CNS Tumor Features Flashcards Preview

Brain and Behavior II > CNS Tumor Features > Flashcards

Flashcards in CNS Tumor Features Deck (35):
1

Grade II glioma, no mitoses

Astrocytoma (diffuse)

2

Plump cells, glassy pink cytoplasm

Diffuse astrocytoma - gemicystic variant

3

Grade III glioma, mitoses

Anaplastic Astrocytoma

4

Multilayered glomeruloid tufts

Glioblastoma

5

Pseudopalisading necrosis

GBM. `Palisading` is when cells line up next to each other, like slats in a picket fence. These rapidly proliferating tumor cells (area outlined in green) appear to palisade around the central pale area, which represents necrotic tissue (region shaded in yellow).

6

Endothelial (microvascular) proliferation

GBM; several layers of endothelial cells filling lumen of vessel

7

Ki-67+, GFAP+, p53-, EGFR+

Glioblastoma

8

Rosenthal fibers

pilocytic astrocytoma

9

Chicken wire / fried egg

Oligodendroglioma

10

1p19q LOH

oligodendroglioma

11

EGFR amplification (chromosome 10)

Primary GBM

12

IDH1/2

Secondary GBM

13

Pseudorosettes

Ependymomas

14

Blue cell tumors

Medulloblastomas

15

Sugar icing appearance

Medulloblastomas

16

Whorls & cords of epithelial-like cells

Meningiomas

17

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Pseudorosettes (ependymomas)

18

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Pilocytic Astrocytoma

19

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Pilocytic Astrocytoma

20

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Eosinophilic Granular Bodies (PA)

21

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Pseudopalisading Necrosis (GBM)

22

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GBM Anaplasia

23

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Microvascular Proliferation (GBM)

24

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Oligodendroglioma (Fried Egg / Chicken Wire)

25

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Medulloblastoma

26

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Medulloblastoma

27

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Meningioma (Whorls & Cords of epithelial-like cells)

28

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Schwannoma 

29

What is the difference between a Schwannoma and a Neurofibroma?

Neurofibromas incorporate axons; Schwannomas push existing neural structures to the side.

30

Patients with NF2 are the ONLY type of patients to have what kind of bilateral tumor?

Bilateral acoustic/vestibular Schwannoma

31

Schwannoma v. Neurofibroma: NF1 or NF2?

NF1: Neurofibroma

NF2: Schwannoma

32

Meningioma Epidemiology

F > M

Up to 50% of patients with NF2

33

Tumors seen in patients with NF2?

Schwannomas, Meningiomas

34

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Rosenthal Fibers (PA)

35

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Neurofibroma (long segment)