Flashcards in Dyshemoglobinemias Deck (9)
Mild CO Acute Clinical Effects
HA, N/V, dizziness
Moderate CO Acute Ciinical Effects
Chest Pain, Blurred Vision, Tachycardia, Tachypnea, Dyspnea upon exertion, Cognitive Deficits, Myonecrosis, Ataxia
Severe CO Acute Clinical Effects
CO Late/Chronic Efects
Dementia, Psychosis, Amnesia
Parkinsonism, Paralysis Chorea, Cortical Blindness, Apraxia, Anosias, Peripheral Neuropathy, Incontinence
When does "late /Chronic effects" from CO poisoning occur?
After lucent period which lasts areound 2-40 days
What are the two reperfusion injury theories in regards to CO Late Effects?
1. WBS's are attracted and adhere to the microvasculature of the brain
2. WBC's release proteases that convert xanthine dehydrogenase to xanthene oxidase, facilitating free radical formation and leads to delayed lipid peroxidations
How do you evaluate for CO poisoning?
Check for end organ manifestations of toxicity and measure the lebel using arterial blood gas co-oximeter. Pulse oximetry and calculation form arterial blood gas will be falsely normal.
How does ABC's and oxygen and hyperbaric oxygen sork to trat CO toxxxicitiy?
ABC's shorten CO t1/2 to 2-7 hr and HBO shortens t1/2 (4-86 mins) increased O2