydramine

77
Q

benzotropine

A

anticholinergic

78
Q

what to know about fga

A

Positive symptoms
- Risk for TD
- EPS
- Low risk of cardiometabolic side effects
- Cheap

79
Q

what to know about sgas

A

Positive Symptoms and some benefit with negative symptoms,
- Very low risk of TD
- Lower risk of EPS
- Risk of cardiometabolic side effects
- Clozapine is oldest SGA and has additional monitoring due to risk of agranulocytosis

80
Q

what is aripiprazole tablet with sensor used to treat

A

scizo
bipolar 1
mdd

81
Q

monitoring for clozapine

A

weekly bloodwork
report s/s of infection

82
Q
A