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ANS Flashcards

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1
Q

Alpha 1 receptors actions

A

contraction :6
facilitate neuro m
increase total perip. R

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2
Q

Alpha 2 receptors actions

A

Dec. CNS
Dec symp.
Dec. renal

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3
Q

Presynatpic Beta actions

A

increase of noradernlaine

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4
Q

postsynaptic BETA 1 actions

A

Inc 4

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5
Q

Postsynaptic Beta 3 actions

A

increase lipolysis & thermogensis

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6
Q

postsyanptic beta 2 actions

A 
Generlized VD
Increase glucogenolysis
increase insulin relase 
increase of reuptake of K 
Skeletal muscle twitches
relaxation of uterus , GIT , UB
Bronchodiltation
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7
Q

where is alpha 1 receptors

A

mainly postsynaptic

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8
Q

absorption of adernaline

A 
not well by oral 
S.C
inhalation
glucoma 
caridac
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9
Q

Fate of adernaline

A

80 & metabilized
18& reuptake
2& uncharged

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10
Q

does adernaline pass BBB

A

no

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11
Q

Local actions of adernaline

A

Skin
MM
EYE *
Inhalataion

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12
Q

systemic actions of adernaline

A 
CNS * 
EYE
BV: 3
Heart:  3
BP 
Respiratory
GIT *
UB 
Uterus *
SK muscle : 3 *
Anti-allergic effect :2
endocrine * : 1
Metabolic : 4-3
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13
Q

Therupatic uses of adernaline

A 
Bronchal asthma
Acute hypoglycemia
Glucoma
Acute allergy *
Cardiac arrest 
hemosatatic *
with local anesthesia *
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14
Q

ADVERSE AFFECTS OF adernaline

A 
twitches
Heart problems
EYE : 2 *
CNS : 2 *
VC :3 *
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15
Q

what is drug that used at heart problems treatment of adernaline

A

B1 blocker : atenlol

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16
Q

what is drug that used for VC treatment of adernline

A

Alpha blocker : parazosin

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17
Q

Contradictions of adernaline

A 
Heart problems
Thyrotoxicosis
Around fingers & toes
hypertension
hemorrhage shock
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18
Q

what is cause of hemorrhage shock

A

renal V.C

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19
Q

Drugs interaction of adernaline

A

General anesthesia
Digitalis
Non-selective beta blockers :2

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20
Q

example for non-selective beta blockers

A

propanolol

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21
Q

what is source of adernaline

A

A cells of dura matter (80%) & some neurons at CNS

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22
Q

what happen if adernaline exposed to air or light or aqueous or alkaline medium

A

oxidized–>Adernochrome : very toxic & red

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23
Q

why at blood adernaline cant be oxidized

Study These Flashcards
A

reducing agents : glutathione & aschrobic acid

24
Q

what is source of nor-adernaline

Study These Flashcards
A

postganglionic sympathateic
Adernal medulla (20%)
phenocytochroma (90%)
CNS

25
How can noradernaline be adminstrated
I.V injection
26
Dynamics of noradernaline
``` CNS EYE BV CVS : 2 * GIT,UB UTERUS* METABOLSIM:2* ```
27
Therupatic uses of noradernlaine*
Acute hypotension | Local anesthesia
28
Adverse affects of noradernaline
``` Gnagrene Arryhtemia & badycardia cerebral hemorhage abortion sudden stop-->sever hypotension ```
29
what are contradictions of noradernaline
``` hypertension hemorrhage shock coronary heart disease around finger or toe general anesthesia extra vasation sudden stop ```
30
what are kinetcs of dropamine
similar to noradernaline
31
what are dynamics of dopamine
small dose : Stimulate D : V.D Moderate dose : stimulate D & B1 : VD+ inc. COP large dose : VC
32
therupatic uses of dopamine
Resistant heart failure | Shock : 3
33
adverse affects of dopamine
vomiting & nausea | hypertension & HEART problems
34
talk about kinetcs of epipherine
``` Absorbed orally , mm, paraentral Pass BBB not metabolized by MAO excreted uncharged acidifcation ```
35
talk about dynamics of epipherine
Dual or mixed idirect actions similar to adernaline but weaker , slower,tachypylaxis stimulate CNS
36
talk about amphetamine
more potent to CNS than ephedrine | addiction
37
what are actions of beta blockers
``` Heart * BV Anti-hypertensive* bronchi IOP metabolsim* ISA CNS Na channel block ```
38
what are uses of beta blockers
``` increase heart problems *2 Hypertension +alpha blockers in phenocytocroma glucoma headche anxiety & panic syndrome tremors ```
39
difference between two types of angina
angina of work : can be used with b blocker | variant (prinzmetal) angina : X be used with b blocker
40
what is drug responsible for badchardia , heart failure
virpamil
41
what are contradictions of beta blockers
``` Variant angina + decrease heart prbolems P.V.D hypotension alone with phenocytochroma brocnho asthma paractolo WITH insulin hyperkalemia inc. TAG or dec, HDL sediation sudden stop ```
42
Talk about non selective beta blocker
Heart Liver Limbs * Lung
43
Cardio selective beta 1 blocker
small dose with caution
44
example for Cardio selective beta 1 blocker
atenlol bisprolol metoprolol
45
example for alpha + beta blocker
carvilol + latenolol
46
What are central sympathoplegic drugs
alpha 2 agonists imidozlone I1 agnoists reserprin
47
example for alpha 2 agonists
alpha methyl dopa + colidene
48
example for imidozline I1 agonists
moxondine
49
who leads to more sedation
reserprin
50
2 enzymes of alpha methyl dopa
decarboxylase & beta hydroxylase
51
affects of alpha methyl dopa
``` Maintain RBF Inhibit catecholamines & serotonin Fluid , constipation , dry mouth CNS Allergy Hepatotoxcity hemaolytic anemia badicardia postural hypotension decrease renin ```
52
uses of alpha methyl dopa
hypertension : 3
53
can we use colidene at pregenency
no
54
what are disadvantages of colidene
large dose or iv : intial hypertension | sudden stop : sevre hypertension
55
what is treatment of sudden stop of colidene
alpha + beta blocker

Pharmacollogy (6 decks)

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