anemia

Question 1

a group inherited disorders
that lead to a decrease synthesis
of the alpha or beta chains of
hemoglobin.
The RBC are malformed and
contain less hemoglobin.
Common among people of
Mediterranean descent

Answer 1

Thalassemias

Question 2

Anemias due to deficient red blood cell production include many nutritional
conditions including:

Answer 2

o Iron deficient anemia
o Megaloblastic anemias
o Aplastic anemias

Question 3

Iron deficient anemia is the
result of a

Answer 3

dietary deficiency or
loss of iron. In women, menstruation can
lead to a 1.5 mg per day loss of
iron, making this very common
in this group.

Question 4

Megaloblastic anemias are
caused by an impaired

Answer 4

DNA synthesis that results
in enlarged red cells due
to impaired maturation
and division. The two most common
causes are Vitamin B12 or
a folic acid deficiency.

Question 5

a disorder
that results in the reduction of all three
of the hematopoietic blood lines.
Signs and symptoms include weakness,
fatigability and pallor due to anemia.
Petechiae and ecchymoses due to
decreased platelets and increase
incidence of infection.

Answer 5

Aplastic anemias

Question 6

 Secreted when oxygen in peripheral tissues is low (hypoxia)
 Due to disease or high altitude

Answer 6

 Erythropoietin (EPO

Question 7

John recently moved to the Rocky Mountains. His house is at an
altitude of 12,000 feet. What type of changes would occur in his blood
profile?

Answer 7

 The low oxygen levels would stimulate the secretion of erythropoietin.
 This would lead to the stimulation of erythroblastic activity and RBC
formation

Question 8

Surface Antigen

Answer 8

Are cell surface proteins that identify cells to immune system
 Normal cells are ignored and foreign cells attacked

Question 9

How are blood types determined?

Answer 9

 Are genetically determined
 By presence or absence of RBC surface antigens A, B, Rh

Question 10

 Antigens on surface of RBCs
 Screened by immune system
 Plasma antibodies attack and agglutinate (clump) foreign antigens

Answer 10

Agglutinogens

Question 11

 Blood Plasma Antibodies
 Type A

Answer 11

 Type B antibodies

Question 12

 Blood Plasma Antibodies
 Type B

Answer 12

Type a antibodies

Question 13

 Type O

Answer 13

 Both A and B antibodies

Question 14

Type AB

Answer 14

Neither A nor B antibodies

Question 15

The Rh Factor

Answer 15

 Also called D antigen
 Either Rh positive (Rh
) or Rh negative (Rh)
 Only sensitized Rh blood has anti-Rh antibodies