Dyshemoglobinemias Flashcards Preview

Pharmacology :ANS-Adrenergics, Dyshem > Dyshemoglobinemias > Flashcards

Flashcards in Dyshemoglobinemias Deck (9)
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1

Mild CO Acute Clinical Effects

HA, N/V, dizziness

2

Moderate CO Acute Ciinical Effects

Chest Pain, Blurred Vision, Tachycardia, Tachypnea, Dyspnea upon exertion, Cognitive Deficits, Myonecrosis, Ataxia

3

Severe CO Acute Clinical Effects

Seizures
Coma
Dysrhythmias, Hypotension
Mi/Ischemia
Skin Bullae

4

CO Late/Chronic Efects

Cognitive Dysfunction
Dementia, Psychosis, Amnesia
Parkinsonism, Paralysis Chorea, Cortical Blindness, Apraxia, Anosias, Peripheral Neuropathy, Incontinence

5

When does "late /Chronic effects" from CO poisoning occur?

After lucent period which lasts areound 2-40 days

6

What are the two reperfusion injury theories in regards to CO Late Effects?

1. WBS's are attracted and adhere to the microvasculature of the brain
2. WBC's release proteases that convert xanthine dehydrogenase to xanthene oxidase, facilitating free radical formation and leads to delayed lipid peroxidations

7

How do you evaluate for CO poisoning?

Check for end organ manifestations of toxicity and measure the lebel using arterial blood gas co-oximeter. Pulse oximetry and calculation form arterial blood gas will be falsely normal.

8

How does ABC's and oxygen and hyperbaric oxygen sork to trat CO toxxxicitiy?

ABC's shorten CO t1/2 to 2-7 hr and HBO shortens t1/2 (4-86 mins) increased O2

9

What are some indications for HBO?

Presentation of Syncope, Comas, Seisures (GCS 4-15)
CO level greater than 25%