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ATB > Anfenicóis > Flashcards

Anfenicóis Flashcards

1
Q

Anfenicois, exemplos

A

Cloranfenicol e Tianfenicol

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2
Q

Anfenicois

Mecanismo

A

Inibição da síntese proteica por meio da inibição da subunidade 50S. Bacteriostático geralmente.

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3
Q

Anfenicois competem com…

A

Clindamicina e Macrolídeos, pois têm o mesmo sítio.

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4
Q

Anfenicois

Penetração tecidual

A

Ótima penetração, incluindo SNC e BFP

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5
Q

Anfenicois

Segurança?

A

Muitos efeitos tóxicos.

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6
Q

Anfenicois

Efeitos adversos importantes

A

Anemia aplásica reversível/transitória x irreversível/fatal (rara)

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7
Q

Interação medicamentosa

A

Inibe o citocromo p450, prejudicando metabolismo da varfarina e de antiretrovirais.

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8
Q

Anfenicol no neonato

A

Síndrome do bebê cinzento (hipotonia, flacidez, cianose)

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9
Q

Anfenicois

Aplicação prática

A

Meningites por pneumococo, meningococo e hemófilos

Salmonella (febre tifoide) e Shigella (desinteria)

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ATB (12 decks)

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