Drugs Flashcards

(58 cards)

1
Q

MDMA (ecstasy)

A

reverses direction of SERT & blocks reuptake –> 5-HT extruded OUT of cell

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2
Q

Fenfluramine

A

VMAT blocker –> increases 5-HT in extracellular space

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3
Q

LSD

A

Serotonin receptor agonist

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4
Q

Antipsychotics

A

Serotonin receptor antagonist

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5
Q

Fluoxetine

A

SSRI (prozac)

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6
Q

Sertraline

A

SSRI (zoloft)

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7
Q

Paroxetine

A

SSRI (paxil)

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8
Q

Citalopram

A

SSRI (celexa)

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9
Q

Trazodone

A

Serotonin, NE receptor antagonist

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10
Q

Mirtazapine

A

Serotonin, NE, Dopamine receptor antagonist

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11
Q

Triptans

A

Serotonin receptor agonists (2C receptor) –> vasoconstriction

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12
Q

Carbidopa

A

Inhibits L-AAAD in the periphery

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13
Q

Disulfiram

A

Inhibits dopamine B-hydroxylase; inhibits acetaldehyde dehydrogenase (metabolism of acetaldehyde)

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14
Q

Reserpine

A

VMAT blocker –> increases 5-HT in extracellular space

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15
Q

Cocaine

A

Blocks reuptake of NE; Blocks dopamine transporter to inhibit reuptake

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16
Q

Imipramine

A

Blocks reuptake of NE, serotonin

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17
Q

Prednisone

A

synthetic corticosteroid

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18
Q

Chlorpromazine (Thorazine)

A

1st generation antipsychotic (low potency); block Dopamine at D2 receptor

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19
Q

Iproniazid

A

MAO inhibitor

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20
Q

Haloperidol

A

1st generation antipsychotic (high potency); block Dopamine at D2 receptor

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21
Q

Abilify (Aripiprazole)

A

2nd generation antipsychotic; block D2 and 5-HT receptors

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22
Q

Clozapine (Clozaril)

A

2nd generation antipsychotic; block D2 and 5-HT receptors

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23
Q

Lithium

A

Stabilize neuronal membrane by blocking voltage-gated Na+ channels

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24
Q

Benzodiazepines

A

Increase opening Cl- channel via GABA(A) receptor

25
Librium (Chlordiazepoxide)
Increase opening Cl- channel via GABA(A) receptor (low potency/long t1/2)
26
Aricept
AChE inhibitor
27
Namenda
NMDA receptor antagonist
28
Naltrexone
Opioid receptor antagonist
29
Acamprosate
Glutamatergic NMDA receptor antagonist; GABA-A agonist
30
Topiramate
AMPA (Glu) receptor antagonist; increases GABA-A activity
31
Morphine
Mu Opioid Receptor Agonist
32
Clonidine
a2-adrenergic receptor antagonist; inhibits NE release; treats HTN, panic attacks, RLS
33
Buprenorphine
Partial Mu Opioid receptor agonist
34
Methadone
Mu Opioid receptor agonist (full)
35
Naloxone
Opioid inverse agonist
36
Bupropion SR (Zyban)
Dopamine and norepipnephrine reuptake inhibitor and releaser
37
Varenicline
Partial NAchR agonist
38
Electroconvulsive Therapy
Brain defibrillator; acute Glu/GABA/monoaminergic function; alter neuronal connectivity
39
Transcranial Magnetic Stimulation
Induced electrical current in cortex
40
Magnetic Seizure Therapy
Focal TMS
41
Vagal Nerve Stimulation
stimulation of CNX and activation of monoaminergic nerves
42
Deep Brain Stimulation
Neural jamming via focal insertion of electrodes
43
Xanax (Alprazolam)
Potentiate activity at GABA-A receptor (high potency/short t1/2)
44
Lorazepam (Ativan)
Potentiate activity at GABA-A receptor (high potency/short t1/2); BYPASS LIVER
45
Klonopin (Clonazepam)
Potentiate activity at GABA-A receptor (high potency/long t1/2)
46
Oxazepam
Potentiate activity at GABA-A receptor low potency/short t1/2); BYPASS LIVER
47
Valium (Diazepam)
Potentiate activity at GABA-A receptor low potency/long t1/2)
48
Amphetamine (Adderall)
Binds to monoamine transporters and increases neuronal concentrations of dopamine
49
Methylphenidate (Ritalin)
NE / Dopamine reuptake inhibitor
50
Methamphetamine
Reverses flow of 5-HT/NE/D transporters (NT --> cytoplasm --> synapse)
51
Oxycodone
K-opioid agonist / M-opioid agonist (disputed)
52
Heroin
M-opioid agonist
53
Morphine
M-opioid agonist
54
Cocaine Vaccine
Cocaine molecule + cholera vaccine --> cocaine-specific antibody
55
Marijuana
CB1 receptor agonist
56
Nicotine
Nictonic acetylcholine receptor agonist --> increased dopamine in reward circuits
57
Dronabinol
Cannabinoid agonist
58
Nabilone
Cannabinoid agonist