Flashcards in Analgesics and Anti-inflammatories - NSAIDS (2) Deck (10):
Ibuprofen: Basic pharmacodynamics?
Reversibly inhibits cylooxygenase (COX-1 and COX-2), preventing the production of prostaglandins and thromboxane A2.
Should ibuprofen be taken with food?
Yes - with food, milk or antacids, to reduce the risk of GIT adverse effects. However, food will slow the absorption of ibuprofen.
Describe the key drug interaction between ibuprofen and warfarin.
Both are highly protein-bound, so ibuprofen will cause displacement of warfarin from albumin which can cause fatal haemorrhage.
Name two contraindications to ibuprofen.
Asthmatics - inhibition of COX means that more arachidonic acid will be converted to leukotrienes, which cause bronchospasm.
3rd trimester of pregnancy - can cause closure of the fetal ductus arteriosus.
Ibuprofen is metabolized in the ______ and excreted in the ______.
Metabolized in the liver, excreted in the urine.
Naproxen - describe two differences between naproxen and ibuprofen.
Naproxen's incidence of GIT bleeding is double that of ibuprofen. The half-life of naproxen is much longer: 12 hours.
Diclofenac - describe the basic pharmacodynamics.
Non-selective COX inhibitor. Also inhibits lipoxygenase.
Diclofenac - routes of administration?
Orally, rectally, topical gel, eye drops...