Steroids Flashcards
(7 cards)
1
Q
What does structure of a steroid look like?
A
Honeycomb - hexagons and pentagons together
2
Q
What are the 2 positions of a benzene ring?
A
- Axial
- Equatorial
3
Q
What are the 2 types of ring junctions of a benzene ring?
A
- Trans-decalin (more preferred)
- Cis-decalin
4
Q
What is the starting material for the synthesis of steroid hormones?
A
Cholesterol
5
Q
What are the 2 types of adrenocorticoids?
A
- Mineralocorticoids
- Glucocorticoids
6
Q
What is done to steroidal drugs to prevent metabolism?
A
Halogens (Cl and F) added.
-> electronegativity creates dipole
-> inductive effect makes H on OH a better donor
7
Q
What is metabolised of a pro drug to make it active?
A
Ester group
