Aminosalicylates overall

Question 1

Aminosalicylates examples

Answer 1

Balsalazide
Mesalazine
Olsalazine
Sulfasalazine

Question 2

Key interaction- Mesalazine

Answer 2

MR mesalazine can be affected by drugs which alter gut PH.

Lactulose may prevent the drug being released where it was intended to be released in the GI tract

Question 3

Mesalazine and renal impairment

Answer 3

Caution
Avoid if below 20ml/min

Question 4

Brands and mesalazine

Answer 4

Different brands of oral mesalazine may produce differing delivery properties. This is the case especially in MR preps

Question 5

Mesalazine interactions

Answer 5

Nephrotoxic agents which are taken will increase the risk of renal issues