Aminosalicylates Flashcards
(5 cards)
1
Q
What is 5-aminosalicylic acid a first line treatment for?
A
Ulcerative Colitis
2
Q
What are the mode of actions for 5-aminosalicylic acid?
A
- Antiinflammatory activity
- Immunosuppressive activity
- Antioxidant activity
3
Q
Where in the GI tract is the inflammation/ulcerations/lesions found?
A
Lower GI Tract
4
Q
How is 5-aminosalicylic acid modified to make a pro drug?
A
An azo bond is added.
-> Broken down by bacterial azoreductase to form active drug
5
Q
How can 5-aminosalicylic acid be protected until it reaches the colon?
A
pH-dependent coated tablet/capsule
-> broken down at a very low pH
