ANS 4

Question 1

Non selective alpha blocker which is non competitive and used prior to surgery for Pheochromocytoma

(tumor in adrenals)

Answer 1

Phenoxybenzamine

a1 > a2

Question 2

antagonism at a2 would result to?

Answer 2

enhance NE release

activates B1 = Inc HR, Inc Contraction

Question 3

A selective a1 antagonist

Answer 3

Prazosin

Question 4

Controlled by a1 in the genitourinary tract

Answer 4

Bladder neck
Urethra
Trigone

Question 5

Highly bound to a1-acid glycoprotein

Answer 5

Prazosin

Question 6

Structural analog of Prazosin with higher oral bioavailability

Answer 6

Terazosin

Question 7

a2 competitive antagonist

Answer 7

Yohimbine

Question 8

Action of Yohimbine

Answer 8

Inc Blood pressure

Due to enhanced release of NE

Question 9

Highly lipophilic B blocker

Answer 9

Propanolol

Question 10

B1 blocker which is metabolized by CYP2D6

Answer 10

Metoprolol

Question 11

Competitive antagonist to alpha and beta receptors

Answer 11

Labetalol

B 5-10x more > a

Question 12

Have the highest bioavailability with 90% and Longest half-life with 15hrs

Answer 12

Betaxolol

Question 13

B blockers approved for treatment of CHF

Answer 13

Metoprolol
Carvedilol
Bisoprolol

(MCdo Burger)

Question 14

Anti-Arrhythmic drugs with MSA

Answer 14

Metoprolol
Acebutolol
Propanolol

(MAP)

Question 15

Drugs for glaucoma which decreases the rate of synthesis of aqueous humor

Answer 15

Timolol

Question 16

B blockers with intrinsic sympathetic activity

Answer 16

Pindolol
Acebutolol
Carteolol
Labetalol

(CarLa Ace the Pin)

Question 17

A false neurotransmitter

Answer 17

Methyldopa

Question 18

Blocks VMAT which transports NE to vesicles and therefore accumulation of NE in cytoplasm will be degraded by MAO

Answer 18

Reserpine

Question 19

Inhibits release and depletes NE in sympathetic nerve endings

Answer 19

Guanethidine