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Hema 1 part 1 > Anemia (Macrocytic) > Flashcards

Anemia (Macrocytic) Flashcards

1
Q

Examples of Megaloblastic Anemia

A

Vit B12 deficiency
Folic Acid Deficiency

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2
Q

Non-Megaloblastic Anemia:
Examples

A

Liver disease
Chronic alcoholism
Bone Marrow Failure
Reticulocytosis
Normal macrocytosis of newborns

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3
Q

Megaloblastic anemia:
DNA metabolism

A

defective

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4
Q

Non-Megaloblastic anemia:
DNA metabolism

A

Normal

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5
Q

Megaloblastic Anemia:
MCV:

A

↑ 100-150fl

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6
Q

Megaloblastic anemia:
Pancytopenia

A

+

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7
Q

Non-Megaloblastic anemia:
Pancytopenia

A

-

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8
Q

Megaloblastic anemia:
Macro-ovalocytes

A

+

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9
Q

Non-Megaloblastic anemia:
Macro-ovalocytes

A

-

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10
Q

Megaloblastic anemia:
Hyper-segmented neutrophils

A

+

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11
Q

Non-Megaloblastic anemia:
Hyper-segmented neutrophils

A

-

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12
Q

Vit B12 Deficiency:
Serum Vit B12

A

↓

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13
Q

Folic Acid Deficiency:
Serum Vit B12

A

N

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14
Q

Vit B12 Deficiency:
Serum Folate

A

Normal

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15
Q

Folic Acid Deficiency:
Serum Folate

A

↓

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16
Q

Vit B12 Deficiency:
Serum Methylmalonic
acid

A

↑

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17
Q

Folic Acid Deficiency:
Serum Methylmalonic
acid

A

Normal

18
Q

Vit B12 Deficiency:
Serum Homocysteine

A

↑

19
Q

Folic Acid Deficiency:
Serum Homocysteine

A

↑

20
Q

Vit B12 Deficiency:
Schilling’s Test

A

+

21
Q

Folic Acid Deficiency:
Schilling’s Test

A

-

22
Q

Vit B12 Deficiency:
Autoantibody to
parietal cells / IF

A

+

23
Q

Folic Acid Deficiency:
Autoantibody to
parietal cells / IF

A

-

24
Q

Vit B12 Deficiency:
Gastric analysis:

A

Achlorhydia

25
Q

Folic Acid Deficiency:
Gastric analysis:

A

Euchlorhydia

26
Q

radioactive test for assessment of measurement of vit B12

A

Schilling’s test

27
Q

absence of gastric acidity

A

Achlorhydia

28
Q

Root cause of Megaloblastic anemia is Impaired DNA metabolism which leads to cells division ______, _____ of progenitors in the bone marrow, ______ development

A

Failure
Apoptosis
Asynchronous

29
Q

Folate (pteroylglutamic acid) deficiency caused by:
* ____ intake
* _____ need, (such as in pregnancy)
* Impaired ____
* _____ protein deficiency
* drugs that impair _____
* Excessive ____ of folate

A

Inadequate
Increased
Absorption
Folate transporter
folate metabolism
Loss

30
Q

Vitamin B12 (Cobalamin) deficiency caused by:
Competition for Vit. B12, (w/ _____)

A

Diphyllobothrium latum

31
Q

Vitamin B12 (Cobalamin) deficiency caused by:
Defective production of intrinsic factor due to _______ infection

A

Helicobacter pylori

32
Q

Vitamin B12 (Cobalamin) deficiency caused by:
______ anemia
- Associated to ______ and _______

A

Pernicious
anti-parietal cell
anti-Intrinsic factor autoantibody

33
Q

Pernicious anemia symptoms:

A

Skin pallor
Jaundice
Peripheral neuropathy
Emotional instability
Atrophic gastritis

34
Q

MEGALOBLASTIC ANEMIA
Laboratory Findings: MCV

A

Macrocytosis

35
Q

MEGALOBLASTIC ANEMIA
Laboratory Findings: Blood smear

A

Macroovalocytes
hypersegmented neutrophils
Howell-Jolly (DNA
Remnants)
Cabot rings (mitotic spindle remnants)

36
Q

MEGALOBLASTIC ANEMIA
Laboratory Findings: CBC

A

Pancytopenia
Reticulocytopenia

37
Q

MEGALOBLASTIC ANEMIA
Laboratory Findings: Chemistry

A

↑ Serum B1 and LDH

38
Q

MEGALOBLASTIC ANEMIA
Laboratory Findings: Schilling Test

A

can detect absence of IF, but uses radioactive cobalamin

39
Q

MEGALOBLASTIC ANEMIA
Laboratory Findings: Bone Marrow Exam

A

Nuclear-cytoplasm asynchrony in cells
Large Progenitors (RBC and WBC)
Hypercellular Bone Marrow with increased apoptosis

40
Q

Reference Confirmatory test of megaloblastic anemia

A

Bone Marrow Exam

Hema 1 part 1 (6 decks)

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