Sympathomimetics

Question 1

monoamine

Answer 1

amino group connected to aromatic ring by two carbons

Question 2

catecholamine

Answer 2

monoamine with catechol (benzene with two hydroxy)

Question 3

biosynthesis catecholamines

Answer 3

L-Tyrosine
L-DOPA
Dopamine
Norepinephrine
Epinephrine

Question 4

norepinephrine neurotransmission

Answer 4

tyrosine into ending, then to dopa
dopamine into vesicle by VMAT
dopamine to NE
calcium opens channel and vesicles fuse
NE binds adrenergic receptors

Question 5

stereochemical requirements for adrenoceptor binding

Answer 5

catechol
amine
hydroxy
R stereochemistry

Question 6

epinephrine receptor selectivity

Answer 6

more selective beta but alpha 1 and 2 beta 1 and 2

Question 7

norepinephrine receptor selectivity

Answer 7

alpha 1 and 2 and beta 1 NO BETA 2

Question 8

alpha 1 receptor Gq

Answer 8

vasocontriction
pupil dilation
ejaculation
urine inhibition
GI inhibition

Question 9

alpha 2 receptor Gi

Answer 9

vasoconstriction
prejunctional NE inhibition
in cns decrease CV SNS input

Question 10

beta 1 receptor Gs

Answer 10

cardiac stimulation
renin secretion

Question 11

beta 2 receptor Gs

Answer 11

cardiac stimulation
bronchodilation
uterine relaxation
GI inhibition
vasodilation

Question 12

what do alpha 1 agonists due

Answer 12

nasal decongestion
vascular failure in shock and tachycardia

Question 13

why is phenylephrine not very effective? first pass metabolism

Answer 13

cant reach site, broken down in the liver

Question 14

where is alpha 1 found?

Answer 14

smooth muscle, heart, liver

Question 15

alpha 1 drug structure

Answer 15

imidazoline connected to carbon

Question 16

where is alpha 2 found?

Answer 16

pre synaptically

Question 17

what do alpha 2 agonists do

Answer 17

hypertension
pain
glaucoma
inhibit SNS activity

Question 18

methyldopa is a

Answer 18

prodrug, not very soluble tho so methyldopate used for iv

Question 19

where is beta 1 found

Answer 19

heart, kidney

Question 20

what do beta 1 agonists do

Answer 20

shock, congestive heart failure

Question 21

what do beta 1 antagonists do

Answer 21

hypertension, angina, arrhythmias, congestive heart failure

Question 22

where is beta 2 found

Answer 22

smooth muscle

Question 23

what do beta 2 agonists do

Answer 23

asthma, premature labor

Question 24

what do beta 2 antagonists do

Answer 24

glaucoma

Question 25

where is beta 3 found

Answer 25

urinary bladder

Question 26

what does beta 3 agonist do

Answer 26

overactive bladder

Question 27

2 meta hydroxys on benzene ring receptor type

Answer 27

beta 2

Question 28

indirect acting sympathomimetics structure

Answer 28

no MAO or COMT

Question 29

lack of hydroxyl on indirect effect

Answer 29

increased CNS activity

Question 30

how to get from amphetamine to methamphetamine

Answer 30

lose beta carbon

Question 31

how do maois work

Answer 31

NE can not degrade, increased sympathetic action

Question 32

tyramine

Answer 32

high levels in beer/cheese/wine, increase NE which could lead to hypertensive crisis

Question 33

NET inhibitors action

Answer 33

inhibit reuptake of NE so it stays in the synaptic cleft

Question 34

non stim ADHD meds

Answer 34

atomoxetine, guanfacine, clonidine

Question 35

stim ADHD meds

Answer 35

methylphenidate, amphetamine