RBC EXTRINSIC DEFECTS: IMMUNE CAUSES

Question 1

4 Major categories:
due to IgG (37C reactive)

Answer 1

WAIHA - Warm Autoimmune Hemolytic Anemia

Question 1

Characterized by premature RBC destruction and anemia caused by
autoantibodies that bind to the RBC surface with or without complement activation

Answer 1

Autoimmune Hemolytic Anemia (AIHA)

Question 2

4 Major categories:
due to IgM (4C- 30C)

Answer 2

CAD - Cold Agglutinin Disease

Question 3

4 Major categories:
caused by a biphasic IgG (reacts at 30 binds to RBC and at 37C which causes lysis due to complement activation) AKA Donath Landsteiner Ab

Answer 3

PCH - Paroxysmal Cold Hemoglobinuria

Question 4

PCH - Paroxysmal Cold Hemoglobinuria- caused by a biphasic IgG (reacts at 30 binds to RBC and at 37C which causes lysis due to complement activation) AKA ________

Answer 4

Donath Landsteiner Ab

Question 5

Alloimmune Hemolytic Anemia:
blood type incompatibility

Answer 5

Hemolytic Transfusion Reactions

Question 6

Blood bank test that detects HTR, HDN, AIHA, DIHA

Answer 6

Direct Antiglobulin Test

Question 7

Direct Antiglobulin Test detects _______ of RBCs

Answer 7

IN VIVO SENSITIZATION