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Pharmacology > ANS 2 > Flashcards

ANS 2 Flashcards

1
Q

Has prominent CNS effects than atropine and has increased BBB permeation

A

Scopolamine

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2
Q

Antidote to Atropine Toxicity

A

Physostigmine

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3
Q

Causes CNS depression
(+) sedation

But at higher doses, can have excitation

A

Scopolamine ( S = Sedation)

Atropine = CNS excitation

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4
Q

Selective for M1, M4 receptors inhibiting gastric acid secretion

Also used for peptic ulcer disease

A

Pirenzipine and Telenzipine

Telenzipine more potent

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5
Q

Used to relieve symptoms of Parkinson’s Disease

A

Benztropine

(Park my Benz)

Also blocks Dopamine re-uptake and storage

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6
Q

Used to treat spams of the bladder

A

Oxybutynin

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7
Q

Tertiary Amine Muscarinic Receptor Blockers

A 
Telenzipine
Oxybutynin
Pirenzipine
Tropicamide
Atropine
Benztropine
Scopolamine

(TOP TABS)

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8
Q

Quaternary Amine efficient in Antisialogogue

A

Glycopyrrolate

M1 - stomach
M2 - no effect on eye, Inc HR
M3 - Antisialogogue

(Does not cross BBB - no effects on CNS)

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9
Q

Muscarinic blocker efficient in Increasing HR

A

Atropine

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10
Q

Muscarinic blocker efficient in Mydriasis and prevention of motion-induced nausea

A

Scopolamine

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11
Q

Blocks all types of muscarinic receptors and used for COPD and rhinorrhea

A

Tiotropium

Ipratropium Bromide

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12
Q

Quaternary Amines

A

Glycopyrrolate
Tiotropium
Ipratropium Bromide

(GIT)

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13
Q

Muscarinic Receptor Blockers

A

GIT TOP TABS

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14
Q

Adverse effects of Muscarinic Receptor Blockers

A 
Dry mouth
Blurred Vision
Hot, Flushed skin
Constipation
Difficulty Urination
Tachycardia
CNS Effects: Confusion, Sedation, delirium
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15
Q

Contraindications of Muscarinic Blockers

A

Open-angle Glaucoma
Prostatic Hypertrophy
Obstructive disease of the GIT and Urinary tract

POGI

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16
Q

Impairs ganglionic transmission by blocking the channel after it opens

A

Hexamethonium

17
Q

An anti-hypertensive agent

A

Hexamethonium
Trimethaphan

(Hexamethonium very potent)

(anTi-H)

18
Q

Impair ganglionic transmission by competing with
acetylcholine for ganglionic nicotinic receptor sites
(similar to the curare)

A

Trimethaphan

19
Q

(+) effectivity of low doses for blocking the central and peripheral effects of nicotine

A

Mecamylamine

addiction, mood disorders…

20
Q

Ganglionic Blockers

A

Hexamethonium
Trimethaphan
Mecamylamine

(Gang of MeTH)

21
Q

Initially depolarizes the membrane and will follow a neuromuscular blockade which is potentiated by Anti-AChE drugs

A

Succinylcholine

Relaxant, Hyperthermia, HyperKalemia, (+) histamine release

22
Q

Skeletal muscle relaxant for facilitation of Endotracheal intubation

A

Succinylcholine

23
Q

Can induce Malignant Hyperthermia in susceptible patients

A

Succinylcholine

24
Q

Effect of d-Tubocurarine in the Cardiovascular system

A

Hypotension

25
Q

___ is administration of d-Tubocurarine (3mg/70kg) prior to Succinylcholine to reduce fasciculation and muscle pains

A

Pre-curarization

26
Q

Independent of liver and kidney for termination of action

Ester Hydrolysis > Hoffman Elimination

A

Atracurium

27
Q

Metabolite of Atracurium and Cisatracurium

A

Laundanosine

Acryate fragment

28
Q

Blocks both muscarinic and nicotinic receptors

A

Pancuronium

29
Q

Used as Cardiac anesthesia

A

Pancuronium

Contraindicated for myocardial ischemia and tachycardia

30
Q

Metabolite is 3-OH and (-) histamine release

A

Pancuronium and Vecuronium

31
Q

Suitable for Ischemic heart disease

A

Vecuronium

32
Q

Has (-) histamine release and metabolite is 17-deacetylrocuronium

A

Rocuronium

33
Q

Replacement of Succinylcholine for rapid tracheal intubation

A

Rocuronium

34
Q

Name the Non-depolarizing neuromuscular blockers

A 
d-Tubocurarine
Vecuronium
Cisatracurium
Rocuronium
Atracurium
Pancuronium

(TV is CRAP)

35
Q

(+) histamine release

A

d-Tubocurarine

Atracurium

36
Q

Reverses Ocular effects of Atropine

A

Pilocarpine

Choline Esters

37
Q

Metabolism: Hoffman elimination > Ester Hydrolysis

A

Cisatracurium

Pharmacology (8 decks)

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