AML Risk Status Flashcards Preview

Heme Week 2 > AML Risk Status > Flashcards

Flashcards in AML Risk Status Deck (9)
Loading flashcards...
1

The three "risk" categories associated with AML include:

Better risk
intermediate risk
Poor-risk

2

What cytogenetic findings would suggest better risk AML?

inv(16)
t(8,21)
t(15,17)

3

What cytogenetic findings would suggest intermediate risk AML?

normal cytogenetics
+8 alone
t(9,11)
other non-defined

4

What cytogenetic findings would suggest poor risk AML?

complex karyotypes
monosomal karyotypes
-5,-5q,-7, -7q
11q23- non t(9,11)
inv(3)
t(6,9)
t(9,22)

5

What molecular abnormalities would suggest better risk AML?

Normal cytogenetics: NPM1 mutation in the absence of FTL3-ITD or isolated biallelic CEBPA mutation

6

What molecular abnormalities would suggest intermediate risk AML?

t(8,21), inv(16), with c-KIT mutation

7

What molecular abnormalities would suggest poor risk AML?

Normal cytogenetics with FLT3-ITD mutation

8

How would a high sick patient be treated?

allogeneic SCT

9

How would an intermediate/low risk patient be treated?

chemo alone