Neuropharm3

Question 1

Lack of ADH

Answer 1

Diabetes insipidus

Question 2

Inadequate ADH releases

Answer 2

Central diabetes insipidus

Question 3

Lack of ability to respond to ADH

Answer 3

Nephrogenic diabetes insipidus

Question 4

Hypercalcemia, hypokalemia, post obstructive renal failure

Answer 4

Nephrogenic diabetes insipidus

Question 5

Treat diabetes insipidus by adjusting

Answer 5

Fluid intake

Question 6

Synthetic analog of vasopressin. Has reduced vasopressor activity, but enhanced anti-diuretic activity compared with vasopressin

Answer 6

Desmopressin

Question 7

Also used for Von-willebrand disease type 1 and primary nocturnal enuresis

Answer 7

Desmopressin

Question 8

Vasopressor activity is due to activation of _______ receptor

Answer 8

V1

Question 9

Facial pallor, increases in GI activity causing nausea and cramps, vasoconstriction of coronary arteries

Answer 9

Vasopressin - more prominent than desmopressin effects

Question 10

Higher activity toward V1 receptor

Answer 10

Vasopressin

Question 11

Overstimulation of ____ receptor in tubules causes water intoxication

Answer 11

V2

Question 12

Chlorpropamide and carbamazepine increase sensitivity of collecting duct to

Answer 12

Vasopressin

Question 13

Lithium and demeclocycline will inhibit ________ on collecting duct

Answer 13

Vasopressin

Question 14

Lithium associated with

Answer 14

Nephrogenic diabetes insipidus

Question 15

Treatment includes adequate water intake (thiazide diuretics and restriction of sodium intake) and amiloride

Answer 15

Treatment of Nephrogenic diabetes insipidus

Question 16

Blocks lithium uptake by Na channel into collecting duct. Used to reverse lithium induced Nephrogenic diabetes insipidus

Answer 16

Amiloride

Question 17

Hyponatremia, hypo-osmolality

Answer 17

SIADH

Question 18

Can be causes by SSRIs, TCAs, sulfonylureas, vinca alkaloids

Answer 18

SIADH

Question 19

Plasma hypotonicity, lethary, anorexia, N/V, muscle cramps, coma, convulsions, and death

Answer 19

SIADH

Question 20

Treatment by fluid restriction

Answer 20

SIADH

Question 21

V1 and V2 receptor antagonist

Answer 21

Conivaptan

Question 22

Selective V2 receptor antagonist

Answer 22

Tolvaptan

Question 23

Used for abortion, adjunct, inducing labor, postpartum hemorrhage, and induction of lactation

Answer 23

Oxytocin

Question 24

Synthetic oxytocin given IV for

Answer 24

Inducing labor

Question 25

Synthetic oxytocin given IM for

Answer 25

Controlling post partum hemorrhage

Question 26

Synthetic oxytocin given intranasally for

Answer 26

Inducing lactation

Question 27

Overstimulation can cause trauma to mother or fetus, uterine rupture, water intoxication, and allergic rxs

Answer 27

Oxytocin

Question 28

Blocks conversion of testosterone to DHT. Prostate tissue shrinks. Used to treat benign BPH

Answer 28

5 alpha reductase inhibitor (finasteride)