CNS Tumor Features Flashcards by Mallory Irons

Q

Grade II glioma, no mitoses

A

Astrocytoma (diffuse)

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Plump cells, glassy pink cytoplasm

A

Diffuse astrocytoma - gemicystic variant

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Grade III glioma, mitoses

A

Anaplastic Astrocytoma

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Multilayered glomeruloid tufts

A

Glioblastoma

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Pseudopalisading necrosis

A

GBM. Palisading is when cells line up next to each other, like slats in a picket fence. These rapidly proliferating tumor cells (area outlined in green) appear to palisade around the central pale area, which represents necrotic tissue (region shaded in yellow).

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Endothelial (microvascular) proliferation

A

GBM; several layers of endothelial cells filling lumen of vessel

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Ki-67+, GFAP+, p53-, EGFR+

A

Glioblastoma

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Rosenthal fibers

A

pilocytic astrocytoma

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Chicken wire / fried egg

A

Oligodendroglioma

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

1p19q LOH

A

oligodendroglioma

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

EGFR amplification (chromosome 10)

A

Primary GBM

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

IDH1/2

A

Secondary GBM

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Pseudorosettes

A

Ependymomas

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Blue cell tumors

A

Medulloblastomas

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Sugar icing appearance

A

Medulloblastomas

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Whorls & cords of epithelial-like cells

Study These Flashcards

A

Meningiomas

Q

Study These Flashcards

A

Pseudorosettes (ependymomas)

Q

Study These Flashcards

A

Pilocytic Astrocytoma

Q

Study These Flashcards

A

Pilocytic Astrocytoma

Q

Study These Flashcards

A

Eosinophilic Granular Bodies (PA)

Q

Study These Flashcards

A

Pseudopalisading Necrosis (GBM)

Q

Study These Flashcards

A

GBM Anaplasia

Q

Study These Flashcards

A

Microvascular Proliferation (GBM)

Q

Study These Flashcards

A

Oligodendroglioma (Fried Egg / Chicken Wire)

Medulloblastoma

Medulloblastoma

Meningioma (Whorls & Cords of epithelial-like cells)

Schwannoma

What is the difference between a Schwannoma and a Neurofibroma?

Neurofibromas incorporate axons; Schwannomas push existing neural structures to the side.

Patients with NF2 are the ONLY type of patients to have what kind of bilateral tumor?

Bilateral acoustic/vestibular Schwannoma

Schwannoma v. Neurofibroma: NF1 or NF2?

NF1: Neurofibroma NF2: Schwannoma

Meningioma Epidemiology

F \> M Up to 50% of patients with NF2

Tumors seen in patients with NF2?

Schwannomas, Meningiomas

Rosenthal Fibers (PA)

Neurofibroma (long segment)