Angioedema Flashcards
(13 cards)
What is angioedema?
sudden swelling of the face, tongue, eyes and airway
What is a common cause of Angioedema?
C1 Esterase Inhibitor Deficiency
What is the onset of angioedema associated with?
Minor physical trauma or the recent start of ACE-I
What is hereditary angioedema characterized by?
Sudden facial swelling and stridor without pruritus and urticaria
What treatments does hereditary angioedema not respond to?
Glucocorticoids or Epinephrine
What are the best initial tests for angioedema?
Decreased levels of C2 and C4
deficiency of C1 esterase inhibitor
What is the first step in managing angioedema?
Ensure the airway
What are management options for Acute attacks?
Fresh Frozen Plasma, Ecallantide and Icatibant
What is the mechanism of Ecallantide?
Kallikrein inhibitor
What is the mechanism of Icatibant?
Bradykinin B2 receptor antagonist
What can be used for prophylaxis before surgical and dental procedures?
Antifibrinolytics: Tranexamic acid: decrease C1 and bradykinin
Androgens: Danazol, Stanazol
Infusion of C1 esterase inhibitor
What is the mechanism of Lanadelumab for Angioedema?
Ab against Kallikrein
What do you use to treat Herditary angioedema with severe laryngeal involvement?
C1 Esterase Inhibitor concentrate
