Anaplylaxis Flashcards
(10 cards)
What is anaphylaxis?
The worst form of allergic condition or acute event: immediate hypersensitivity
What is anaphylaxis defined by?
Severity of the reaction, not the cause
What must happen before anaphylaxis can occur?
Sensitization and re-exposure
What happen during sensitization?
Initial sensitization to Ag occurs
What happens upon re-exposure?
IgE binds to mast cells: leading to release of granules
What is released from mast cells?
Histamine
Prostaglandins
Leukotrienes
What are common symptoms of Anaphylaxis?
Rash
Hypotension, Tachycardia
Respiratory Distress: SOB, wheezing, selling of lips/tongue/face, stridor
How do you treat anaphylaxis?
IM Epinephrine
Antihistamines
Glucocorticoids
Emergent airway protection: intubation or cricothyroidotomy
What are common antihistamine drugs used for anaphylaxis?
Diphenhydramine: H1 blocker
Cimetidine: H2 blocker
What are common glucocorticoid drugs used for anaphylaxis?
Methylprednisolone or Hydrocortisone
