CNS Tumor Features Flashcards Preview

Brain and Behavior II > CNS Tumor Features > Flashcards

Flashcards in CNS Tumor Features Deck (35):
1

Grade II glioma, no mitoses

Astrocytoma (diffuse)

2

Plump cells, glassy pink cytoplasm

Diffuse astrocytoma - gemicystic variant

3

Grade III glioma, mitoses

Anaplastic Astrocytoma

4

Multilayered glomeruloid tufts

Glioblastoma

5

Pseudopalisading necrosis

GBM. `Palisading` is when cells line up next to each other, like slats in a picket fence. These rapidly proliferating tumor cells (area outlined in green) appear to palisade around the central pale area, which represents necrotic tissue (region shaded in yellow).

6

Endothelial (microvascular) proliferation

GBM; several layers of endothelial cells filling lumen of vessel

7

Ki-67+, GFAP+, p53-, EGFR+

Glioblastoma

8

Rosenthal fibers

pilocytic astrocytoma

9

Chicken wire / fried egg

Oligodendroglioma

10

1p19q LOH

oligodendroglioma

11

EGFR amplification (chromosome 10)

Primary GBM

12

IDH1/2

Secondary GBM

13

Pseudorosettes

Ependymomas

14

Blue cell tumors

Medulloblastomas

15

Sugar icing appearance

Medulloblastomas

16

Whorls & cords of epithelial-like cells

Meningiomas

17

Pseudorosettes (ependymomas)

18

Pilocytic Astrocytoma

19

Pilocytic Astrocytoma

20

Eosinophilic Granular Bodies (PA)

21

Pseudopalisading Necrosis (GBM)

22

GBM Anaplasia

23

Microvascular Proliferation (GBM)

24

Oligodendroglioma (Fried Egg / Chicken Wire)

25

Medulloblastoma

26

Medulloblastoma

27

Meningioma (Whorls & Cords of epithelial-like cells)

28

Schwannoma 

29

What is the difference between a Schwannoma and a Neurofibroma?

Neurofibromas incorporate axons; Schwannomas push existing neural structures to the side.

30

Patients with NF2 are the ONLY type of patients to have what kind of bilateral tumor?

Bilateral acoustic/vestibular Schwannoma

31

Schwannoma v. Neurofibroma: NF1 or NF2?

NF1: Neurofibroma

NF2: Schwannoma

32

Meningioma Epidemiology

F > M

Up to 50% of patients with NF2

33

Tumors seen in patients with NF2?

Schwannomas, Meningiomas

34

Rosenthal Fibers (PA)

35

Neurofibroma (long segment)