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Pharmacology :ANS-Adrenergics, Dyshem > ANS > Flashcards

Flashcards in ANS Deck (26)
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1
Q

M1, 3, 5 : Result of ligand Binding

A

Gq + PLC

Formation of IP3( increaes intracellular calcium) and DAG (increases PKC)

2
Q

M2,4: Result of Ligand Binding

A

Gi

Opening of Potassium channels and inhibition of adenylyl cyclase

3
Q

M1 location

A

CNS NEURONS, sympathetic postganglionic neurons, some presynaptic sites;

Gastric parietal cells

4
Q

M2 receptor locations

A

myocardium, smooth muschle, some presynaptic sites; CNS neurons

5
Q

M3 receptor sites

A

Exocrine glands, vessels (sm. muscle and endothelium); CNS neurons

Pupillary sphincter muscle contraction (miosis) and ciliary contraction (accomodation)

6
Q

M4 receptor sites

A

CNS neurons; possibly vagal nerve endings

7
Q

M5 receptor locations

A

Vascular endothelium, especially cerebral vessels; CNS neurons

8
Q

Nn locations

A

Autonomic System

Postganglionic neurons, some presynaptic cholinergic terminals

Adrenal gland (Chromaffin cell)

9
Q

Nm locations

A

Somatic System

skeletal muscle neuromuscular end plates

10
Q

Alpha receptors (1&2) locations

A

Vascular smooth muscle, presynaptic nerve terminals and platelets and in the brain

11
Q

Beta receptor locations (1-3)

A

most types of smooth muscle, cardiac muscle, some presynaptic nerve terminals and in the brain

12
Q

alpha 1 Receptor ligand binding effect

A

Gq activates PLC leading to increased DAG and IP3/Ca

13
Q

alpha2 Receptor ligand binding effect

A

Gi inhibits AC leading to decreased cAMP

Gi activates K+ channel leading to hyperpolarization

14
Q

Beta 1-3 receptor ligand binding effect

A

Gs activates AC and increases cAMP. Beta 2 activates Gi under some conditions

15
Q

alpha 1 location

A

Postsynaptic effector cells, especially smooth muscles

Effector Organs: Arterioles in skin, mucosa, viscera, kidney (Resistance Vessels)
Veins, Uterus and Spleen

16
Q

alpha 2 location

A

Presynaptic Adrenergic Nerve Terminals (endings), platelets, lipocytes, smooth muscle

Postsynaptic in CNS

17
Q

beta 1 location

A

postsynaptic effector cells, especially Heart, lipocytes, Brain, Kidney
Presynaptic aderenergic cholineergic nerve terminals
Juxtaglomreular apparaguts of renal tubules
Ciliary body epithelium

18
Q

Beta 2 location

A

postsynaptic effector cells, esp. smooth muscle and cardiac muscle

Prominent Effector Organs: arterioles (& arteries in skeletal muscle, coronary)
Bronchial Muscle
Pregnant Uterus

19
Q

beta 3 location

A

postsynaptic effector cells, esp. Adipoe tissue: lipocytes, heart

20
Q

D1 location

A

Renal, mesenteric, and cerebral arterioles

21
Q

alpha 1 selective agonist and antagonist

A

Agonist: Phenylephrine
Antagonist: Prazosin

22
Q

Alpha 2 Selective Agonist and Antagonist

A

Agonist: Clonidine
Antagonist: Yohimbine

23
Q

D1 Selective Agonist

A

Fenoldopam

24
Q

Beta 1 selective Agonist and Antagonist

A

Agonist: Dobutamine
Antagonist: Atenolol

25
Q

Beta 2 selective agonist and antagonist

A

Agonist: Albuterol
Antagonist: Butoxamine

26
Q

Nonselective beta 1 and beta 2 agoonists and antaganist

A

Agonist: Isoproterenol
Antagonist: Propranolol