Hypersensitivity And Transfusion Reactions

Question 1

Anaphylaxis
Allergy
Skin test fr allergen

Answer 1

Type 1
IgE and mast cell mediated
Tryptase is a marker of mast cell activ

Question 2

Epinephrine fr anaphylaxis

Answer 2

SNS effects and inhibit mast cell degranulation

Question 3

Coombs test
Blood transfusion mismatch
Itp
Aiha
Goodpasteur( linear ab an complex
RF
Hyper acute transplant reaction
MG
Graves
p vulgaris
Hint( notice how last 3 are one organ diseases)

Answer 3

Type 2 cytotoxic killing

Ab binds an that’s cell bound
Complem activ of opsonisation

Question 4

PSGN
IGa vasculitis
RA
SLE RA
pAN
Serum sickness after penicillin or inf
Arthur’s reaction

Answer 4

Type 3 immune complex deposition

Arthus(skin raised after booster shot)
Serum sickness dec c3 and C4

Question 5

Touch
transplant rejection
Tb candida test
DRESS

Answer 5

Delayed with T cell activation

Question 6

A man started having sob and itching when BT started

Answer 6

Allergic transfusion reaction type 1 reac
Due to donor plasma protein

Question 7

Same day blood transfusion wa sone pt had fever tachy and dark urine

Answer 7

Acute hemolysis type 2 hyp
Abo incompatible

Question 8

Child developed fever after transfusion

Answer 8

Febrile non hemolytic due to cytokines in donor blood

Question 9

Sob, plum edema within 6 hours of transfusions

Answer 9

Acute lung injury cute to neutrophils activ by donor antileukocyte ab

Question 10

One week later mild fever

Answer 10

Rh or other an incompatibility
Delayed reaction