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PHRM 825 > Androgens > Flashcards

Androgens Flashcards

1
Q

GnRH

A

gonadotropin releasing hormone
secreted by hypothalamus
stimulates cells in anterior pituitary

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2
Q

LH

A

luteinizing hormone
secreted by anterior pituitary
stimulates Leydig cells in testis to release testosterone

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3
Q

FSH

A

follicle stimulating hormone
secreted by anterior pituitary
stimulates Sertoli cells and spermatogenesis

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4
Q

testosterone effects

A

changes at puberty
growth promotion (hair, penis, skin, voice)
stimulation sexual function
stimulation erythrocyte production
decrease HDL levels

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5
Q
A

androstenedione

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6
Q
A

DHEA

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7
Q
A

DHEAS

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8
Q
A

methyltestosterone (oral)

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9
Q
A

testosterone enanthate (intramuscular)

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10
Q
A

testosterone cypionate (intramuscular)

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11
Q

adverse effects androgens in women

A

hirsutism, acne, amenorrhea, clit enlargement, deep voice

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12
Q

adverse effects androgens in men

A

acne, sleep apnea, azoospermia and testicular atrophy, increased aggressiveness and psychotic symptoms

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13
Q

5 alpha reductase inhibitors

A

finasteride and dutasteride

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14
Q

finasteride (class and uses)

A

5 alpha reductase inhibitor
benign prostatic hyperplasia (Proscar)
male pattern baldness (Propecia)
hirsutism in women

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15
Q

dutasteride (class and uses)

A

5 alpha reductase inhibitor
benign prostatic hyperplasia
male pattern baldness

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16
Q

steroidal androgen receptor inhibitors

A

cyproterone/cyproterone ester, spironolactone

17
Q

cyproterone/cyproterone ester (class and uses)

A

steroidal androgen receptor inhibitor
hirsutism in women
excessive sexual drive in men

18
Q

spironolactone (class and uses)

A

steroidal androgen receptor inhibitor
hirsutism in women
acne

19
Q

non-steroidal androgen receptor inhibitors

A

flutamide and enzalutamide

20
Q

flutamide (class and use)

A

non-steroidal androgen receptor inhibitor
prostate cancer

21
Q

enzalutamide (class and use)

A

non-steroidal androgen receptor inhibitor
metastatic castration resistant prostate cancer (spreading)

PHRM 825 (24 decks)

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