ANS Flashcards Preview

Pharmacology :ANS-Adrenergics, Dyshem > ANS > Flashcards

Flashcards in ANS Deck (26)
Loading flashcards...
1

M1, 3, 5 : Result of ligand Binding

Gq + PLC

Formation of IP3( increaes intracellular calcium) and DAG (increases PKC)

2

M2,4: Result of Ligand Binding

Gi

Opening of Potassium channels and inhibition of adenylyl cyclase

3

M1 location

CNS NEURONS, sympathetic postganglionic neurons, some presynaptic sites;

Gastric parietal cells

4

M2 receptor locations

myocardium, smooth muschle, some presynaptic sites; CNS neurons

5

M3 receptor sites

Exocrine glands, vessels (sm. muscle and endothelium); CNS neurons

Pupillary sphincter muscle contraction (miosis) and ciliary contraction (accomodation)

6

M4 receptor sites

CNS neurons; possibly vagal nerve endings

7

M5 receptor locations

Vascular endothelium, especially cerebral vessels; CNS neurons

8

Nn locations

Autonomic System

Postganglionic neurons, some presynaptic cholinergic terminals

Adrenal gland (Chromaffin cell)

9

Nm locations

Somatic System

skeletal muscle neuromuscular end plates

10

Alpha receptors (1&2) locations

Vascular smooth muscle, presynaptic nerve terminals and platelets and in the brain

11

Beta receptor locations (1-3)

most types of smooth muscle, cardiac muscle, some presynaptic nerve terminals and in the brain

12

alpha 1 Receptor ligand binding effect

Gq activates PLC leading to increased DAG and IP3/Ca

13

alpha2 Receptor ligand binding effect

Gi inhibits AC leading to decreased cAMP

Gi activates K+ channel leading to hyperpolarization

14

Beta 1-3 receptor ligand binding effect

Gs activates AC and increases cAMP. Beta 2 activates Gi under some conditions

15

alpha 1 location

Postsynaptic effector cells, especially smooth muscles

Effector Organs: Arterioles in skin, mucosa, viscera, kidney (Resistance Vessels)
Veins, Uterus and Spleen

16

alpha 2 location

Presynaptic Adrenergic Nerve Terminals (endings), platelets, lipocytes, smooth muscle

Postsynaptic in CNS

17

beta 1 location

postsynaptic effector cells, especially Heart, lipocytes, Brain, Kidney
Presynaptic aderenergic cholineergic nerve terminals
Juxtaglomreular apparaguts of renal tubules
Ciliary body epithelium

18

Beta 2 location

postsynaptic effector cells, esp. smooth muscle and cardiac muscle

Prominent Effector Organs: arterioles (& arteries in skeletal muscle, coronary)
Bronchial Muscle
Pregnant Uterus

19

beta 3 location

postsynaptic effector cells, esp. Adipoe tissue: lipocytes, heart

20

D1 location

Renal, mesenteric, and cerebral arterioles

21

alpha 1 selective agonist and antagonist

Agonist: Phenylephrine
Antagonist: Prazosin

22

Alpha 2 Selective Agonist and Antagonist

Agonist: Clonidine
Antagonist: Yohimbine

23

D1 Selective Agonist

Fenoldopam

24

Beta 1 selective Agonist and Antagonist

Agonist: Dobutamine
Antagonist: Atenolol

25

Beta 2 selective agonist and antagonist

Agonist: Albuterol
Antagonist: Butoxamine

26

Nonselective beta 1 and beta 2 agoonists and antaganist

Agonist: Isoproterenol
Antagonist: Propranolol