Anatomy Basics

Question 1

Pri vs sec immu se system organs

Answer 1

Pri are bm and thymus for maturation
Sec are lymph node,tonsil,spleen where the cells react with antigen

Question 2

Part of lymph node missing in digeorge syndrome and enlarged in viral infection

Answer 2

Paracortex(has T cells)

Question 3

Mhc 1

Answer 3

Coded by Hla ABC
All nucleated cells
pres endogenous antigens
1 long chain and 1 sh chain

Question 4

MHC 2

Answer 4

HLA DR DQ CODING
APC
EXOG AN
TH CELL
2 EQUAL LENGTH CHAINS

Question 5

What disease is associated with HLA type A3?

Answer 5

Hemochromatosis

HLA A3 is linked to the genetic condition hemochromatosis, which causes excessive iron accumulation in the body.

Question 6

Which diseases are associated with HLA type B8?

Answer 6

• Myasthenia Gravis
• Addison’s disease
• Graves’ disease

HLA B8 is linked to autoimmune conditions including Myasthenia Gravis, Addison’s disease, and Graves’ disease.

Question 7

What diseases are associated with HLA type B27?

Answer 7

• Psoriatic arthritis
• Ankylosing spondylitis
• Inflammatory bowel disease-associated arthritis
• Reactive arthritis

HLA B27 is associated with several inflammatory arthritides, including psoriatic arthritis and ankylosing spondylitis.

Question 8

HLA types DQ2 and DQ8 are associated with which condition?

Answer 8

Celiac disease

DQ2 and DQ8 are HLA types that predispose individuals to celiac disease, an autoimmune disorder triggered by gluten.

Question 9

Which diseases are associated with HLA type DR2?

Answer 9

• Goodpasture’s syndrome
• Systemic lupus erythematosus (SLE)
• Rheumatoid arthritis

HLA DR2 is linked to autoimmune diseases such as Goodpasture’s syndrome and systemic lupus erythematosus.

Question 10

What is the association of HLA type DR4?

Answer 10

• Type 1 diabetes mellitus
• Rheumatoid arthritis
• Addison’s disease

HLA DR4 is associated with autoimmune diseases like type 1 diabetes and rheumatoid arthritis.

Question 11

HLA type DR5 is associated with which disease?

Answer 11

Hashimoto’s thyroiditis

HLA DR5 is linked to Hashimoto’s thyroiditis, an autoimmune condition affecting the thyroid gland.

Question 12

Which diseases are associated with HLA type DR3?

Answer 12

• Systemic lupus erythematosus (SLE)
• Type 1 diabetes mellitus
• Graves’ disease
• Hashimoto’s thyroiditis
• Addison’s disease

HLA DR3 is associated with multiple autoimmune diseases, including SLE and Graves’ disease.

Question 13

Nuetrophils margination, rolling,activ,adhesion, transmigration

Answer 13

Vess3l leaks makes blood thick, selectins(L on N and E and p on Endo), activ(chemokines), adhesion(icam-1), transmig
(Pecam-1)

Question 14

POS and negative selection

Answer 14

Thymus cortex(T cells that recognise self An)
Medulla( removes T cell that bind too strongly)

Question 15

T reg

Answer 15

Prod IL 10, TGFB, AND FOXP3

Question 16

Ab hinges

Answer 16

Inc avidity and inc destruction by bacterial proteases
It AGD

Question 17

Opsonins

Answer 17

C3b and igG

Question 18

C1 esterase inhib

Answer 18

Dec C4 in blood, angioedema bcs inc kinins, C/I ACE inhib

Question 19

Def of C1-C4

Answer 19

Risk of SLE

Question 20

Mac complex def

Answer 20

Neiseria inf

Question 21

Catalase org

Answer 21

Staph A and aspergillus break h2o2 and no phagocyte chem killing