RBC EXTRINSIC DEFECTS: NON-IMMUNE CAUSES

Question 1

Formation of schistocyte/ RBC
fragment

Answer 1

Microangiopathic Hemolytic anemia (MAHA)

Question 2

due to deficiency of ADAMTS13 due to cutting of VWF

Answer 2

Thrombotic thrombocytopenic purpura (TTP)

Question 3

due to E. coli OL57:H7- produces shiga like toxin

Answer 3

Hemolytic uremic syndrome (HUS)

Question 4

Hemolysis, elevated liver enzymes, low platele. count syndrome- low plt ct and clotting factors

Answer 4

HELLP

Question 5

Thrombotic thrombocytopenic purpura- due to
deficiency of _____ due to cutting of VWF

Answer 5

ADAMTS13

Question 6

HUS - Hemolytic uremic syndrome- due to ______ produces shiga like toxin

Answer 6

E. coli OL57:H7

Question 7

Hemolytic Anemia caused by Infectious agents
examples

Answer 7

Malaria
Babesiosis

Question 8

Hemolytic Anemia caused by RBC injuries
examples

Answer 8

drugs/chemicals
venoms
extensive burns