ANS 1

Question 1

Rate limiting step in Ach synthesis

Answer 1

Re-uptake of Choline

Question 2

Endogenous Choline Esters

Answer 2

ACh
Bethanechol
Carbechol
(ABChol)

Question 3

Has strong muscarinic activity

Answer 3

Bethanechol

Question 4

Used for atonic bladder

Answer 4

Bethanechol

Bladder = B

Question 5

Used for Glaucoma to decrease intraocular pressure

Answer 5

Carbachol

Question 6

An alkaloid used for Glaucoma but only has a muscarinic activity

Answer 6

Pilocarpine

(Extremely effective in opening the trabecular meshwork around
the Schlemm canal = Inc drainage)

Question 7

Antidote for pilocarpine poisoning

Answer 7

Atropine

Question 8

Reversible Cholinesterase inhibitor for diagnosis of Myasthenia Gravis

Answer 8

Edrophonium

Question 9

Test to differentiate Myasthenia Gravis vs Cholinergic Crisis?

Answer 9

Tensilon Test

Question 10

Reversible Cholinesterase inhibitor for treatment of overdose with anticholinergic drugs which can cross the BBB

Answer 10

Physostigimine

Question 11

Adverse effect of this Reversible Cholinesterase inhibitor is Cholinergic Crisis

Answer 11

Physostigimine

Question 12

Reversible Cholinesterase inhibitor which does not cross the BBB

Answer 12

Neostigimine

Question 13

Reversible Cholinesterase inhibitor for chronic management of Myasthenia Gravis

Answer 13

Pyridostigmine

Question 14

Reversible Cholinesterase inhibitor treatment for Alzheimers Disease

Answer 14

Donezepil
Tacrine

(Tacrine with Hepatotoxcity)

Question 15

Reversible Cholinesterase inhibitors

Answer 15

Physostigmine
Neostigmine
Pyridostigmine
Tacrine
Edrophonium
Donezepil

(PNP Takes Every Dollar)

Question 16

Atropine will reverse the effects of this irreversible cholinesterase inhibitor

Answer 16

Echothiopate Iodide

Question 17

Irreversible cholinesterase inhibitor used for open-angle glaucoma

Answer 17

Echothiophate iodide

Question 18

Used as an insecticide and treatment for pediculosis

Answer 18

Malathion

Question 19

Most volatile of the nerve gases

Answer 19

Sarin

Salarin

Question 20

Irreversible Cholinesterase inhibitors

Answer 20

Parathion
Nerve Gases
Malathion
Echothiopate Iodide
Diisoproply Fluorophosphate

(Puta Na MED)

Question 21

Determination of cholinesterase activity will confirm diagnosis of?

Answer 21

Acute Intoxication

Question 22

Most common cause of death of acute intoxication

Answer 22

Respiratory Failure

Question 23

Specific treatment for acute intoxication which antagonizes muscarinic activity

Answer 23

Atropine

Question 24

Reactivates inhibited AChE and antagonizes muscarinic and nicotinic actions at the NMJ of skeletal muscles BUT NOT CNS EFFECTS

Answer 24

Pralidoxine

Question 25

Nicotinic agonist which is selective for stimulation of autonomic ganglion cells and end-plates of skeletal muscle

Answer 25

Dimethylphenylpiperazinium (DMPP) also an hypertensive agent

Question 26

Peripheral nerve demyelination - progressive muscle weakness - sensory loss is what type of toxicity?

Answer 26

Chronic Toxicity

Question 27

- Potentiates inhibition of acetylcholine release | - ↑blocking effect on NMJ

Answer 27

Acetylcholinesterase + Aminoglycosides

Question 28

Reversal of neuromuscular blockade by non-depolarizing | muscle relaxant

Answer 28

Neostigmine + Non-depolarizing neuromuscular blocker

Question 29

a. ___ will contribute to the initial depolarization and will block pseudocholinesterase, which is needed to break down ACh b. ___ is a depolarizing neuromuscular blocker that first activates AChR causing initial fasciculations, then relaxation occurs.

Answer 29

a.Neostigmine + b. Succinylcholine