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Flashcards in Drugs in Heme Malignancies Deck (4)
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1

What governs design of chemo combo treatment regimens?

Toxicity of “classical” anticancer agents

2

What is the basic outline of how chemo combo regimens work?

HIGH dose (very toxic; induction therapy) followed
by LOWER dose (less toxic; consolidation therapy)
– Drugs used alone or accompanied by adjunctive
radiotherapy

3

What governing guidelines must chemo combos follow?

Drug MUST show activity against tumor type
– No two drugs should have the same mechanism of action
– Drugs should have different patterns of dose-limiting
toxicity

4

APL drugs?

arsenic trioxide and ATRA