Androgens

Question 1

More lipophilic. Given IM. Longer duration - need to be given every 2/4 weeks

Answer 1

Testosterone esters - cypionate and enanthate

Question 2

Used for hypogonadism and metastatic breast cancer in women

Answer 2

Testosterone esters - cypionate and enanthate.

17 alpha-alkylated testosterone.

Question 3

Orally effective. Methyltestosterone and fluoxymesterone

Answer 3

17 alpha-alkylated testosterone

Question 4

High abuse potential due to anabolic activity

Answer 4

17 alpha-alkylated testosterone

Question 5

Avoid in male Breast cancer, prostate cancer, and pregnancy

Answer 5

17 alpha-alkylated testosterone

Question 6

Low doses will cause cholestatic hepatitis and jaundice

Answer 6

17 alpha-alkylated testosterone

Question 7

Greatest risk of hepatotoxicity

Answer 7

17 alpha-alkylated testosterone - methyl testosterone and fluoxymesterone

Question 8

Can cause edema, liver cancer, and bleeding due to clotting factor deficiencies 2,5,7,10

Answer 8

17 alpha-alkylated testosterone - methyltestosterone and fluoxymesterone

Question 9

Contraindications for all ______ include prostate cancer, pregnancy, and male breast cancer

Answer 9

Testosterone analogues

Question 10

Greatest risk of jaundice

Answer 10

17 alpha-alkylated testosterone methyltestosterone and fluoxymesterone

Question 11

Depresses preovulatory surge of FSH and LH, suppresses mid cycle surge of FSH and LH, reduces ovarian estrogen and progesterone production

Answer 11

Danazol

Question 12

Causes weight gain in women

Answer 12

Danazol

Question 13

Used for endometriosis

Answer 13

Danazol

Question 14

Can cause acne and thrombosis

Answer 14

Danazol

Question 15

Avoid in pregnancy and breast feeding

Answer 15

Danazol

Question 16

Testosterone derivative with strong anabolic action

Answer 16

Stanazolol

Question 17

Used for hereditary angioedema

Answer 17

Stanazolol

Question 18

Big risk of hepatic toxicity

Answer 18

Stanazolol

Question 19

Avoid in pregnancy, male breast or prostate cancer, and female breast cancer with hypercalcemia

Answer 19

Stanazolol

Question 20

Testosterone cypionate and enanthate

Answer 20

Testosterone esters

Question 21

High anabolic to androgeic ratio. Approved for use of weight gain in pts that had extensive surgery, severe trauma, or long term corticosteroids

Answer 21

Oxandrolone

Question 22

Finasteride and dutasteride

Answer 22

Antiandrogens

Question 23

Reduce levels of dihydrotestosterone

Answer 23

Antiandrogens finasteride and dutasteride

Question 24

Testosterone > DHT by

Answer 24

5 alpha-reductase

Question 25

Competitive inhibitor of type 2 5-alpha reductase

Answer 25

Finasteride

Question 26

Competitive inhibitor of type 1 and 2 forms 5-alpha reductase

Answer 26

Dutasteride

Question 27

Used for BPH. May take 6 months to reduce size of prostate

Answer 27

Antiandrogens - finasteride and dutasteride

Question 28

Tamsulosin and alfuzosin

Answer 28

Alpha 1 adrenergic inhibitors

Question 29

Decrease smooth muscle tone in prostate and bladder neck

Answer 29

Alpha 1 inhibitors tamsulosin and alfuzosin

Question 30

Lower PSA levels by 50%

Answer 30

Antiandrogens - finasteride and dutasteride