Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Pharmacollogy > Non-narcotic drugs > Flashcards

Non-narcotic drugs Flashcards

(54 cards)

Start Studying
1
Q

What are non narcotic anlgesics

A

CNS depressent with no narcosis
Dec. temp
Most

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

what is mechanism of non narcotic anlgesics

A

decrease COX

decrease synthesis of 3

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Talk about COX-1

A

PSYCHIC
STOMACH
KIDNEY

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

TALK ABOUT COX-2

A

inflamation : pathological

increase PG–> inflamation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

example of toxins of infections

A

IL-1

TNF

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

example for NSAID which is non selective COX inhibitors

A

Asprin ( salisclate)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

example for NSAID which is slective COX inhibtors

A

Celecoxib

rofecoxib

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Why dont we use saliscylic acid

A

very irritant

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

talk about saliscylic acid dervivtives for systemic & local use

A

S : A-N-SM-Diflunisal

L : SA-MS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Talk about pharmokinetcs of saliscylate

A

Absorption : Orall-stomach-intestine
Distribution : All-Tissues-albumin
Hepatic metabolism : mostly-little
Excretion : Mainly-Alklinzation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Talk about pharmokinetcs of paracetamol

A

Absorption : well
Hepatic metabolism : 95&-5%-large dose
Excretion : mostly metabolite-5% uncharged
Duration: 2-3

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

NABQ accumlation lead to

A

nephrotoxicity & hepatotoxicity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

duration of paracetamol

A

2-3

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

what are the elements that conjugate paracetoml & saliscylate

A

S : G-G

P : G-S-GT

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Talk about dynamics of salicylate of C.N.S

A

CNS :-
A: Central - peripheral : decrease PG: sensitivity
Anti-pyretic : dec. PG : heat loss-toxic dose :anti-gaba

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Talk about dynamics of salicylate of blood

A

Inflamation : decrease leucosytosis to normal
Hypothermia: large dose for long use
irreversible dec. platlet aggregation : small dose
heamolysis in favism

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Talk about dynamics of salicylate of uterus

A

dec.PG : relax uterus: tocolytic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Talk about dynamics of salicylate of uric acid

A

large dose : hyperuricema

small dose : urisucoric

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Talk about dynamics of salicylate of endocrine

A

increase hypothalamus
Increase adrenal medula
Increase displace of T3 & T4 : dec. T.S.H

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Talk about dynamics of salicylate of imune response

A

Increase cortisol : decrease Ag/At

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Talk about dynamics of salicylate of metabolism

A

Carb.:-
moderate dose: insulin like
large dose: hyperglycemia

Fat: lipolysis ketosis
Protein : catabolic : negative protein balance

B.M.R :increase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Talk about dynamics of salicylate of liver

Study These Flashcards
A

hydrocholric
increase adrenaline
hepatotoxic

23
Q

Talk about dynamics of salicylate of kidney

Study These Flashcards
A

decrease P.G & RENAL V.D : VC–> decrease R.M.F

large dose : neuropathy

24
Q

Talk about dynamics of salicylate of G.I.T

Study These Flashcards
A

Local : irritation

systmeic: Hyperacidity

25
Talk about dynamics of salicylate of respiratory & acid-base balance
Small : no large dose : increase R.C & respiratory alkalosis toxic dose : metabolic acidosis bronchial asthma : dec. COX & change LOX
26
Talk about dynamics of salicylate of C.V.S
therupatic : no toxic : V.D Patients with acute rheumatic
27
Talk about dynamics of salicylate of Anti-Iflammatory & Anti-Rheumatic
inhibit PG synthesis : dec. COX induced-Large dose | Dec. action kinins
28
what are mediators that affect by salicylate at C.N.S
Histamine Bradychinin 5-HT
29
what are mediators that affect by salicylate at anti-inflammatory
histamine kinins IL INF
30
Talk about paracetamol dynamics
dec. COX-3 at CNS : anti-pyretic & analgesic | no periphery action or anti-inflammatory action
31
what is the other name of paracetamol
Acetaminophen
32
Talk about therupatic uses of saliscylate
``` anti-pyretic analgesic : 3 rheumatic fever rheumatoid arthritis anti-platlet: prophylaxis agansit thrmobo prophylaxis aganist cancer , alzaheimr ```
33
Talk about therupatic uses of paracetamol
anti-pyretic analgesic to patients who cant tolerant: 6
34
how should i take paracetamol
250-500mg 3-4 times/day
35
talk about preparation of salicylate
Asprin : 2T-B-E-M Na : Enteric coated tablet Diflunsal: more 3 , no anti-pyretic-uricosuric-less 2
36
What are adverse affects of salicylate
``` acute toxicity Salicylsim GIT irritation Allergy Tetanogecity Idiosyncrasy neuropathy Reyes syndrome ```
37
Talk about contradictions of salicylate
``` Bronchal asthma pregenecy bleeding tendency allergy peptic ulcers idiosynercasy children Gout ```
38
examole of drug treat NSAID induced asthma
LOX inhibtors : zeiltunel | Cystenil LT-1 recpetorblockers : kast
39
example of drug treat NSAID induced ulcer
misoprostol
40
example for drugs that salicylate discplace and lead to what
oral anticogulants oral hypoglecima lead to toxcitity
41
what does salicylate antagonize
other urosceroic agents other anti inflammatory drugs anti hypertensive effect
42
which drug lead to increase metabolism of saliscyhlae
Phenobarbitone
43
which drugs lead to increase ulcergenic effect of salicylate
NSAID Alchol corticosteroids
44
which drug lead to increase & decrease excretion of salicylate
alkalinzers of urine as NaHCO3 : increase excretion | acidificers of urine : ammonium cholride : decrease
45
talk about side effects of paracetamol
allergy | toxic dose : dec. gluthionic SH: hepato-nephrotoxicity
46
what is managment of toxicity of paracetamol
oral methionen+ N-acetlsysteine
47
what are the rest of nsaid charcterized with
``` decrease COX1-2 at CNS & periphery gastic irritaion action displace other drugs anti-pyretic & analgesic anti-inflammotry action Contridcate with bronchal asthma & ulcer ```
48
what are uses of other NSAID
antipyretic analgesic anti-inflammatory: arthrits-mytosis-acute gout Colic: dysmenorrhea
49
what is small dose of salicylate
1g ( 3 tabletes)
50
what is large dose of salicylate
more than 5g ( more than 15 tabletes)
51
what is salicylate theruaptic index
high
52
what is toxic dose of salicylate
more than 200 mg
53
what are manifestations of acute toxicity of salicylate
``` hypotenstion hypoprothrembonia hyperacidity: heamdolysis hyperglycemia hyper reflexia hyperprepxia hyperventilation hyperthiridia convulsions , excitation till coma acid-base imbalance dehydration ```
54
what are managment of acute toxicity of salicylate
``` correct acid/base imbalance correct dehydration vit k + fresh blood anti-convulsions stomach wash by NaHCO3 heamdolysis increase urinary excretion ice bags ```

Pharmacollogy (6 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions