Flashcards in Drugs in Heme Malignancies Deck (4)
What governs design of chemo combo treatment regimens?
Toxicity of “classical” anticancer agents
What is the basic outline of how chemo combo regimens work?
HIGH dose (very toxic; induction therapy) followed
by LOWER dose (less toxic; consolidation therapy)
– Drugs used alone or accompanied by adjunctive
What governing guidelines must chemo combos follow?
Drug MUST show activity against tumor type
– No two drugs should have the same mechanism of action
– Drugs should have different patterns of dose-limiting