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Brain and Behavior II > Drugs > Flashcards

Flashcards in Drugs Deck (58):
1

MDMA (ecstasy)

reverses direction of SERT & blocks reuptake --> 5-HT extruded OUT of cell

2

Fenfluramine

VMAT blocker --> increases 5-HT in extracellular space

3

LSD

Serotonin receptor agonist

4

Antipsychotics

Serotonin receptor antagonist

5

Fluoxetine

SSRI (prozac)

6

Sertraline

SSRI (zoloft)

7

Paroxetine

SSRI (paxil)

8

Citalopram

SSRI (celexa)

9

Trazodone

Serotonin, NE receptor antagonist

10

Mirtazapine

Serotonin, NE, Dopamine receptor antagonist

11

Triptans

Serotonin receptor agonists (2C receptor) --> vasoconstriction

12

Carbidopa

Inhibits L-AAAD in the periphery

13

Disulfiram

Inhibits dopamine B-hydroxylase; inhibits acetaldehyde dehydrogenase (metabolism of acetaldehyde)

14

Reserpine

VMAT blocker --> increases 5-HT in extracellular space

15

Cocaine

Blocks reuptake of NE; Blocks dopamine transporter to inhibit reuptake

16

Imipramine

Blocks reuptake of NE, serotonin

17

Prednisone

synthetic corticosteroid

18

Chlorpromazine (Thorazine)

1st generation antipsychotic (low potency); block Dopamine at D2 receptor

19

Iproniazid

MAO inhibitor

20

Haloperidol

1st generation antipsychotic (high potency); block Dopamine at D2 receptor

21

Abilify (Aripiprazole)

2nd generation antipsychotic; block D2 and 5-HT receptors

22

Clozapine (Clozaril)

2nd generation antipsychotic; block D2 and 5-HT receptors

23

Lithium

Stabilize neuronal membrane by blocking voltage-gated Na+ channels

24

Benzodiazepines

Increase opening Cl- channel via GABA(A) receptor

25

Librium (Chlordiazepoxide)

Increase opening Cl- channel via GABA(A) receptor (low potency/long t1/2)

26

Aricept

AChE inhibitor

27

Namenda

NMDA receptor antagonist

28

Naltrexone

Opioid receptor antagonist

29

Acamprosate

Glutamatergic NMDA receptor antagonist; GABA-A agonist

30

Topiramate

AMPA (Glu) receptor antagonist; increases GABA-A activity

31

Morphine

Mu Opioid Receptor Agonist

32

Clonidine

a2-adrenergic receptor antagonist; inhibits NE release; treats HTN, panic attacks, RLS

33

Buprenorphine

Partial Mu Opioid receptor agonist

34

Methadone

Mu Opioid receptor agonist (full)

35

Naloxone

Opioid inverse agonist

36

Bupropion SR (Zyban)

Dopamine and norepipnephrine reuptake inhibitor and releaser

37

Varenicline

Partial NAchR agonist

38

Electroconvulsive Therapy

Brain defibrillator; acute Glu/GABA/monoaminergic function; alter neuronal connectivity

39

Transcranial Magnetic Stimulation

Induced electrical current in cortex

40

Magnetic Seizure Therapy

Focal TMS

41

Vagal Nerve Stimulation

stimulation of CNX and activation of monoaminergic nerves

42

Deep Brain Stimulation

Neural jamming via focal insertion of electrodes

43

Xanax (Alprazolam)

Potentiate activity at GABA-A receptor (high potency/short t1/2)

44

Lorazepam (Ativan)

Potentiate activity at GABA-A receptor (high potency/short t1/2); BYPASS LIVER

45

Klonopin (Clonazepam)

Potentiate activity at GABA-A receptor (high potency/long t1/2)

46

Oxazepam

Potentiate activity at GABA-A receptor low potency/short t1/2); BYPASS LIVER

47

Valium (Diazepam)

Potentiate activity at GABA-A receptor low potency/long t1/2)

48

Amphetamine (Adderall)

Binds to monoamine transporters and increases neuronal concentrations of dopamine

49

Methylphenidate (Ritalin)

NE / Dopamine reuptake inhibitor

50

Methamphetamine

Reverses flow of 5-HT/NE/D transporters (NT --> cytoplasm --> synapse)

51

Oxycodone

K-opioid agonist / M-opioid agonist (disputed)

52

Heroin

M-opioid agonist

53

Morphine

M-opioid agonist

54

Cocaine Vaccine

Cocaine molecule + cholera vaccine --> cocaine-specific antibody

55

Marijuana

CB1 receptor agonist

56

Nicotine

Nictonic acetylcholine receptor agonist --> increased dopamine in reward circuits

57

Dronabinol

Cannabinoid agonist

58

Nabilone

Cannabinoid agonist