Analgesics and Anti-inflammatories - NSAIDS (2) Flashcards Preview

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Flashcards in Analgesics and Anti-inflammatories - NSAIDS (2) Deck (10):
1

Ibuprofen: Basic pharmacodynamics?

Reversibly inhibits cylooxygenase (COX-1 and COX-2), preventing the production of prostaglandins and thromboxane A2.

2

Should ibuprofen be taken with food?

Yes - with food, milk or antacids, to reduce the risk of GIT adverse effects. However, food will slow the absorption of ibuprofen.

3

Describe the key drug interaction between ibuprofen and warfarin.

Both are highly protein-bound, so ibuprofen will cause displacement of warfarin from albumin which can cause fatal haemorrhage.

4

Name two contraindications to ibuprofen.

Asthmatics - inhibition of COX means that more arachidonic acid will be converted to leukotrienes, which cause bronchospasm.
3rd trimester of pregnancy - can cause closure of the fetal ductus arteriosus.

5

Ibuprofen is metabolized in the ______ and excreted in the ______.

Metabolized in the liver, excreted in the urine.

6

Ibuprofen: half-life?

2 hours.

7

Naproxen - describe two differences between naproxen and ibuprofen.

Naproxen's incidence of GIT bleeding is double that of ibuprofen. The half-life of naproxen is much longer: 12 hours.

8

Diclofenac - describe the basic pharmacodynamics.

Non-selective COX inhibitor. Also inhibits lipoxygenase.

9

Diclofenac - routes of administration?

Orally, rectally, topical gel, eye drops...

10

Ketorolac - half-life?

5-6 hours.

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