Flashcards in Anesthesia Review Deck (97):
What class of drug is thiopental?
The electrical potential at which the sodium channel goes from the closed to the open state is also known as?
Do local anesthetics work at the internal or external membrane of the sodium channel?
Thiopental is a strong base or strong acid?
Which intravenous anesthetic also has a post-operative effect against nausea/vomiting (anti-emetic properties)?
The unconsciousness induced by inhaled anesthetics is reversible or non-reversible?
Ketamine is most like what drug?
What is the treatment for local anesthetic toxicity?
True or False: Local anesthetics do not block sympathetic nerve
What is the effect of inhaled anesthetics on EEG?
"flatten it" isoelectric EEG
What disease is associated with inhaled anesthetics that increase the patient's temperature and may result in death?
Which inhaled anesthetic is least soluble in blood?
Which intravenous anesthetic resulted in more deaths at Pearl Harbor than the actual attack?
Emergence from inhaled anesthetics depends on which: elimination or metabolism?
Which local anesthetic has more rapid onset: Bipivucaine (pKa= 8.1); Lidocaine (pKa=7.9)
Lidocaine (pKa is closer to that of body's pH)
Which induction agent is contraindicated in patients with egg allergy?
Which intravenous anesthetic has minimal effects on cardiovascular system?
For which of the following drugs is the MOA clear: intravenous anesthetics, inhaled anesthetics, local anesthetics?
Rapid induction of anesthesia is achieved with an inhaled or intravenous anesthetic?
Maintenance of anesthesia occurs typically with an inhaled or intravenous anesthetic?
What hair color increases MAC?
What is the effect of inhaled anesthetics on minute ventilation?
For the inhaled anesthetics, speed of onset is determined by which property?
What gas is typically administered for analgesia?
Nitrous oxide (used a lot in labor)
What is the effect of inhaled agents on uterine tone?
decreases uterine tone
What does injection of intravenous opioids do to MAC?
decreases (i.e. when given opioids, you don't need as much anesthetic)
What do inhaled anesthetics do to the body's response to low blood oxygen?
Depresses this response
What do inhaled agents do to bronchomotor tone?
What do inhaled agents do to cerebral blood flow?
Increases it (this is why increased cranial pressure is a contraindication)
The inhaled agents are supplied from the manufacturer in what form?
What class of drugs are the inhaled anesthetics?
For the termination of a drug's effect, which is more important: redistribution or elimination?
What drug is contraindicated in patients with acute intermittent porphyria?
What does propofol do to cerebral blood flow?
What is the amount of IV anesthetic to prevent awareness?
We don't know
Which IV anesthetic can also be given IM
ketamine (we use it for patients that have no IV access)
In addition to potassium chloride and pancuronium (sp?), which IV anesthetic is used for lethal injection?
Thiopental causes hypotension by myocardial depression and...?
The term for the concept that the longer you infuse a drug, the longer it takes to eliminate?
The term for how drugs get to the effect site
The term for drug effect as a result of receptor binding
What is the most common cause of death among anesthesiologists under 35
Give an example where EMLA ointment would be used?
lumbar puncture in pediatric patients
Which local anesthetic is also used as an anti-arryhthmic?
Which of the following OTC drugs contains a local anesthetic: hydrocortisone; Tylenol PM; Bactim; Milk of magnesia
What agent is added to a local anesthetic to prolong the duration of blockade?
When a certain area receives anesthetic and this area does not respond to natural stimuli, this is also known as?
What property of a local anesthetic influences its duration?
lipid solubility (also determines its potency)
What protein channel do local anesthetics work on?
Which of the two stereoisomers of buvivicaine (sp?) is more cardiotoxic?
What type of local anesthetic is cocaine?
Inhaled anesthetics have been linked to the progression of which disease in adults?
The populational variance of inhaled anesthetics is large or small?
Induction of anesthesia occurs at the beginning, middle, or end of anesthesia?
The concentration of inhaled anesthetic necessary to prevent awareness is higher or lower than the amount needed to movement to pain?
Which inhaled anesthetic has the highest MAC?
Why is propofol used for sedation in the ICU?
it's quickly reversible
Which induction agent is also metabolized in the lungs and small intestine?
Which local anesthetic was first used for surgery?
Which local anesthetic is more rapidly metabolized when injected intravenously?
Which organ metabolizes amide local anesthetics?
Is there an antagonist to the inhaled anesthetics?
Which depends on drug metabolism: distribution half-life or elimination half-life
Propofol potentiates the effects of which neurotransmitter?
The primary termination of clinical effectiveness in local anesthetics is what?
Local anesthetics bind to which configurations of the sodium channel?
Open and inactive
The aromatic ring of the local anesthetic is hydrophilic or lipophilic?
Which local anesthetic has greater potential for allergic reaction?
Ester (one I in generic name)
Which intravenous anesthetic does not depress respiration?
Which will achieve a peak level first: inhaled or intravenous anesthetics?
Inhaled anesthetics has been linked to the progression of which disease in kids?
Developmental delay (learning disability)
In the resting state, the sodium channel is in what configuration?
What is the first symptom of toxicity from lidocaine?
Numbness of tongue
Which local anesthetic causes vasoconstriction?
Inhaled anesthetics with a low blood solubility will have a slow or fast onset of action?
Which anesthetic agent would be best for someone scheduled to go home?
When the entire body does not respond to noxious stimuli, that's also known as?
What is the breakdown product of ester local anesthetics?
Para-benzoic acid (PABA)
Which IV anesthetic increases intracranial pressure?
Which organ is the primary site of metabolism for IV anesthetics?
Do inhaled agents provide analgesia?
What do local anesthetics bind in the blood?
Albumin and alpha-1 glycoprotein
What is the effect of inhaled anesthetics on blood pressure?
Which IV anesthetic increases ICP and cerebral blood flow?
Local anesthetics are weak acids or weak bases?
The pKa of a local anesthetic determines what of the anesthetic?
The speed of onset
Name the two intermediate chains of local anesthetics
esters and amides
What is the term for the concentration of vapor that prevents movement and response to surgical incision in 50% of population?
MAC: minimum alveolar concentration
Which term describes an unaware patient who does not respond to pain?
Which of the following organs has the greatest uptake of local anesthetic following accidental IV injection: stomach, brain, muscle, skin?
Which IV anesthetic has analgesic properties?
What determines speed of onset of inhaled anesthetics, assuming same concentration and minute respiration?
What is the effect of inhaled anasthetics on temperature?
What property of a local anesthetic influences its potency?
Which IV anasthetic causes adrenocortical suppression?
What enzyme hydrolyzes ester local anasthetics?